Glatiramer acetate (Copaxone) therapy induces CD8+ T cell responses in patients with multiple sclerosis

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution

2000 • 679 citations

Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency.

1997 • 560 citations

Primary progressive multiple sclerosis

1997 • 505 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide

1971 • 431 citations

Multiple Sclerosis

1982 • 415 citations

Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis

2000 • 412 citations

Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 ^-/- Mice

1992 • 359 citations

Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

2000 • 304 citations

Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis

1997 • 280 citations

Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells.

1998 • 267 citations

Mechanisms of action of glatiramer acetate in multiple sclerosis

2001 • 252 citations

Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells--specificity and promiscuity.

1994 • 243 citations

Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years

2000 • 233 citations

Treatment of multiple sclerosis with Copolymer-1 (Copaxone®): implicating mechanisms of Th1 to Th2/Th3 immune-deviation

1998 • 226 citations

Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1

2000 • 222 citations

ORAL TOLERANCE FOR THE TREATMENT OF AUTOIMMUNE DISEASES

1997 • 193 citations

Copolymer 1 acts against the immunodominant epitope 82–100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking

1999 • 191 citations

Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1

1998 • 176 citations

Diversity and plasticity of self recognition during the development of multiple sclerosis.

1997 • 164 citations

Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: Epitope spreading versus clonal persistence

2000 • 161 citations

Mechanisms of immunomodulation by glatiramer acetate

2000 • 161 citations

Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis

1992 • 134 citations

Humoral and cellular immune responses to Copolymer 1 in multiple sclerosis patients treated with Copaxone®

2001 • 128 citations

Suppression of experimental allergic encephalomyelitis in rhesus monkeys by a synthetic basic copolymer

1974 • 127 citations

CD8⁺T cells control the TH phenotype of MBP-reactive CD4⁺T cells in EAE mice

2001 • 124 citations

Suppression by several synthetic polypeptides of experimental allergic encephalomyelitis induced in guinea pigs and rabbits with bovine and human basic encephalitogen

1973 • 123 citations

Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.

1995 • 116 citations

Treatment of multiple sclerosis with Copaxone (COP): Elispot assay detects COP-induced interleukin-4 and interferon-gamma response in blood cells

2001 • 115 citations

Synthetic copolymer 1 inhibits human T-cell lines specific for myelin basic protein.

1992 • 111 citations

Interferon-? secretion by peripheral blood T-cell subsets in multiple sclerosis: Correlation with disease phase and interferon-? therapy

1999 • 95 citations

Effect of a synthetic polypeptide (Cop 1) on patients with multiple sclerosis and with acute disseminated encephalomyelitis

1977 • 94 citations

Multiple sclerosis: Trial of a synthetic polypeptide

1982 • 91 citations

Brefeldin A, but not monensin, completely blocks CD69 expression on mouse lymphocytes:

1999 • 90 citations

Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients

1995 • 88 citations

Copolymer-1-induced inhibition of antigen-specific T cell activation: interference with antigen presentation

1992 • 81 citations

Oral Administration of Myelin Induces Antigen‐specific TGF‐β1 Secreting T Cells in Patients with Multiple Sclerosis^a

1997 • 80 citations

Human and Murine CD4 T Cell Reactivity to a Complex Antigen: Recognition of the Synthetic Random Polypeptide Glatiramer Acetate

2000 • 72 citations

Characterization of T cell lines derived from glatiramer-acetate-treated multiple sclerosis patients

2000 • 70 citations

The effect of Cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs

1979 • 59 citations

Defective suppressor cell function mediated by T8+ cell lines from patients with progressive multiple sclerosis.

1986 • 59 citations

Binding Motifs of Copolymer 1 to Multiple Sclerosis- and Rheumatoid Arthritis-Associated HLA-DR Molecules

1999 • 57 citations

Etretinate Augments Interferon Beta-1b Effects on Suppressor Cells in Multiple Sclerosis

2001 • 24 citations