Amelioration of experimental colitis by Copaxone is associated with class-II-restricted CD4 immune blocking

Inflammatory Bowel Disease

2002 • 3,038 citations

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

Inflammatory bowel disease: Etiology and pathogenesis

1998 • 2,095 citations

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

The immunological and genetic basis of inflammatory bowel disease

2003 • 1,766 citations

The Immunology of Mucosal Models of Inflammation

2002 • 1,323 citations

The unconventional lifestyle of NKT cells

2002 • 756 citations

Role of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

2000 • 714 citations

European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging--measured disease activity and burden in patients with relapsing multiple sclerosis. European/Canadian Glatiramer Acetate Study Group.

2001 • 697 citations

The Regulatory Role of Vα14 NKT Cells in Innate and Acquired Immune Response

2003 • 673 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

European/Canadian multicenter, double‐blind, randomized, placebo‐controlled study of the effects of glatiramer acetate on magnetic resonance imaging–measured disease activity and burden in patients with relapsing multiple sclerosis

2001 • 595 citations

Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability

1998 • 504 citations

A Pilot Trial of Cop 1 in Exacerbating–Remitting Multiple Sclerosis

1987 • 465 citations

CD1d-restricted Recognition of Synthetic Glycolipid Antigens by Human Natural Killer T Cells

1998 • 445 citations

CURRENT CONCEPTS OF THE ETIOLOGY AND PATHOGENESIS OF ULCERATIVE COLITIS AND CROHN’S DISEASE

1995 • 398 citations

Progress in determining the causes and treatment of multiple sclerosis

1999 • 280 citations

Mechanisms of action of glatiramer acetate in multiple sclerosis

2001 • 252 citations

Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells--specificity and promiscuity.

1994 • 243 citations

Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes

2004 • 231 citations

Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease

1997 • 228 citations

Glatiramer Acetate (Copolymer-1, Copaxone) Promotes Th2 Cell Development and Increased IL-10 Production Through Modulation of Dendritic Cells

2003 • 215 citations

Activation of natural killer T cells by α-galactosylceramide in the presence of CD1d provides protection against colitis in mice

2000 • 210 citations

Copolymer 1 acts against the immunodominant epitope 82–100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking

1999 • 191 citations

Glatiramer acetate (Copaxone) therapy induces CD8+ T cell responses in patients with multiple sclerosis

2002 • 179 citations

Glatiramer acetate (Copaxone) therapy induces CD8+ T cell responses in patients with multiple sclerosis

2002 • 176 citations

Inflammatory bowel disease: new insights into pathogenesis and treatment

2002 • 172 citations

G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines.

1997 • 169 citations

A Role for NK Cells as Regulators of CD4+ T Cells in a Transfer Model of Colitis

1998 • 162 citations

Mechanisms of immunomodulation by glatiramer acetate

2000 • 161 citations

Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment

2001 • 137 citations

Experimental autoimmune encephalomyelitis in the rat: lessons in T‐cell immunology and autoreactivity

2001 • 134 citations

Circulating CD4⁺CD25⁺T Regulatory Cells Are Not Altered in Multiple Sclerosis and Unaffected by Disease-Modulating Drugs

2004 • 125 citations

Glatiramer acetate-reactive T cells produce brain-derived neurotrophic factor

2003 • 118 citations

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.

1988 • 115 citations

Synthetic copolymer 1 inhibits human T-cell lines specific for myelin basic protein.

1992 • 111 citations

Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model

1999 • 102 citations

Enteric bacterial antigens activate CD4+ T cells fromscid mice with inflammatory bowel disease

2001 • 90 citations

Single Dose of OOCH Improves Mucosal T Helper Type 1/T Helper Type 2 Cytokine Balance and Prevents Experimental Colitis in the Presence of Vα14 Natural Killer T Cells in Mice

2005 • 82 citations

Effect of glatiramer acetate (Copaxone) on CD4+CD25high T regulatory cells and their IL-10 production in multiple sclerosis

2003 • 77 citations

Human and Murine CD4 T Cell Reactivity to a Complex Antigen: Recognition of the Synthetic Random Polypeptide Glatiramer Acetate

2000 • 72 citations

Immunomodulation by the copolymer glatiramer acetate

2003 • 71 citations

Induction of IL-10 in rat peritoneal macrophages and dendritic cells by glatiramer acetate

2004 • 69 citations

Immunotherapy of multiple sclerosis: Where are we? Where should we go?

2001 • 68 citations

Treatment of experimental colitis by oral tolerance induction: a central role for suppressor lymphocytes

2000 • 65 citations

New insights into the mechanism of action of copolymer 1 of action of copolymer 1 in experimental allergic encephalomyelitis and multiple sclerosis

1996 • 61 citations

Binding Motifs of Copolymer 1 to Multiple Sclerosis- and Rheumatoid Arthritis-Associated HLA-DR Molecules

1999 • 57 citations

A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo.

1996 • 45 citations

Copolymer 1 inhibits experimental autoimmune uveoretinitis

2000 • 42 citations

A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4⁺T cells

2003 • 42 citations

MHC-II-Independent CD4+ T Cells Induce Colitis in Immunodeficient RAG−/− Hosts

2001 • 40 citations

NK 1.1+ T cell: a two-faced lymphocyte in immune modulation of the IL-4/IFN-gamma paradigm.

2002 • 36 citations

Therapeutic Effect of the Immunomodulator Glatiramer Acetate on Trinitrobenzene Sulfonic Acid-Induced Experimental Colitis

2005 • 32 citations

COPOLYMER 1 INHIBITS MANIFESTATIONS OF GRAFT REJECTION1

2001 • 32 citations

Adoptive transfer of ex vivo immune-programmed NKT lymphocytes alleviates immune-mediated colitis

2003 • 27 citations

Inflammatory bowel disease: pathogenesis and targets for therapeutic interventions

2001 • 26 citations

Cells and Cytokines in the Pathogenesis of Inflammatory Bowel Disease: New Insights from Mouse T Cell Transfer Models

2000 • 13 citations

Treatment of experimental colitis through induction of oral tolerance towards colitis-extracted proteins

1998 • 12 citations