Effect of glatiramer acetate (Copaxone) on CD4+CD25high T regulatory cells and their IL-10 production in multiple sclerosis

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis

2000 • 412 citations

Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

2003 • 392 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

1992 • 375 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

2000 • 304 citations

Mechanisms of action of glatiramer acetate in multiple sclerosis

2001 • 252 citations

Characterization of human CD25⁺ CD4⁺ T cells in thymus, cord and adult blood

2002 • 232 citations

Treatment of multiple sclerosis with Copolymer-1 (Copaxone®): implicating mechanisms of Th1 to Th2/Th3 immune-deviation

1998 • 226 citations

Mechanisms of action of interferons and glatiramer acetate in multiple sclerosis

2002 • 183 citations

Mechanisms of immunomodulation by glatiramer acetate

2000 • 161 citations

Synthetic copolymer 1 inhibits human T-cell lines specific for myelin basic protein.

1992 • 111 citations

The development of Cop 1 (Copaxone®), and innovative drug for the treatment of multiple sclerosis: personal reflections

1996 • 94 citations

Glatiramer acetate and IFN-β act on dendritic cells in multiple sclerosis

2001 • 89 citations

Glatiramer acetate in the treatment of multiple sclerosis

2001 • 71 citations

Dendritic cells derived from patients with multiple sclerosis show high CD1a and low CD86 expression

2001 • 44 citations

Binding of copolymer 1 and myelin basic protein leads to clustering of class II MHC molecules on antigen-presenting cells

1997 • 36 citations

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