Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme

1969 • 898 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 487 citations

Reconstitution of a Calcium Pump Using Defined Membrane Components

1974 • 420 citations

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.

1980 • 342 citations

Hormonal control of cyclic 3':5'-AMP levels and gluconeogenesis in isolated hepatocytes from fed rats

1975 • 202 citations

The Regulation of Gluconeogenesis in Isolated Rat Liver Cells by Glucagon, Insulin, Dibutyryl Cyclic Adenosine Monophosphate, and Fatty Acids

1972 • 180 citations

The hepatic adenylate cyclase system. I. Evidence for transition states and structural requirements for guanine nucloetide activiation

1975 • 171 citations

The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it

1976 • 158 citations

Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes

1983 • 156 citations

Insulin-induced loss of the insulin receptor in IM-9 lymphocytes. A biological process mediated through the insulin receptor.

1980 • 149 citations

Binding of 125I-labeled glucagon and glucagon-stimulated accumulation of adenosine 3‘:5‘-monophosphate in isolated intact rat hepatocytes. Evidence for receptor heterogeneity.

1978 • 127 citations

Exchange of partners in glucagon receptor-adenylate cyclase complexes. Physical evidence for the independent, mobile receptor model

1977 • 113 citations

Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.

1981 • 96 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Altered guanine nucleotide hydrolysis as basis for increased adenylate cyclase activity after cholera toxin treatment.

1977 • 92 citations

Effects of GTP on binding of (3H) glucagon to receptors in rat hepatic plasma membranes.

1977 • 91 citations

Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component.

1981 • 75 citations

Hysteretic activation of adenylyl cyclases. I. Effect of Mg ion on the rate of activation by guanine nucleotides and fluoride.

1981 • 74 citations

Mechanism of desensitization of adenylate cyclase in lutropin. GTP-dependent uncoupling of the receptor.

1980 • 74 citations

Evidence in intact cells for an involvement of GTP in the activation of adenylate cyclase.

1979 • 62 citations

Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets

1981 • 62 citations

Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes.

1980 • 60 citations

Guanosine 5′-triphosphate and guanosine 5′-[βγ-imido]triphosphate effect a collision coupling mechanism between the glucagon receptor and catalytic unit of adenylate cyclase

1980 • 57 citations

Differential effects of tryptophan on glucose synthesis in rats and guinea pigs

1978 • 54 citations

Isoproterenol-induced desensitization of adenylate cyclase responsiveness in a cell-free system.

1979 • 52 citations

Transient complexes. A structural model for the activation of adenylate cyclase by hormone receptors (guanine nucleotides/irradiation inactivation)

1979 • 44 citations

Cholera toxin mediated activation of adenylate cyclase in intact rat hepatocytes

1979 • 41 citations

Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase.

1979 • 33 citations

Direct Evidence of a Glucagon-Dependent Regulation of the Concentration of Glucagon Receptors in the Liver

1982 • 29 citations

Mobile receptor and collision coupling mechanisms for the activation of adenylate cyclase by glucagon.

1981 • 18 citations

Resensitization of lutropin-desensitized tumour Leydig-cell adenylate cyclase with human erythrocyte membranes

1982 • 15 citations

Energy-dependent activation and magnesium-dependent in activation of hepatocyte hormone-sensitive phosphodiesterase

1981 • 6 citations