Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin Mice

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Toll-Like Receptors

2003 • 6,127 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

Predominant Autoantibody Production by Early Human B Cell Precursors

2003 • 1,966 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Recognition of pathogen-associated molecular patterns by TLR family

2003 • 1,124 citations

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

2005 • 788 citations

Cellular and genetic mechanisms of self tolerance and autoimmunity

2005 • 671 citations

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

2005 • 649 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

1994 • 541 citations

Activation of Autoreactive B Cells by CpG dsDNA

2003 • 523 citations

Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes

2004 • 522 citations

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

2003 • 512 citations

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8

2005 • 506 citations

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

2005 • 504 citations

T-bet regulates IgG class switching and pathogenic autoantibody production

2002 • 469 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

IgMhighCD21high Lymphocytes Enriched in the Splenic Marginal Zone Generate Effector Cells More Rapidly Than the Bulk of Follicular B Cells

1999 • 364 citations

Speed congenics: a classic technique in the fast lane (relatively speaking)

1997 • 347 citations

TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE

2006 • 340 citations

Contribution of Receptor Editing to the Antibody Repertoire

2001 • 312 citations

CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells

2003 • 291 citations

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

1992 • 281 citations

Residues that mediate DNA binding of autoimmune antibodies.

1993 • 268 citations

Genetic Modifiers of Systemic Lupus Erythematosus in FcγRIIB−/− Mice

2002 • 250 citations

The inhibitory Fcγ receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells

2004 • 245 citations

B Cell Receptor–independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells

2003 • 223 citations

Toll‐like receptor 9 signaling protects against murine lupus

2005 • 219 citations

Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling

2005 • 218 citations

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites

1992 • 217 citations

Editing Disease-Associated Autoantibodies

1997 • 217 citations

Cd5 Maintains Tolerance in Anergic B Cells

2000 • 213 citations

Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice

2004 • 187 citations

Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

2003 • 184 citations

CpG DNA redirects class‐switching towards "Th1‐like" Ig isotype production via TLR9 and MyD88

2004 • 139 citations

T-bet regulates T-independent IgG2a class switching

2003 • 125 citations

Anti–DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern

2002 • 103 citations

The NZB X SWR model of lupus nephritis. II. Autoantibodies deposited in renal lesions show a distinctive and restricted idiotypic diversity.

1987 • 102 citations

Lupus-Specific Antiribonucleoprotein B Cell Tolerance in Nonautoimmune Mice Is Maintained by Differentiation to B-1 and Governed by B Cell Receptor Signaling Thresholds

2001 • 84 citations

Regulation of Anti-DNA B Cells in Recombination-activating Gene–deficient Mice

1998 • 82 citations

Receptor Editing Can Lead to Allelic Inclusion and Development of B Cells That Retain Antibodies Reacting with High Avidity Autoantigens

2005 • 78 citations

The NZB X SWR model of lupus nephritis. I. Cross-reactive idiotypes of monoclonal anti-DNA antibodies in relation to antigenic specificity, charge, and allotype. Identification of interconnected idiotype families inherited from the normal SWR and the autoimmune NZB parents.

1987 • 67 citations

The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models

2003 • 59 citations

The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status

2002 • 38 citations