Morphine-activated opioid receptors elude desensitization by β-arrestin

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

1996 • 1,652 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Morphine Activates Opioid Receptors without Causing Their Rapid Internalization

1996 • 536 citations

Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia

1997 • 511 citations

Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness

1998 • 501 citations

Effects of mutant rat dynamin on endocytosis

1993 • 453 citations

A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation

1997 • 420 citations

Arrestin Interactions with G Protein-coupled Receptors

1995 • 385 citations

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

1996 • 327 citations

mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain.

1998 • 323 citations

Phosphorylation and Agonist‐Specific Intracellular Trafficking of an Epitope‐Tagged μ‐Opioid Receptor Expressed in HEK 293 Cells

1995 • 291 citations

μ-Opioid Receptor Internalization: Opiate Drugs Have Differential Effects on a Conserved Endocytic MechanismIn Vitroand in the Mammalian Brain

1998 • 265 citations

Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.

1995 • 222 citations

μ Opioid Receptor Phosphorylation, Desensitization, and Ligand Efficacy

1997 • 218 citations

The Effect of Intrinsic Efficacy on Opioid Tolerance

1995 • 211 citations

Visual Arrestin Binding to Rhodopsin

1995 • 157 citations

δ and κ Opioid Receptors Are Differentially Regulated by Dynamin-dependent Endocytosis When Activated by the Same Alkaloid Agonist

1997 • 139 citations

Down-regulation of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Chloroquine promotes accumulation of tritiated enkephalin in the lysosomes.

1984 • 139 citations

Thr353, Located within the COOH-terminal Tail of the ´ Opiate Receptor, Is Involved in Receptor Down-regulation

1996 • 105 citations

Decrease in δ-opioid receptor density in rat brain after chronic [d-Ala2,d-Leu5]enkephalin treatment

1988 • 103 citations

Opioid Receptors and the Regulation of Ion Conductances

1995 • 54 citations

Agonist-induced state of the delta-opioid receptor that discriminates between opioid peptides and opiate alkaloids.

1993 • 42 citations

Characterization and down-regulation of opiate receptors in aggregating fetal rat brain cells

1984 • 31 citations

Intracellular trafficking of epitope-tagged opioid receptors: Different effects of morphine and enkephalin

1994 • 16 citations

Selectivity in the control of opiate receptor density in the animal and in cultured fetal brain cells

1984 • 8 citations