Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

2004 • 972 citations

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

2005 • 901 citations

Pathogenesis of systemic lupus erythematosus

2003 • 900 citations

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

2005 • 788 citations

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

2005 • 755 citations

Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity

2001 • 694 citations

How we detect microbes and respond to them: the Toll-like receptors and their transducers

2003 • 586 citations

Measurement of increases in anti‐double‐stranded dna antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus

1990 • 558 citations

Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes

2004 • 522 citations

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

2005 • 504 citations

Toll‐like receptors, endogenous ligands, and systemic autoimmune disease

2005 • 391 citations

The immunobiology of the TLR9 subfamily

2004 • 339 citations

Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

2005 • 268 citations

Endosomal Translocation of Vertebrate DNA Activates Dendritic Cells via TLR9-Dependent and -Independent Pathways

2005 • 257 citations

Genetic Modifiers of Systemic Lupus Erythematosus in FcγRIIB−/− Mice

2002 • 250 citations

Toll‐like receptor 9 signaling protects against murine lupus

2005 • 219 citations

Activation of toll‐like receptor‐9 induces progression of renal disease in MRL‐Fas(lpr) mice

2004 • 210 citations

The evolution of human anti-double-stranded DNA autoantibodies

2005 • 194 citations

Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides

1999 • 193 citations

B-lymphocytes, innate immunity, and autoimmunity

2004 • 172 citations

Autoimmunity and Inflammation Due to a Gain-of-Function Mutation in Phospholipase Cγ2 that Specifically Increases External Ca2+ Entry

2005 • 167 citations

Anti–DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern

2002 • 103 citations

Association study of Toll‐like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus

2005 • 89 citations

Initiation of autoimmunity

2004 • 81 citations

B and T cells are not required for the viable motheaten phenotype.

1996 • 79 citations

Diagnostic Accuracy of Elisa Methods as an Alternative Screening Test to Indirect Immunofluorescence for the Detection of Antinuclear Antibodies. Evaluation of Five Commercial Kits

2004 • 63 citations

Highly Immunostimulatory CpG-Free Oligodeoxynucleotides for Activation of Human Leukocytes

2002 • 63 citations

Altered selection processes of B lymphocytes in autoimmune NZB/W mice, despite intact central tolerance against DNA

2001 • 56 citations

Inhibitory oligodeoxynucleotides − therapeutic promise for systemic autoimmune diseases?

2005 • 55 citations

Correlation of DNA-anti-DNA association rates with clinical activity in systemic lupus erythematosus (SLE).

1981 • 48 citations

Synergy between CpG- or non-CpG DNA and specific antigen for B cell activation

2003 • 48 citations

Challenges in bringing the bench to bedside in drug development for sle

2004 • 40 citations

Genetic linkage of systemic lupus erythematosus with chromosome 11q14 (SLEH1) in African-American families stratified by a nucleolar antinuclear antibody pattern

2002 • 29 citations

Regulation of Phospholipase C‐γ2 Networks in B Lymphocytes

2005 • 20 citations

Induction of autoantibody production but not autoimmune disease in HEL transgenic mice vaccinated with HEL in combination with CpG or control oligodeoxynucleotides

2004 • 12 citations