Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

1994 • 1,752 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus

2001 • 1,245 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

2002 • 1,090 citations

Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

2004 • 972 citations

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

2002 • 897 citations

Antibodies to DNA

1998 • 672 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase

2002 • 627 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus

2002 • 549 citations

Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status

1999 • 484 citations

Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand

1998 • 377 citations

Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function.

1998 • 353 citations

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

1993 • 350 citations

Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus

2003 • 341 citations

Apoptotic Cells with Oxidation-specific Epitopes Are Immunogenic and Proinflammatory

2004 • 336 citations

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

1998 • 323 citations

Cutting Edge: Bystander Apoptosis Triggers Dendritic Cell Maturation and Antigen-Presenting Function

1998 • 295 citations

Evidence that anti–tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: Extended report

2005 • 257 citations

Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate

1984 • 256 citations

Recognition of liposomes by cells: In vitro binding and endocytosis mediated by specific lipid headgroups and surface charge density

1992 • 239 citations

Macrophages of the Splenic Marginal Zone Are Essential for Trapping of Blood-Borne Particulate Antigen but Dispensable for Induction of Specific T Cell Responses

2003 • 231 citations

Demethylation of Promoter Regulatory Elements Contributes to Perforin Overexpression in CD4+ Lupus T Cells

2004 • 220 citations

Synovial macrophage depletion with clodronate‐containing liposomes in rheumatoid arthritis

2000 • 220 citations

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites

1992 • 217 citations

Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro.

1995 • 211 citations

Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.

1995 • 209 citations

Nucleosome‐restricted antibodies are detected before anti‐dsdna and/or antihistone antibodies in serum of mrl‐mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria

1994 • 207 citations

Apoptotic Cells and Innate Immune Stimuli Combine to Regulate Macrophage Cytokine Secretion

2003 • 206 citations

Macrophage Subset Repopulation in the Spleen: Differential Kinetics After Liposome-Mediated Elimination

1989 • 206 citations

Anti-CD40 Ligand Antibody Treatment of SNF1 Mice with Established Nephritis: Preservation of Kidney Function

1998 • 202 citations

Quantitative analysis of liposome-cell interactions in vitro: Rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes

1993 • 199 citations

CLODRONATE LIPOSOMES: PERSPECTIVES IN RESEARCH AND THERAPEUTICS

2002 • 179 citations

Phenotypic and functional similarities between 5‐azacytidine‐treated t cells and a t cell subset in patients with active systemic lupus erythematosus

1992 • 178 citations

The phagocytosis of apoptotic cells

2001 • 164 citations

The key role of nucleosomes in lupus

1999 • 162 citations

Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection

1997 • 162 citations

The Apoptotic Ligands TRAIL, TWEAK, and Fas Ligand Mediate Monocyte Death Induced by Autologous Lupus T Cells

2002 • 160 citations

Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity

2003 • 137 citations

TRAIL (Apo2 Ligand) and TWEAK (Apo3 Ligand) Mediate CD4+ T Cell Killing of Antigen-Presenting Macrophages

2000 • 125 citations

Monocyte Kinetic Studies in Normal and Disease States

1973 • 107 citations

Lupus prone (SWR x NZB)F1 mice produce potentially nephritogenic autoantibodies inherited from the normal SWR parent.

1985 • 107 citations

An ACE inhibitor reduces Th2 cytokines and TGF-β1 and TGF-β2 isoforms in murine lupus nephritis

2004 • 103 citations

Activation of Natural Interferon-α Producing Cells by Apoptotic U937 Cells Combined with Lupus IgG and its Regulation by Cytokines

2001 • 103 citations

The NZB X SWR model of lupus nephritis. II. Autoantibodies deposited in renal lesions show a distinctive and restricted idiotypic diversity.

1987 • 102 citations

Thymine dimer formation as a probe of the path of DNA in and between nucleosomes in intact chromatin.

1989 • 102 citations

Accelerated Fas-Mediated Apoptosis of Monocytes and Maturing Macrophages from Patients with Systemic Lupus Erythematosus: Relevance to In Vitro Impairment of Interaction with iC3b-Opsonized Apoptotic Cells

2001 • 100 citations

Time between onset of apoptosis and release of nucleosomes from apoptotic cells: putative implications for systemic lupus erythematosus

2002 • 97 citations

Circulating DNA in systemic lupus erythematosus. Isolation and characterization.

1984 • 95 citations

Production of Proinflammatory Cytokines by Phorbol Myristate Acetate-Treated THP-1 Cells and Monocyte-Derived Macrophages After Phagocytosis of Apoptotic CTLL-2 Cells

1998 • 95 citations

Mechanism of drug-induced lupus

1988 • 94 citations

Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells

2003 • 92 citations

Role of macrophages in restricting herpes simplex virus type 1 growth after ocular infection.

2000 • 90 citations

Kinetics of Human Monocytopoiesis

1974 • 89 citations

Remnants of suicidal cells fostering systemic autoaggression: Apoptosis in the origin and maintenance of autoimmunity

2000 • 88 citations

Promiscuous Presentation and Recognition of Nucleosomal Autoepitopes in Lupus: Role of Autoimmune T Cell Receptor α Chain

1998 • 84 citations

Apoptosis in systemic lupus erythematosus

2004 • 83 citations

Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model

2002 • 83 citations

Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model

2000 • 73 citations

The NZB X SWR model of lupus nephritis. I. Cross-reactive idiotypes of monoclonal anti-DNA antibodies in relation to antigenic specificity, charge, and allotype. Identification of interconnected idiotype families inherited from the normal SWR and the autoimmune NZB parents.

1987 • 67 citations

Effects of low-dose, noncytotoxic, intraarticular liposomal clodronate on development of erosions and proteoglycan loss in established antigen-induced arthritis in rabbits

2001 • 66 citations

Accumulation of plasma nucleosomes upon treatment with anti‐tumour necrosis factor‐α antibodies

2004 • 63 citations

Induction of apoptosis in monocytes and lymphocytes by serum from patients with systemic lupus erythematosus − an additional mechanism to increased autoantigen load?

2004 • 62 citations

Apoptosis and Altered Dendritic Cell Homeostasis in Lupus Nephritis Are Limited by Anti-CD154 Treatment

2001 • 61 citations

Use of a novel elution regimen reveals the dominance of polyreactive antinuclear autoantibodies in lupus kidneys

2003 • 60 citations

Monocyte apoptosis in patients with active lupus

1996 • 50 citations

Biodistribution of clodronate and liposomes used in the liposome mediated macrophage ‘suicide’ approach

1996 • 45 citations

T cell priming against vesicular stomatitis virus analyzed in situ: red pulp macrophages, but neither marginal metallophilic nor marginal zone macrophages, are required for priming CD4+ and CD8+ T cells.

1997 • 39 citations

Specificity of Monoclonal Anti-nucleosome Auto-antibodies Derived from Lupus Mice

1996 • 39 citations

Enhanced engraftment of human cells in RAG2/γc double-knockout mice after treatment with CL2MDP liposomes

2004 • 37 citations

Mechanisms of drug‐induced lupus. III. Sex‐specific differences in T cell homing may explain increased disease severity in female mice

1997 • 36 citations

B cell apoptosis accelerates the onset of murine lupus

2003 • 34 citations

Autoreactive murine Th1 and Th2 cells kill syngeneic macrophages and induce autoantibodies

2001 • 30 citations

Apoptosis in phagocytotic cells of lymphoid tissues in rainbow trout ( Oncorhynchus mykiss ) following administration of clodronate liposomes

1997 • 23 citations

Concomitant early appearance of anti-ribonucleoprotein and anti-nucleosome antibodies in lupus prone mice

2003 • 23 citations

Treatment with Antibody Reactive with the Nephritogenic Idiotype, IdLNF1, Suppresses its Production and Leads to Prolonged Survival of (NZB × SWR)F1 Mice

1994 • 22 citations

Macrophage Depletion Prevents Leukocyte Adhesion and Disease Induction in Experimental Melanin-protein Induced Uveitis

2001 • 21 citations

Apoptosis and systemic autoimmunity: the dendritic cell connection.

2000 • 17 citations

The onset of nephritis in the (NZB × SWR)F1 murine model for systemic lupus erythematosus correlates with an increase in the ratio of CD4 to CD8 T lymphocytes specific for the nephritogenic idiotype (IdLNF1)

1992 • 16 citations

Brucella abortus causes an accelerated repopulation of the spleen and liver of mice by macrophages after their liposome-mediated depletion

1995 • 11 citations

Molecular Identification of Pathogenetic IdLNF+1 Autoantibody Idiotypes Derived from the (NZB×SWR)F1 Model for Systemic Lupus Erythematosus

2002 • 7 citations

Characteristics of Auto Anti-idiotypic Antibodies Reactive with Antibodies Expressing the Pathogenic Idiotype, IdLNF1, in the (NZB×SWR)F1Model for Lupus Nephritis and its Parental Strains

1998 • 7 citations

Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model

2000 • 6 citations

The Lyb-3+5+ subset of B cells is not required for lupus-like autoantibody formation caused by graft-vs-host reaction.

1985 • 3 citations

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