Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1997 • 1,244 citations

Control of telomere length by the human telomeric protein TRF1

1997 • 1,197 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Human Keratinocytes That Express hTERT and Also Bypass a p16^INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

2000 • 1,003 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

An alternative pathway for yeast telomere maintenance rescues est1− senescence

1993 • 916 citations

A mutant with a defect in telomere elongation leads to senescence in yeast

1989 • 905 citations

Telomere maintenance by recombination in human cells

2000 • 844 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

TELOMERES AND THEIR CONTROL

2000 • 706 citations

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1999 • 695 citations

A Human Telomeric Protein

1995 • 689 citations

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.

1999 • 659 citations

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1998 • 629 citations

Telomere-Telomere Recombination Is an Efficient Bypass Pathway for Telomere Maintenance in Saccharomyces cerevisiae

1999 • 451 citations

Telomere dynamics in an immortal human cell line.

1994 • 380 citations

Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells

2001 • 239 citations

Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex.

1996 • 230 citations

Mammalian telomeres and telomerase

2000 • 227 citations

NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2 Phases in Immortalized Telomerase-negative Cells

2000 • 210 citations

Telomere maintenance by telomerase and by recombination can coexist in human cells

2001 • 169 citations

Telomerase Activation in Mouse Mammary Tumors: Lack of Detectable Telomere Shortening and Evidence for Regulation of Telomerase RNA with Cell Proliferation

1996 • 157 citations

ALT-associated PML bodies are present in viable cells and are enriched in cells in the G2/M phase of the cell cycle

2000 • 156 citations

Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids

1999 • 107 citations

Telomerase Can Inhibit the Recombination-based Pathway of Telomere Maintenance in Human Cells

2001 • 96 citations

Reconstitution of Wild-Type or Mutant Telomerase Activity in Telomerase-Negative Immortal Human Cells

1998 • 61 citations

Decrease in Amplified Telomeric Sequences and Induction of Senescence Markers by Introduction of Human Chromosome 7 or Its Segments in SUSM-1

1997 • 59 citations