Genetic landmarks for defects in mouse neural tube closure

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Smith's Recognizable Patterns of Human Malformation

1998 • 1,959 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

1995 • 702 citations

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

1991 • 664 citations

Longitudinal organization of the anterior neural plate and neural tube

1995 • 647 citations

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

1996 • 646 citations

Transcription factor AP-2 essential for cranial closure and craniofacial development

1996 • 611 citations

twist is required in head mesenchyme for cranial neural tube morphogenesis.

1995 • 595 citations

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

1996 • 595 citations

A subset of p53-deficient embryos exhibit exencephaly

1995 • 577 citations

Genetical studies on the skeleton of the mouse

1954 • 560 citations

The MARCKS family of cellular protein kinase C substrates.

1993 • 484 citations

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1996 • 468 citations

High-frequency developmental abnormalities in p53-deficient mice

1995 • 464 citations

Constitutive activation of Src family kinases in mouse embryos that lack Csk

1993 • 401 citations

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

1993 • 394 citations

The embryonic development of mammalian neural tube defects

1990 • 337 citations

The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages.

1995 • 333 citations

Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation.

1995 • 329 citations

Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp 2H) mutant

1997 • 313 citations

Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements.

1994 • 301 citations

MARCKS deficiency in mice leads to abnormal brain development and perinatal death.

1995 • 291 citations

Analysis of the developmental effects of a lethal mutation in the house mouse

1954 • 290 citations

Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene

1996 • 273 citations

Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.

1995 • 258 citations

Neural tube defects: A review of human and animal studies on the etiology of neural tube defects

1986 • 249 citations

Inositol prevents folate-resistant neural tube defects in the mouse

1997 • 219 citations

Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction gene

1997 • 215 citations

Congenital vertebral anomalies: aetiology and relationship to spina bifida cystica.

1975 • 195 citations

A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant.

1993 • 180 citations

Extra-toes: anew mutant gene causing multiple abnormalities in the mouse.

1967 • 172 citations

Comparative Genome Organization of Vertebrates

1996 • 144 citations

Clinical, genetic, and epidemiological factors in neural tube defects.

1988 • 139 citations

Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice.

1993 • 123 citations

Intermittent pattern of neural tube closure in two strains of mice

1993 • 119 citations

apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes.

1995 • 118 citations

Multifactorial inheritance of neural tube defects: localization of the major gene and recognition of modifiers in ct mutant mice

1994 • 118 citations

Neurulation in the mouse: Manner and timing of neural tube closure

1989 • 115 citations

open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord

1994 • 102 citations

Prevalence and patterns of spina bifida occulta in 2707 normal adults

1987 • 100 citations

The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex

1997 • 100 citations

Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly.

1996 • 94 citations

Neural tube defects and abnormal brain development in F52-deficient mice.

1996 • 94 citations

Developmental study of neural tube closure in a mouse stock with a high incidence of exencephaly

1989 • 93 citations

The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development

1994 • 88 citations

Spina bifida occulta: Lesion or anomaly?

1985 • 86 citations

Genetical studies on the skeleton of the mouse

1953 • 81 citations

Sex, neural tube defects, and multisite closure of the human neural tube

1995 • 81 citations

Developmental Basis of Severe Neural Tube Defects in the loop-tail (Lp) Mutant Mouse: Use of Microsatellite DNA Markers to Identify Embryonic Genotype

1994 • 79 citations

Extra-Toes (Xt) Homozygous Mutant Mice Demonstrate a Role for the Gli-3 Gene in the Development of the Forebrain

1994 • 77 citations

Neural tube defects in curly-tail mice. I. Incidence, expression and similarity to the human condition

1979 • 75 citations

Exencephaly and hydrocephaly in mice with targeted modification of the Apolipoprotein B (Apob) gene

1995 • 74 citations

The inheritance and expression of disorganization, an unusual mutation in the mouse

1958 • 71 citations

Etiologic heterogeneity of neural tube defects. II. Clues from family studies.

1982 • 70 citations

Splotch locus mouse mutants: models for neural tube defects and Waardenburg syndrome type I in humans.

1992 • 69 citations

Value of an animal model for trisomy

1982 • 67 citations

A Curly-Tail Modifier Locus,mct1,on Mouse Chromosome 17

1995 • 60 citations

Encyclopedia of the mouse genome III

1993 • 58 citations

Prevention of spinal neural tube defects in the mouse embryo by growth retardation during neurulation

1988 • 57 citations

NEW SPLOTCH ALLELES IN THE MOUSE

1964 • 56 citations

Comparative maps of vertebrates

1996 • 55 citations

Spina bifida occulta.

1979 • 55 citations

The Splotch (Sp1H) and Splotch-delayed (Spd) alleles: differential phenotypic effects on neural crest and limb musculature

1993 • 53 citations

Spinal ganglia reduction in the splotch‐delayed mouse neural tube defect mutant

1989 • 49 citations

The morphological effects and the development of the fused mutation in the mouse

1956 • 46 citations

Spina bifida cystica. Incidence of spina bifida occulta in parents and in controls.

1967 • 44 citations

Severe defects in the formation of epaxial musculature in open brain (opb) mutant mouse embryos

1996 • 44 citations

Female predisposition to cranial neural tube defects is not because of a difference between the sexes in the rate of embryonic growth or development during neurulation.

1994 • 44 citations

Genetic analysis of the cause of exencephaly in the SELH/Bc mouse stock

1989 • 40 citations

A new crooked tail mutation involving distinctive pleiotropism

1954 • 40 citations

Maternal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants

1992 • 39 citations

A mouse model for neural tube defects: The Curtailed (T^c) mutation produces spina bifida occulta in T^c/ + animals and spina bifida with meningomyelocele in T^c/t

1989 • 35 citations

Abnormal neural fold development in trisomy 12 and trisomy 14 mouse embryos

1981 • 34 citations

Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age

1990 • 32 citations

Sodium valproate augments spontaneous neural tube defects and axial skeletal malformations into mouse fetuses

1996 • 32 citations

Embryology of the Little & Bagg

1959 • 31 citations

Reduction in the frequency of neural tube defects in splotch mice by retinoic acid

1985 • 30 citations

Brachyphalangy, an allele of extra-toes in the mouse

1969 • 30 citations

Disorganization is a completely dominant gain-of-function mouse mutation causing sporadic developmental defects

1992 • 29 citations

Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21–q23

1995 • 29 citations

Doublefoot: a new mouse mutant affecting development of limbs and head

1996 • 28 citations

Head blebs: a new mutation on chromosome 4 of the mouse

1981 • 27 citations

Forebrain overgrowth (fog): A new mutation in the mouse affecting neural tube development

1997 • 27 citations

Retinoic acid‐induced selective mortality of splotch‐delayed mouse neural tube defect mutants

1987 • 27 citations

The development of rib fusions, a mutation in the house mouse

1960 • 27 citations

The interfrontal bone and mutant genes in the mouse.

1976 • 24 citations

Comparative genome mapping in mammals

1994 • 23 citations

Comparison of the incidence of 5‐azacytidine‐induced exencephaly between MT/HokIdr and Slc:ICR mice

1990 • 23 citations

Genetics of the little and bagg X-rayed mouse stock

1956 • 23 citations

Pathogenesis of Neural Dysraphism in the Mouse Mutant Vacuolated Lens (vl)

1986 • 22 citations

Chromosomal mapping of the human (MACS) and mouse (Macs) genes encoding the MARCKS protein

1992 • 22 citations

High-resolution linkage map in the vicinity of the Lp locus

1995 • 19 citations

BRAIN HERNIA, A NEW RECESSIVE MUTATION IN THE MOUSE

1959 • 18 citations

Effect of pre-treatment with aspirin on alcohol-induced neural tube defects in the TO mouse fetuses

1994 • 17 citations

Haplotype analysis of intra-specific backcross curly-tail mice confirms the localization of ct to Chromosome 4

1995 • 17 citations

Inheritance and morphology of exencephaly, a neonatal lethal recessive with partial penetrance, in the house mouse

1978 • 17 citations

Genetic spina bifida occulta in the mouse

1976 • 16 citations

Further genetic studies of the cause of exencephaly in SELH mice

1992 • 16 citations

Abnormal neurol fold development in mouse trisomy 12 and trisomy 14. II. LM and TEM

1986 • 14 citations

Spina Bifida Occulta

1993 • 13 citations

Development of the cerebellar defect in ataxic SELH/Bc mice

1994 • 12 citations

New Zealand white mice: an experimental model of exencephaly.

1993 • 10 citations

Ataxia and a cerebellar defect in the exencephaly‐prone SELH/Bc mouse stock

1993 • 10 citations

Physical and Genetic Localization of the Gene Encoding the AP-2 Transcription Factor to Mouse Chromosome 13

1996 • 7 citations

Chromosome Translocation (T(2;4)1 Sn)-Induced Neural Tube Defects in the Mouse Embryo

1983 • 6 citations

The open brain (opb) mutation maps to mouse chromosome 1

1997 • 6 citations

Exencephaly and cleft cerebellum in SELH/Bc mouse embryos are alternative developmental consequences of the same underlying genetic defect

1996 • 5 citations

Effects of H-2 on Neural Tube Defects in Congenic Mice

1992 • 4 citations

THE MODE OF DEVELOPMENT OF AN INHERITED FORM OF ANENCEPHALY IN THE HOUSE MOUSE

1981 • 4 citations

Genetic and developmental studies of abnormal neural tube closure in SELH/Bc mice

1995 • 3 citations

[Incidence of spina bifida occulta in relatives of children with myelodysplasia. Indications for high-risk screening].

1985 • 3 citations

Assignment of the human connexin43 gene,GJA1, to chromosome 6q22.3

1997 • 2 citations