Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

1986 • 2,118 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 • 1,342 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 • 1,150 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues

1987 • 1,107 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

A ras-like protein is required for a post-Golgi event in yeast secretion

1987 • 894 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway

1992 • 648 citations

A general method for rapid site-directed mutagenesis using the polymerase chain reaction

1990 • 642 citations

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

1988 • 592 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Segregation of transferrin to a mildly acidic (pH 6.5) para-golgi compartment in the recycling pathway

1984 • 586 citations

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

1983 • 558 citations

Do GTPases direct membrane traffic in secretion?

1988 • 540 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Small GTP-Binding Proteins

1992 • 526 citations

GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.

1992 • 497 citations

Movement of internalized ligand–receptor complexes along a continuous endosomal reticulum

1990 • 428 citations

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library.

1987 • 403 citations

Rabphilin-3A, a Putative Target Protein for smg p25A/rab3A p25 Small GTP-Binding Protein Related to Synaptotagmin

1993 • 386 citations

Rab GTPases in vesicular transport

1993 • 379 citations

Friends and family: The role of the rab GTPases in vesicular traffic

1993 • 364 citations

Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.

1993 • 318 citations

A quantitative analysis of the endocytic pathway in baby hamster kidney cells.

1989 • 315 citations

Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic.

1989 • 314 citations

Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.

1990 • 305 citations

Microtubule- and motor-dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cells

1990 • 299 citations

Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies

1991 • 289 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

GTP-binding proteins in intracellular transport

1992 • 277 citations

Rab proteins and the road maps for intracellular transport

1993 • 276 citations

Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.

1990 • 268 citations

Structure-function relationship of the small GTPase rab5.

1993 • 208 citations

Ras Activation by Insulin and Epidermal Growth Factor through Enhanced Exchange of Guanine Nucleotides on p21^ras

1993 • 176 citations

The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins.

1992 • 174 citations

A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family

1993 • 171 citations

Small GTP-binding proteins and their role in transport

1991 • 164 citations

Distinct structural elements of rab5 define its functional specificity.

1994 • 163 citations

Uptake and degradation of glyceraldehyde-3-phosphate dehydrogenase by rat liver lysosomes

1993 • 152 citations

Rab GDI: a solubilizing and recycling factor for rab9 protein.

1993 • 152 citations

The transmembrane segment of the human transferrin receptor functions as a signal peptide.

1986 • 151 citations

Sorting and recycling of cell surface receptors and endocytosed ligands: The asialoglycoprotein and transferrin receptors

1983 • 142 citations

A role for the cytoplasmic domain in transferrin receptor sorting and coated pit formation during endocytosis

1988 • 140 citations

Regulatory Role for GTP-Binding Proteins in Endocytosis

1989 • 138 citations

Reconstitution of vesicle fusions occurring in endocytosis with a cell-free system.

1986 • 132 citations

Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae.

1992 • 132 citations

Two distinct members of the ADP-ribosylation factor family of GTP-binding proteins regulate cell-free intra-golgi transport

1992 • 128 citations

Transferrin receptors promote the formation of clathrin lattices

1991 • 122 citations

Reconstitution of an endocytic fusion event in a cell-free system

1985 • 120 citations

A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4

1993 • 117 citations

DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function

1993 • 112 citations

Mutants of Rab3A analogous to oncogenic Ras mutants. Sensitivity to Rab3A-GTPase activating protein and Rab3A-guanine nucleotide releasing factor

1993 • 92 citations

Mutational analysis of the putative effector domain of the GTP-binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity.

1991 • 91 citations

Characterization of a guanine nucleotide-releasing factor and a GTPase-activating protein that are specific for the ras-related protein p25rab3A.

1992 • 88 citations

Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A

1992 • 82 citations

The role of lipid anchors for small G proteins in membrane trafficking

1992 • 78 citations

Phosphorylation of GDI and membrane cycling of rab proteins

1993 • 51 citations

Hydrolysis of GTP by Sec4 Protein Plays an Important Role in Vesicular Transport and Is Stimulated by a GTPase-Activating Protein in Saccharomyces cerevisiae

1992 • 43 citations

The N-terminal domain of a rab protein is involved in membrane-membrane recognition and/or fusion.

1994 • 41 citations

[37] Localization of Rab family members in animal cells

1992 • 39 citations

Prenylation of Rab5 is dependent on guanine nucleotide binding.

1993 • 38 citations