Impaired germinal center reaction in mice with short telomeres

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Structure and function of telomeres

1991 • 3,524 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

1989 • 1,607 citations

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1999 • 1,326 citations

Essential role of mouse telomerase in highly proliferative organs

1998 • 1,256 citations

Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase

1997 • 1,252 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

1998 • 1,206 citations

TELOMERE LENGTH REGULATION

1996 • 1,010 citations

An alternative pathway for yeast telomere maintenance rescues est1− senescence

1993 • 916 citations

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.

1995 • 871 citations

Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

1999 • 798 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

TLC1 : Template RNA Component of Saccharomyces cerevisiae Telomerase

1994 • 727 citations

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

1999 • 658 citations

The rate of telomere sequence loss in human leukocytes varies with age

1998 • 652 citations

Myc activates telomerase

1998 • 650 citations

Isolation of a Candidate Human Telomerase Catalytic Subunit Gene, Which Reveals Complex Splicing Patterns in Different Cell Types

1997 • 586 citations

Telomeres in the mouse have large inter-chromosomal variations in the number of T ₂ AG ₃ repeats

1997 • 490 citations

Human telomerase contains evolutionarily conserved catalytic and structural subunits

1997 • 476 citations

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

1999 • 462 citations

The telomerase reverse transcriptase: components and regulation

1998 • 435 citations

Short telomeres on human chromosome 17p

1998 • 367 citations

Functional Characterization and Developmental Regulation of Mouse Telomerase RNA

1995 • 366 citations

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

1997 • 344 citations

Runaway telomere elongation caused by telomerase RNA gene mutations

1995 • 338 citations

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

1998 • 332 citations

Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice

1999 • 322 citations

Life and Death in Germinal Centers (Redux)

1996 • 315 citations

Two Modes of Survival of Fission Yeast Without Telomerase

1998 • 289 citations

Telomere lengthening and telomerase activation during human B cell differentiation

1997 • 263 citations

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

1999 • 234 citations

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.

1996 • 226 citations

Immunosenescence and germinal center reaction

1997 • 226 citations

Expression of mouse telomerase catalytic subunit in embryos and adult tissues

1998 • 216 citations

Stringent sequence requirements for the formation of human telomeres.

1994 • 190 citations

The Telomere Lengthening Mechanism in Telomerase-Negative Immortal Human Cells Does Not Involve the Telomerase RNA Subunit

1997 • 189 citations

Telomerase and cancer: revisiting the telomere hypothesis

1996 • 167 citations

Severe growth defect in mouse cells lacking the telomerase RNA component

1998 • 159 citations

Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas

1996 • 154 citations

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube

1999 • 142 citations

Immunological memory

1997 • 124 citations

To ‘B’ or not to ‘B’ a germinal center?

1997 • 114 citations

Telomere Length, Aging, and Somatic Cell Turnover

1999 • 108 citations

Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro.

1997 • 98 citations

Expression of the RNA component of telomerase during human development and differentiation.

1998 • 67 citations