Toll-Like Receptors and RNA Helicases: Two Parallel Ways to Trigger Antiviral Responses

Innate Immune Recognition

2002 • 8,157 citations

Toll-like receptor signalling

2004 • 7,983 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

2004 • 3,745 citations

Virus interference. I. The interferon

1957 • 3,331 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

2005 • 3,059 citations

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

2005 • 2,741 citations

IKKε and TBK1 are essential components of the IRF3 signaling pathway

2003 • 2,536 citations

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

2005 • 2,449 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

2005 • 2,312 citations

Complete Replication of Hepatitis C Virus in Cell Culture

2005 • 2,239 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

2005 • 1,761 citations

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

2004 • 1,759 citations

Robust hepatitis C virus infectionin vitro

2005 • 1,691 citations

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

2003 • 1,625 citations

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

2005 • 1,602 citations

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

2000 • 1,374 citations

Viruses and interferon: a fight for supremacy

2002 • 1,335 citations

Cell Type-Specific Involvement of RIG-I in Antiviral Response

2005 • 1,311 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

2002 • 1,228 citations

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

2003 • 1,226 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

Highly Permissive Cell Lines for Subgenomic and Genomic Hepatitis C Virus RNA Replication

2002 • 1,181 citations

TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY

2004 • 1,157 citations

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

2003 • 1,137 citations

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

2004 • 1,109 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

2005 • 1,062 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

2004 • 994 citations

Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response

2006 • 983 citations

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN -β promoter

2004 • 947 citations

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

2005 • 915 citations

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

2003 • 907 citations

Toll-like receptor 3 promotes cross-priming to virus-infected cells

2005 • 902 citations

Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I

2005 • 882 citations

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

2005 • 847 citations

RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation

2004 • 821 citations

Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease

2003 • 799 citations

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

2005 • 799 citations

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

2005 • 755 citations

Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling

2003 • 692 citations

The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes

2004 • 674 citations

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

2005 • 649 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 • 640 citations

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

2002 • 619 citations

The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I

2005 • 602 citations

NF-kappa B activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

1999 • 554 citations

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1997 • 552 citations

Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

2005 • 547 citations

Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4

2004 • 526 citations

The Toll–IL-1 receptor adaptor family grows to five members

2003 • 491 citations

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

2005 • 468 citations

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling

2000 • 456 citations

TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β

2003 • 399 citations

Signal Integration via PKR

2001 • 395 citations

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

2000 • 365 citations

NAK is an IκB kinase-activating kinase

2000 • 365 citations

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases

1999 • 362 citations

Structure and Function of the Interferon- Enhanceosome

1998 • 354 citations

Does Toll-like receptor 3 play a biological role in virus infections?

2004 • 354 citations

Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence

2005 • 348 citations

The dsRNA binding protein family: critical roles, diverse cellular functions

2003 • 346 citations

Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3

2002 • 336 citations

IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex

2000 • 323 citations

Rip1 Mediates the Trif-dependent Toll-like Receptor 3- and 4-induced NF-κB Activation but Does Not Contribute to Interferon Regulatory Factor 3 Activation

2005 • 322 citations

Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR

2003 • 300 citations

Cutting Edge: TNFR-Associated Factor (TRAF) 6 Is Essential for MyD88-Dependent Pathway but Not Toll/IL-1 Receptor Domain-Containing Adaptor-Inducing IFN-β (TRIF)-Dependent Pathway in TLR Signaling

2004 • 294 citations

Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

2005 • 268 citations

Mechanisms of the TRIF-induced Interferon-stimulated Response Element and NF-κB Activation and Apoptosis Pathways

2004 • 247 citations

IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein

2001 • 223 citations

TLR3 in antiviral immunity: key player or bystander?

2005 • 220 citations

Replicative form of Encephalomyocarditis Virus Ribonucleic Acid

1963 • 219 citations

Inverse Interference: How Viruses Fight the Interferon System

2004 • 213 citations

Negative Regulation of the Retinoic Acid-inducible Gene I-induced Antiviral State by the Ubiquitin-editing Protein A20

2005 • 212 citations

Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner

2005 • 187 citations

Inhibition of RIG-I-Dependent Signaling to the Interferon Pathway during Hepatitis C Virus Expression and Restoration of Signaling by IKKε

2005 • 169 citations

SIKE is an IKKε/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways

2005 • 152 citations

The modular nature of apoptotic signaling proteins

1999 • 150 citations

Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation

2002 • 137 citations

Virus-Specific Double-Stranded RNA in Poliovirus-Infected Cells

1964 • 134 citations

Cutting Edge: NF-κB-Activating Kinase-Associated Protein 1 Participates in TLR3/Toll-IL-1 Homology Domain-Containing Adapter Molecule-1-Mediated IFN Regulatory Factor 3 Activation

2005 • 132 citations

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-κB and ISRE and IFN-β promoter

2004 • 120 citations

Transcriptional Activation of Alpha/Beta Interferon Genes: Interference by Nonsegmented Negative-Strand RNA Viruses

2005 • 118 citations

Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4

2005 • 115 citations

TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF

2005 • 94 citations

An RNA helicase, RHIV -1, induced by porcine reproductive and respiratory syndrome virus (PRRSV) is mapped on porcine chromosome 10q13

2000 • 62 citations

TNF receptor‐associated factor‐1 (TRAF1) negatively regulates Toll/IL‐1 receptor domain‐containing adaptor inducing IFN‐β (TRIF)‐mediated signaling

2005 • 56 citations

PKR Protection Against Intranasal Vesicular Stomatitis Virus Infection Is Mouse Strain Dependent

2002 • 52 citations

PIASy represses TRIF‐induced ISRE and NF‐κB activation but not apoptosis

2004 • 42 citations

Negative regulation of the RIG-I induced antiviral state by the ubiquitin editing protein A20

2006 • 1 citations