Evidence for a New Step in Telomere Maintenance

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

1989 • 2,140 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

A theory of marginotomy

1973 • 1,770 citations

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

1988 • 1,734 citations

Origin of Concatemeric T7DNA

1972 • 1,591 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

HELIX FORMATION BY GUANYLIC ACID

1962 • 1,478 citations

Monovalent cation-induced structure of telomeric DNA: The G-quartet model

1989 • 1,202 citations

The localization of replication origins on ARS plasmids in S. cerevisiae

1987 • 1,051 citations

Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops

1989 • 939 citations

An alternative pathway for yeast telomere maintenance rescues est1− senescence

1993 • 916 citations

A mutant with a defect in telomere elongation leads to senescence in yeast

1989 • 905 citations

Telomeres: Beginning to Understand the End

1995 • 855 citations

A sodium-potassium switch in the formation of four-stranded G4-DNA

1990 • 789 citations

Loss of a yeast telomere: Arrest, recovery, and chromosome loss

1993 • 787 citations

[21] β-Galactosidase gene fusions for analyzing gene expression in Escherichia coli and yeast

1983 • 783 citations

pBR322 restriction map derived from the DNA sequence: accurate DNA size markers up to 4361 nucleotide pairs long

1978 • 768 citations

TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase

1994 • 727 citations

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

1990 • 683 citations

Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint

1995 • 632 citations

Crystal structure of four-stranded Oxytricha telomeric DNA

1992 • 556 citations

The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis

1939 • 546 citations

TELOMERASES

1992 • 531 citations

Autoradiography using storage phosphor technology

1990 • 531 citations

Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation

1991 • 530 citations

Extensive 3′-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site

1991 • 525 citations

Quadruplex structure of Oxytricha telomeric DNA oligonucleotides

1992 • 520 citations

All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus.

1981 • 477 citations

The in vivo replication origin of the yeast 2μm plasmid

1987 • 437 citations

Saccharomyces telomeres acquire single-strand TG1–3 tails late in S phase

1993 • 407 citations

Intermediates of recombination during mating type switching in Saccharomyces cerevisiae.

1990 • 405 citations

Telomerase and DNA End Replication: No Longer a Lagging Strand Problem?

1995 • 385 citations

Eukaryotic DNA segments capable of autonomous replication in yeast.

1980 • 366 citations

Runaway telomere elongation caused by telomerase RNA gene mutations

1995 • 338 citations

Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.

1988 • 315 citations

Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNA

1986 • 305 citations

Time of replication of yeast centromeres and telomeres

1988 • 295 citations

An overhanging 3' terminus is a conserved feature of telomeres.

1989 • 286 citations

Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair.

1994 • 275 citations

[46] Analysis of replication intermediates by two-dimensional agarose gel electrophoresis

1995 • 270 citations

Yeast chromosome replication and segregation

1988 • 250 citations

Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediates

1991 • 245 citations

Nonempirical calculations on all the 29 possible DNA base pairs

1987 • 185 citations

Conserved Arrangement of Nested Genes at the Drosophila Gart Locus

1987 • 184 citations

Recombination occurs during telomere formation in yeast

1989 • 169 citations

Construction, replication, and chromatin structure of TRP1 RI circle, a multiple-copy synthetic plasmid derived from Saccharomyces cerevisiae chromosomal DNA.

1982 • 163 citations

Telomere telomere recombination provides an express pathway for telomere acquisition

1990 • 146 citations

Yeast chromosome replication and segregation.

1988 • 115 citations

A novel protein, CSG2p, is required for Ca2+ regulation in Saccharomyces cerevisiae.

1994 • 113 citations

Gene 6 Exonuclease of Bacteriophage T7

1972 • 111 citations

An in vitro assay for saccharomyces telomerase requires EST1

1995 • 111 citations

Telomere structure in Euplotes crassus: characterization of DNA-protein interactions and isolation of a telomere-binding protein.

1990 • 108 citations

[61] Northern and southern blots

1987 • 108 citations

Monovalent cation effects on intermolecular purine-purine-pyrimidine triple-helix formation

1993 • 105 citations

Origin activation and formation of single-strand TG1-3 tails occur sequentially in late S phase on a yeast linear plasmid.

1993 • 101 citations

Quadruplex structure of d(G3T4G3) stabilized by K+ or Na+ is an asymmetric hairpin dimer.

1992 • 98 citations

Introduction of extra telomeric DNA sequences into Saccharomyces cerevisiae results in telomere elongation.

1989 • 95 citations

3 Telomerase Biochemistry and Regulation

1994 • 89 citations

The terminal organization of macronuclear DNA INOxytricha fallax

1982 • 86 citations

A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins.

1993 • 72 citations

Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit.

1993 • 66 citations

Electron microscopy in molecular biology : a practical approach

1987 • 50 citations

Extra telomeres, but not internal tracts of telomeric DNA, reduce transcriptional repression at Saccharomyces telomeres.

1995 • 46 citations

Nucleic acid specificity of a vertebrate telomere-binding protein: evidence for G-G base pair recognition at the core-binding site.

1992 • 44 citations

An Eclectic DNA Structure Adopted by Human Telomeric Sequence Under Superhelical Stress And Low pH

1992 • 40 citations

Lack of positional requirements for autonomously replicating sequence elements on artificial yeast chromosomes.

1989 • 39 citations

RAP1 stimulates single- to double-strand association of yeast telomeric DNA: implications for telomere - telomere interactions

1994 • 36 citations

A 5'-3' Exonuclease From Saccharomyces cerevisiae is Required for in Vitro Recombination Between Linear DNA Molecules with Overlapping Homology

1993 • 34 citations

The Structures of Telomeric DNA

1991 • 25 citations

Use of non-denaturing Southern hybridization and two dimensional agarose gels to detect putative intermediates in telomere replication inSaccharomyces cerevisiae

1992 • 22 citations

A 5'-3' exonuclease from Saccharomyces cerevisiae is required for in vitro recombination between linear DNA molecules with overlapping homology.

1993 • 22 citations

Conducting the G-quartet

1993 • 12 citations

Role of Nucleases in Genetic Recombination

1982 • 10 citations

The acquisition and association of TG1–3 single-strand tails during replication of Saccharomyces telomeres

1993 • 2 citations