Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Fluorometric assay of proteins in the nanogram range

1973 • 1,640 citations

A Micro Biuret Method for Protein Determination Determination of Total Protein in Cerebrospinal Fluid

1953 • 1,089 citations

Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase

1961 • 1,041 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme

1969 • 898 citations

Membrane Receptors

1974 • 636 citations

Membrane receptors for hormones and neurotransmitters.

1976 • 573 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 487 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 473 citations

LYSOSOMES OF THE ARTERIAL WALL

1972 • 410 citations

Enzyme Topology of Intracellular Membranes

1977 • 390 citations

Tissue fractionation studies. 15. Intracellular distribution and properties of β-N-acetylglucos-aminidase and β-galactosidase in rat liver

1960 • 379 citations

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

1982 • 336 citations

ANALYTICAL STUDY OF MICROSOMES AND ISOLATED SUBCELLULAR MEMBRANES FROM RAT LIVER

1974 • 252 citations

Modulation of Adenylate Cyclase Activity in Liver and Fat Cell Membranes by Insulin

1972 • 243 citations

Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.

1982 • 221 citations

Hormone-sensitive adenylyl cyclases useful models for studying hormone receptor functions in cell-free systems

1973 • 219 citations

A partial view of the mechanism of insulin action

1981 • 215 citations

Stimulation of a low Km phosphodiesterase from liver by insulin and glucagon.

1978 • 208 citations

THE ROLE OF CYCLIC AMP IN THE INTERACTION OF GLUCAGON AND INSULIN IN THE CONTROL OF LIVER METABOLISM*

1971 • 205 citations

Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats

1975 • 202 citations

The membrane systems of the mitochondrion

1966 • 185 citations

The Regulation of Gluconeogenesis in Isolated Rat Liver Cells by Glucagon, Insulin, Dibutyryl Cyclic Adenosine Monophosphate, and Fatty Acids

1972 • 180 citations

A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

1980 • 174 citations

The properties and extracellular location of 5′-nucleotidase of the rat fat-cell plasma membrane

1975 • 170 citations

Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats☆

1974 • 163 citations

The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it

1976 • 158 citations

Subcellular distribution and movement of 5'-nucleotidase in rat cells

1980 • 156 citations

Insulin triggers cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase

1980 • 149 citations

Binding of 125I-labeled glucagon and glucagon-stimulated accumulation of adenosine 3‘:5‘-monophosphate in isolated intact rat hepatocytes. Evidence for receptor heterogeneity.

1978 • 127 citations

Insulin action on the adenyl cyclase system: Antagonism to activation by lipolytic hormones

1972 • 109 citations

Studies on alpha-adrenergic activation of hepatic glucose output. Insulin inhibition of alpha-adrenergic and glucagon actions in normal and calcium-depleted hepatocytes.

1979 • 109 citations

Changes in the form of Arrhenius plots of the activity of glucagon-stimulated adenylate cyclase and other hamster liver plasma-membrane enzymes occurring on hibernation

1978 • 106 citations

Internalization of insulin into rat liver Golgi elements. Evidence for vesicle heterogeneity and the path of intracellular processing.

1982 • 98 citations

Distribution of liver plasma membrane 5′ nucleotidase as indicated by its reaction with anti-plasma membrane serum

1974 • 89 citations

Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes

1983 • 81 citations

Effect of insulin and growth hormone on rat liver cyclic nucleotide phosphodiesterase

1973 • 76 citations

Use of isolated liver cells and kidney tubules in metabolic studies

1977 • 71 citations

Intracellular hormone receptors: evidence for insulin and lactogen receptors in a unique vesicle sedimenting in lysosome fractions of rat liver.

1981 • 70 citations

Characterization of the phosphorylated form of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes

1981 • 61 citations

Guanosine 5′-triphosphate and guanosine 5′-[βγ-imido]triphosphate effect a collision coupling mechanism between the glucagon receptor and catalytic unit of adenylate cyclase

1980 • 57 citations

Coupling of glucagon receptor to adenylyl cyclase. Requirement of a receptor-related guanyl nucleotide binding site for coupling of receptor to the enzyme.

1979 • 57 citations

Functional exchange of components between light-activated photoreceptor phosphodiesterase and hormone-activated adenylate cyclase systems.

1982 • 57 citations

Differential effects of tryptophan on glucose synthesis in rats and guinea pigs

1978 • 54 citations

The demonstration of a specific 5′-nucleotidase activity in rat tissues

1975 • 51 citations

Receptors and Hormone Action

1978 • 49 citations

Rapid fractionation of cell suspensions with the use of brominated hydrocarbons

1980 • 48 citations

Isolation of peroxisomes from rat liver using sucrose and Percoll gradients

1981 • 47 citations

Light- and GTP-activated photoreceptor phosphodiesterase: regulation by a light-activated GTPase and identification of rhodopsin as the phosphodiesterase binding site.

1978 • 45 citations

Cholera toxin modifies diverse GTP-modulated regulatory proteins

1981 • 42 citations

Cholera toxin mediated activation of adenylate cyclase in intact rat hepatocytes

1979 • 41 citations

Quantitative estimation of 3′5′ cyclic AMP phosphodiesterase using anion exchange resin in a batch process

1976 • 41 citations

Guanine nucleotides can activate the insulin‐stimulated phosphodiesterase in liver plasma membranes

1983 • 40 citations

Insulin controls the cyclic AMP‐dependent phosphorylation of integral and peripheral proteins associated with the rat liver plasma membrane

1980 • 28 citations

Submitochondrial localization and asymmetric disposition of two peripheral cyclic nucleotide phosphodiesterases

1982 • 26 citations

Inhibition of the glucagon stimulated adenylate cyclase activity by insulin

1978 • 18 citations

Heterogeneity of cyclic nucleotide phosphodiesterases in liver endoplasmic reticulum

1983 • 11 citations

Proteolytic activation and solubilization of endoplasmic-reticulum cyclic AMP phosphodiesterase activity

1983 • 8 citations

A batch procedure for the assay of cyclic nucleotide phosphodiesterase

1978 • 5 citations