The embryonic development of mammalian neural tube defects

A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron-microscopy

1965 • 5,043 citations

Retinoic Acid Embryopathy

1985 • 1,921 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

The developing human

1988 • 912 citations

The Migration and Differentiation of Neural Crest Cells

1970 • 814 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.

1981 • 678 citations

Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects

1989 • 629 citations

Vitamin dificiencies and neural tube defects.

1976 • 580 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

1989 • 566 citations

Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse

1989 • 511 citations

Periconceptional Use of Multivitamins and the Occurrence of Neural Tube Defects

1988 • 487 citations

Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse

1989 • 482 citations

Normal and abnormal development of the human nervous system

1975 • 405 citations

Normal and abnormal development of the human nervous system

1976 • 403 citations

A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1.

1989 • 399 citations

Appearance and distribution of collagens and laminin in the early mouse embryo

1980 • 395 citations

Apparent prevention of neural tube defects by periconceptional vitamin supplementation.

1981 • 389 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

PROTEOGLYCAN CORE PROTEIN FAMILIES

1986 • 367 citations

Dietary folate as a risk factor for neural‐tube defects: evidence from a case‐control study in Western Australia

1989 • 353 citations

RECOMBINANT INBRED STRAINS: USE IN GENE MAPPING

1978 • 351 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

Results of treatment of myelomeningocele. An analysis of 524 unselected cases, with special reference to possible selection for treatment.

1971 • 335 citations

Expression of homeo box genes during mouse development: a review.

1988 • 331 citations

Excessive Intake of Vitamin A as a Cause of Congenital Anomalies in the Rat

1953 • 323 citations

Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development

1988 • 304 citations

Changes in the shape of the developing vertebrate nervous system analyzed experimentally, mathematically and by computer simulation

1976 • 294 citations

Definition of insanity.

1984 • 292 citations

Analysis of the developmental effects of a lethal mutation in the house mouse

1954 • 290 citations

Valproic acid

1987 • 290 citations

Expression of nidogen and laminin in basement membranes during mouse embryogenesis and in teratocarcinoma cells

1985 • 272 citations

The Mechanisms of Neural Tube Formation

1974 • 267 citations

Formation of Cytoskeletal Elements During Mouse Embryogenesis

1982 • 259 citations

Hypervitaminosis A Induced Teratogenesis

1979 • 257 citations

The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects

1989 • 256 citations

Etiologic Heterogeneity of Neural-Tube Defects

1976 • 248 citations

The development of the human brain, the closure of the caudal neuropore, and the beginning of secondary neurulation at stage 12

1987 • 233 citations

Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain.

1988 • 225 citations

Expression of the cell surface-associated glycoprotein, fibronectin, in the early mouse embryo

1979 • 225 citations

Histological and ultrastructural studies of secondary neurulation in mouse embryos

1984 • 225 citations

Formation of cytoskeletal elements during mouse embryogenesis

1984 • 218 citations

A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube

1988 • 208 citations

Histochemical localization of IGF-I and -II mRNA in the developing rat embryo

1987 • 193 citations

Teratogenic effects of excess glucose on head‐fold rat embryos in culture

1977 • 191 citations

ETIOLOGIC HETEROGENEITY OF NEURAL TUBE DEFECTS: CLUES FROM EPIDEMIOLOGY1

1982 • 189 citations

Effect of oxygen concentration on morphogenesis of cranial neural folds and neural crest in cultured rat embryos

1979 • 187 citations

Spontaneous high expression of heat-shock proteins in mouse embryonal carcinoma cells and ectoderm from day 8 mouse embryo.

1983 • 187 citations

Altered sex ratio of live young after transfer of fast‐ and slow‐developing mouse embryos

1985 • 177 citations

Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo.

1989 • 172 citations

Extra-toes: anew mutant gene causing multiple abnormalities in the mouse.

1967 • 172 citations

Teratogenicity of valproic acid: In vivo and in vitro investigations

1981 • 162 citations

Some aspects of the development of the notochord in mouse embryos

1974 • 158 citations

Lysosomal Enzyme Inhibition by Trypan Blue: A Theory of Teratogenesis

1967 • 152 citations

The Honeybee Syndrome — Implications of the Teratogenicity of Mannose in Rat-Embryo Culture

1984 • 151 citations

Clues to the Aetiology of Neural Tube Malformations*

1974 • 148 citations

A transgene insertional mutation at an imprinted locus in the mouse genome

1990 • 147 citations

Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A.

1972 • 146 citations

A gene with sequence similarity to Drosophila engrailed is expressed during the development of the neural tube and vertebrae in the mouse

1988 • 144 citations

The localization and synthesis of some collagen types in developing mouse embryos

1979 • 142 citations

CAUSATION OF NEURAL TUBE DEFECTS: CLUES FROM EPIDEMIOLOGY

1974 • 141 citations

Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses

1983 • 139 citations

A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryos developing spinal neural tube defects

1988 • 139 citations

Clinical, genetic, and epidemiological factors in neural tube defects.

1988 • 139 citations

Relationship of transformation, cell density, and growth control to the cellular distribution of newly synthesized glycosaminoglycan.

1976 • 136 citations

Hyperthermia as a teratogen: Parameters determining hyperthermia‐induced head defects in the rat

1985 • 135 citations

Amphibian neural crest cell migration on purified extracellular matrix components: a chondroitin sulfate proteoglycan inhibits locomotion on fibronectin substrates.

1987 • 132 citations

Topographical changes along the neural fold associated with neurulation in the hamster and mouse

1976 • 130 citations

Strain differences in heat‐induced neural tube defects in mice

1986 • 126 citations

Neural tube defects and sex ratios

1987 • 126 citations

Heat shock and thermotolerance during early rat embryo development

1987 • 126 citations

Closure of the neural tube in the cephalic region of the mouse embryo

1977 • 125 citations

Epidemiology of Anencephalus and Spina Bifida

1980 • 125 citations

Spatial and temporal pattern of expression of the cellular retinoic acid-binding protein and the cellular retinol-binding protein during mouse embryogenesis.

1989 • 123 citations

Teratogenicity of sodium arsenate in rats

1974 • 123 citations

Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4‐propyl‐4‐pentenoic acid metabolite

1988 • 121 citations

Neurulation and the cortical tractor model for epithelial folding

1986 • 120 citations

Retinoic acid-induced spina bifida: evidence for a pathogenetic mechanism

1990 • 120 citations

Cell cycle and neuroepithelial cell shape during bending of the chick neural plate

1987 • 118 citations

Cephalic neurulation in the mouse embryo analyzed by SEM and morphometry

1982 • 117 citations

Neurulation in the mouse: Manner and timing of neural tube closure

1989 • 115 citations

An SEM analysis of neural crest migration in the mouse

1983 • 112 citations

Desmin and titin expression in early postimplantation mouse embryos

1989 • 107 citations

Mesodermal alterations induced by hypervitaminosis A

1966 • 106 citations

Growth and development of pattern in the cranial neural epithelium of rat embryos during neurulation

1981 • 105 citations

Changes in the mouse neuroepithelium associated with cadmium-induced neural tube defects

1980 • 105 citations

Sex difference in mouse embryonic development at neurulation

1987 • 105 citations

Gene‐teratogen interaction in insulin‐induced mouse exencephaly

1980 • 103 citations

Glycosaminoglycan synthesis in rat embryos during the formation of the primary mesenchyme and neural folds

1977 • 102 citations

Calcium and neurulation in mammalian embryos

1985 • 101 citations

Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice.

1982 • 98 citations

A preliminary report on hydrocephalus, spina bifida and other congenital anomalies in the rat produced by trypan blue; the significance of these results in the interpretation of congenital malformations following maternal rubella.

1948 • 97 citations

Teratogenic effects of hypoglycemic treatments in inbred strains of mice

1963 • 97 citations

Cell adhesion and proteoglycans: I. the effect of exogenous proteoglycans on the attachment of chick embryo fibroblasts to tissue culture plastic and collagen

1979 • 97 citations

Periconceptional use of multivitamins and the occurrence of neural tube defects

1988 • 96 citations

Teratogenic effects of valproic acid and diphenylhydantoin on mouse embryos in culture

1983 • 96 citations

Regional differences in mesenchymal cell morphology and glycosaminoglycans in early neural-fold stage rat embryos

1978 • 95 citations

Genetical studies on the skeleton of the mouse

1954 • 95 citations

Hyperthermia and the induction of neural tube defects in mice

1984 • 95 citations

Valproic acid-induced neural tube defects: Reduction by folinic acid in the mouse

1987 • 95 citations

Notochordal–basichondrocranium relationships: abnormalities in experimental axial skeletal (dysraphic) disorders

1979 • 93 citations

A reexamination of the role of microfilaments in neurulation in the chick embryo

1988 • 93 citations

Villin expression in the visceral endoderm and in the gut anlage during early mouse embryogenesis.

1988 • 93 citations

Developmental study of neural tube closure in a mouse stock with a high incidence of exencephaly

1989 • 93 citations

Actin Distribution Patterns in the Mouse Neural Tube During Neurulation

1982 • 90 citations

EARLY TERMINATION OF ANENCEPHALIC PREGNANCY AFTER DETECTION BY RAISED ALPHA-FETOPROTEIN LEVELS

1973 • 89 citations

Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster

1967 • 87 citations

Ultrastructural observations on closure of the neural tube in the mouse

1979 • 87 citations

The role of microfilaments in cranial neurulation in rat embryos: effects of short-term exposure to cytochalasin D

1985 • 87 citations

Mitotic cell death and delay of mitotic activity in guinea-pig embryos following brief maternal hyperthermia

1974 • 85 citations

Induction of Neural Tube Defects and Skeletal Malformations in Mice following Brief Hyperthermia in utero

1988 • 84 citations

Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation?

1989 • 84 citations

Exencephaly in fetal hamsters following exposure to hyperthermia

1976 • 83 citations

Induction of hyaluronic acid synthetase activity in rat fibroblasts by medium change of confluent cultures

1975 • 83 citations

Embryotoxic effects of sodium arsenite and sodium arsenate on mouse embryos in culture

1990 • 83 citations

Variations in development of the caudal neural tube in human embryos (Horizons XIV–XXI)

1969 • 82 citations

The induction of microphthalmia, encephalocele, and other head defects following hyperthermia during the gastrulation process in the rat

1985 • 81 citations

Hyaluronate synthetase inhibition by normal and transformed human fibroblasts during growth reduction

1987 • 81 citations

A comparative study of the effects or retinoic acid given during the critical period for inducing spina bifida in mice and hamsters

1988 • 79 citations

Embryonic stress hypothesis of teratogenesis

1984 • 79 citations

Cell Death and Reduced Proliferative Rate

1977 • 78 citations

Treatment of draconti-asis with niridazole.

1967 • 76 citations

Teratogenic Effects of Cyclopamine and Jervine in Rats, Mice and Hamsters

1975 • 75 citations

Neural tube defects in curly-tail mice. II. Effect of maternal administration of vitamin A

1979 • 75 citations

Developmental Abnormalities in the Rat Induced by Heat Shock

1963 • 74 citations

The head-process and the formation of the definitive endoderm in the mouse embryo

1981 • 74 citations

The distribution of fibronectin, laminin and entactin in the neurulating rat embryo studied by indirect immunofluorescence

1986 • 73 citations

Epidemiology of Anencephalus and Spina Bifida,

1981 • 73 citations

Hyperthermia-induced heat shock response and thermotolerance in postimplantation rat embryos

1987 • 72 citations

The ultrastructural effects of excess maternal vitamin A on the primitive streak stage rat embryo

1973 • 72 citations

Origin of the dorsal surface of the neural tube by progressive delamination of epidermal ectoderm and neuroepithelium: implications for neurulation and neural tube defects

1988 • 72 citations

Inhibition of pinocytosis in rat yolk sac by trypan blue

1976 • 72 citations

Teratogenic effects of 27.12 MHz radiofrequency radiation in rats

1982 • 71 citations

Changes with gestational age in the nutritional requirements of postimplantation rat embryos in culture

1988 • 71 citations

EARLY PRENATAL DIAGNOSIS OF ANENCEPHALY

1972 • 70 citations

The teratogenic response of mouse embryos to 5‐bromodeoxyuridine

1971 • 69 citations

Possible causal heterogeneity in spina bifida cystica

1985 • 69 citations

Somite necrosis and developmental malformations induced by vitamin A in the golden hamster

1965 • 68 citations

Culture of rat embryos with beta-D-xyloside: evidence of a role for proteoglycans in neurulation.

1982 • 68 citations

Neural tube development in mutant(curly tail)and normal mouse embryos: the timing of posterior neuropore closurein vivoandin vitro

1982 • 68 citations

Ethanol teratogenicity in mice: A light microscopic study

1982 • 68 citations

The embryology of trypan blue induced abnormalities in mice

1954 • 67 citations

Cephalic neurulation and optic vesicle formation in the early mouse embryo

1979 • 67 citations

Strain differences in the teratogenicity induced by sodium valproate in cultured mouse embryos

1988 • 66 citations

Effects of hyperthermia on rat embryos in culture

1975 • 66 citations

Distribution of surface coat material on fusing neural folds of mouse embryos during neurulation

1978 • 65 citations

Immunohistochemical localisation of chondroitin sulphate proteoglycans and the effects of chondroitinase ABC in 9- to 11-day rat embryos

1989 • 64 citations

Relationship between timing of posterior neuropore closure and development of spinal neural tube defects in mutant (curly tail) and normal mouse embryos in culture

1985 • 64 citations

Arsenic‐induced exencephaly in the mouse and associated lesions occurring during neurulation

1983 • 63 citations

Axial Elongation in the Mouse and its Retardation in Homozygous Looptail Mice

1962 • 61 citations

Accumulation of basement membrane-associated hyaluronate is reduced in the posterior neuropore region of mutant (curly tail) mouse embryos developing spinal neural tube defects

1988 • 61 citations

Arsenic-induced axial skeletal (dysraphic) disorders

1981 • 59 citations

The embryocidal and teratogenic effects of 5-bromodeoxyuridine in the pregnant hamster.

1965 • 58 citations

Prevention of spinal neural tube defects in the mouse embryo by growth retardation during neurulation

1988 • 57 citations

NEW SPLOTCH ALLELES IN THE MOUSE

1964 • 56 citations

The effect of excess vitamin A on the development of rat embryos in culture

1974 • 55 citations

DEVELOPMENT OF MICE HOMOZYGOUS FOR THE GENE FOR LOOPTAIL

1953 • 54 citations

Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro

1988 • 54 citations

Distribution of fibronectin, laminin and entactin in the environment of migrating neural crest cells in early mouse embryos.

1986 • 54 citations

Teratogenic effects of aliphatic nitriles

1981 • 53 citations

Regulation of the inducible heat shock 71 genes in early neural development of cultured rat embryos

1989 • 53 citations

The effects of Streptomyces hyaluronidase on tissue organization and cell cycle time in rat embryos

1986 • 53 citations

Development of neural tube basal lamina during neurulation and neural crest cell emigration in the trunk of the mouse embryo

1986 • 52 citations

Early changes in the mouse neuroepithelium preceding exencephaly induced by hypervitaminosis A

1978 • 52 citations

Teratogenic Interaction of Ethanol and Hyperthermia in Mice

1988 • 50 citations

Effect of acetaldehyde on the neuroepithelium of early mouse embryos.

1981 • 49 citations

Spinal ganglia reduction in the splotch‐delayed mouse neural tube defect mutant

1989 • 49 citations

A study of the pattern of prospective somites in the presomitic mesoderm of mouse embryos.

1986 • 48 citations

Brain cavitation and micrencephaly in lambs exposed to prenatal hyperthermia

1974 • 48 citations

Methylnitrosourea-Induced Malformations

1970 • 47 citations

Teratogenicity in vitro of 2‐acetylaminofluorene: Role of biotransformation in the rat

1983 • 47 citations

Proliferation in the neural tube of the splotch (Sp) mutant mouse

1974 • 46 citations

Synergistic teratogenic effects of arsenic and hyperthermia in hamsters

1977 • 45 citations

Ultrastructural alterations in neuroepithelial cells of mouse embryos exposed to cytotoxic doses of hydroxyurea

1977 • 44 citations

Generation of Anencephaly

1984 • 44 citations

Craniofacial and central nervous system malformations induced by triamcinolone acetonide in nonhuman primates: I. General teratogenicity

1980 • 43 citations

Genetic analysis of the cause of exencephaly in the SELH/Bc mouse stock

1989 • 40 citations

Studies on the mechanism of trypan blue teratogenicity in the rat developing in vivo and in vitro

1985 • 40 citations

A new crooked tail mutation involving distinctive pleiotropism

1954 • 40 citations

Toxicity of Copper Salts in Hamster Embryonic Development

1974 • 39 citations

Histological and ultrastructural studies on the origin of caudal neural crest cells in mouse embryos

1984 • 39 citations

A Note on Abnormalities induced in Mouse Embryos by Trypan Blue

1953 • 39 citations

Calcium and neurulation in mammalian embryos: II. Effects of cytoskeletal inhibitors and calcium antagonists on the neural folds of rat embryos

1986 • 38 citations

Analysis of metabolites of 2-acetylaminofluorene generated in an embryo culture system

1985 • 38 citations

Early morphological abnormalities in splotch mouse embryos and predisposition to gene‐ and retinoic acid‐induced neural tube defects

1983 • 38 citations

Congenital Malformations Induced by Laetrile

1982 • 37 citations

Absence of covalently linked core protein from newly synthesized hyaluronate

1982 • 37 citations

Heparitinase treatment of rat embryos during cranial neurulation

1989 • 35 citations

Distribution of fibronectin, laminin and entactin in the environment of migrating neural crest cells in early mouse embryos

1986 • 35 citations

Trypan blue induced teratogenesis of rat embryos cultivated in vitro

1966 • 35 citations

A mouse model for neural tube defects: The Curtailed (T^c) mutation produces spina bifida occulta in T^c/ + animals and spina bifida with meningomyelocele in T^c/t

1989 • 35 citations

Influence of Mitotic Activity on Neurulation Movements

1966 • 34 citations

Abnormal neural fold development in trisomy 12 and trisomy 14 mouse embryos

1981 • 34 citations

Extremes of Temperature

1977 • 34 citations

Changes in mesenchymal cell and hyaluronate distribution correlate with in vivo elevation of the mouse mesencephalic neural folds

1990 • 34 citations

The effects of 5‐bromodeoxyuridine on fusion of the cranial neural folds in the mouse embryo

1985 • 34 citations

Embryopathic Effects of 7,12-Dimethylbenz(a)anthracene and its Hydroxymethyl Derivatives in the Sprague–Dawley Rat

1970 • 33 citations

Neural tube closure defects following in vitro exposure of mouse embryos to xylocaine

1980 • 33 citations

Light microscopic studies on the pathogenesis of exencephaly and cranioschisis induced in the rat after neural tube closure

1988 • 33 citations

Gene‐teratogen interaction and its morphological basis in retinoic acid‐induced mouse spina bifida

1984 • 33 citations

Developmental anomalies induced by all‐trans‐retinoic acid in fetal mice: II. Induction of abnormal neuroepithelium

1987 • 33 citations

The mechanism of axial rotation in the rat embryo: an experimental study in vitro

1971 • 33 citations

Altered Electrolyte and Fluid Balance

1977 • 33 citations

Glycosaminoglycans vary in accumulation along the neuraxis during spinal neurulation in the mouse embryo

1988 • 33 citations

Gap junctional vesicles in the neural tube of the splotch (Sp) mutant mouse

1979 • 32 citations

A study on the pattern of prospective somites in the presomitic mesoderm of mouse embryos

1986 • 32 citations

The Transmission of Morphogenetic Signals from Amphibian Mesoderm to Ectoderm in Primary Induction

1976 • 31 citations

The influence of excess vitamin A on neural tube closure in the mouse embryo

1980 • 31 citations

Effect of hydroxyurea on neural tube defects in the curly-tail mouse.

1983 • 31 citations

Embryonic catch‐up growth after exposure to the ketone body D,L,‐beta‐hydroxybutyrate in vitro

1988 • 30 citations

Histological comparison of the effects of the splotch gene and retinoic acid on the closure of the mouse neural tube

1988 • 30 citations

Evidence for reopening of the cranial neural tube in mouse embryos treated with cadmium chloride

1985 • 30 citations

Reduction in the frequency of neural tube defects in splotch mice by retinoic acid

1985 • 30 citations

Experimental induction of cranioschisis aperta and exencephaly after neural tube closure

1984 • 29 citations

Modulation of the embryotoxicity and cytotoxicity elicited by 7-hydroxy-2-acetylaminofluorene and acetaminophen via deacetylation

1989 • 29 citations

Phospholipase C-induced neural tube defects in the mouse embryo

1980 • 28 citations

The cell surface coat in neurulating mouse and rat embryos, studied with lectins

1986 • 28 citations

Effect of mitomycin C on the neural tube defects of the curly‐tail mouse

1986 • 28 citations

A STRAIN DIFFERENCE IN RESPONSE TO THE TERATOGENIC EFFECT OF MATERNAL FASTING IN THE HOUSE MOUSE

1962 • 27 citations

Developmental toxicity of the cyanogenic glycoside linamarin in the golden hamster

1985 • 27 citations

The neural cell cycle in the looptail (Lp) mutant mouse

1974 • 27 citations

The teratogenic effects of dietary cassava on the pregnant albino rat: A preliminary report

1981 • 27 citations

Retinoic acid‐induced selective mortality of splotch‐delayed mouse neural tube defect mutants

1987 • 27 citations

The development of rib fusions, a mutation in the house mouse

1960 • 27 citations

D‐(–)‐beta‐hydroxybutyrate‐induced effects on mouse embryos in vitro

1987 • 26 citations

Dose-incidence Relationships for Exencephalia, Anophthalmia and Prenatal Mortality in Mouse Embryos Irradiated with Fission Neutrons or 250 kV X-rays

1987 • 26 citations

Differences in the toxicity and teratogenicity of cytochalasins D and E in various mouse strains

1982 • 25 citations

The interfrontal bone and mutant genes in the mouse.

1976 • 24 citations

Spina bifida : problems and management

1977 • 24 citations

Congenital deformities produced in hamsters by potato sprouts

1978 • 24 citations

The effects of cytochalasins on the ultrastructure of neurulating hamster embryos in vivo

1980 • 24 citations

Prevention of neural tube defects in curly‐tail mice by maternal administration of vitamin A

1982 • 23 citations

The relationship between emerging neural crest cells and basement membranes in the trunk of the mouse embryo: a TEM and immunocytochemical study

1986 • 23 citations

Interaction between the splotch mutation and retinoic acid in mouse neural tube defects in vitro

1988 • 23 citations

In vitro teratogenicity of ethylenethiourea in the rat

1987 • 22 citations

Pathogenesis of Neural Dysraphism in the Mouse Mutant Vacuolated Lens (vl)

1986 • 22 citations

Some additional observations relating to the mechanism of trypan blue induced teratogenesis

1975 • 22 citations

Lectin teratogenesis: Defects produced by Concanavalin a in fetal rabbits

1979 • 21 citations

Anomalies of neuroepithelial cell associations in the Splotch mutant embryo

1983 • 21 citations

Experiments and Ultrastructural Investigations on the Mouse Embryo during Early Teratogen-Sensitive Stages

1982 • 21 citations

A potential role for spectrin during neurulation

1986 • 20 citations

Trypan blue teratogenesis in the rat: Further observations in vitro

1982 • 20 citations

Teratogenic Effects of Trypan Blue on Hamster Embryos1

1958 • 20 citations

5-Azacytidine-induced exencephaly in mice.

1985 • 20 citations

Environmental heat stress effects in the hamster

1977 • 20 citations

Early development of the brain and spinal cord in dysraphic mice: A transmission electron microscopic study

1980 • 19 citations

The toxicity of niridazole in rat embryos in vitro

1986 • 19 citations

Morphogenesis of axial skeletal (dysraphic) disorders induced by aliphatic nitriles

1981 • 18 citations

Hyperthermia‐induced exencephaly in mice: Effect of multiple exposures

1988 • 18 citations

Studies of embryotoxic mechanisms of niridazole: Evidence that oxygen depletion plays a role in dysmorphogenicity

1989 • 18 citations

Time of teratogenic action of trypan blue in guinea pigs

1961 • 18 citations

Inheritance and morphology of exencephaly, a neonatal lethal recessive with partial penetrance, in the house mouse

1978 • 17 citations

Trypan blue accumulation in the embryonic gut of rats and mice during the teratogenic phase

1977 • 17 citations

The Embryoegnesis of Trypan‐blue Induced Spina Bifida Aperta and Short Tail in the Rat

1975 • 17 citations

The fine structure of ventricular cells in the brains of mouse embryos homozygous for the loop‐tail gene

1978 • 16 citations

Reconstitutive ability of axial tissue in early rat embryos after operations and culture in vitro

1975 • 16 citations

Surface defects in ventricular cells of brains of mouse embryos homozygous for the Loop‐tail gene: Scanning electron microscopic study

1975 • 16 citations

Fluorescence of trypan blue in frozen-dried embryos of the rat

1977 • 15 citations

Homeobox genes and development of the vertebrate CNS

1989 • 15 citations

Differential response of heterozygous curly‐tail mouse embryos to vitamin A teratogenesis depending on maternal genotype

1983 • 15 citations

Spina Bifida: Problems and Management

1977 • 15 citations

Abnormal neurol fold development in mouse trisomy 12 and trisomy 14. II. LM and TEM

1986 • 14 citations

Arachidonic acid reversal of phenytoin-induced neural tube and craniofacial defects in vitro in mice.

1988 • 14 citations

Hyperthermia and neural tube defects of the curly-tail mouse.

1987 • 14 citations

Die teratogene Wirkung von Äthylharnstoff und Nitrit bei Ratten

1971 • 13 citations

Enhancement of rifampin teratogenicity in cultured rat embryos

1983 • 13 citations

Incidence and potentiation of external and internal fetal anomalies resulting from chlordiazepoxide and amitriptyline alone and in combination

1984 • 13 citations

The effect of 5-bromodeoxyuridine on mouse embryos during neurulation in vitro

1984 • 12 citations

Trypan blue and the extra‐toes locus in the mouse

1970 • 11 citations

Closure of the posterior neuropore in the vl mutant mouse

1988 • 11 citations

Experimental teratological studies with the mouse CNS mutations cranioschisis and delayed splotch.

1985 • 10 citations

Influence of copper on the early post-implantation mouse embryo: An in vivo and in vitro study

1979 • 10 citations

Effect of the calmodulin inhibitor R24571 (calmidazolium) on rat embryos cultured in vitro

1984 • 9 citations

Ultrastructure of the Neural Basal Lamina in Loop-Tail Mice

1985 • 9 citations

Electron microscope observations of embryos from maternal rats treated with trypan blue

1979 • 9 citations

Teratogenicity of Di(2-ethylhexyl) Phthalate (DEHP) and Di-n-butyl Phthalate (DBP) in Mice

1982 • 8 citations

Methacrylic acid as a teratogen in rat embryo culture

1986 • 8 citations

An experimental study on the morphogenesis of spina bifida.

1981 • 8 citations

Histochemical analysis of the neural basal lamina in the hindbrain region of exencephalic mutant mice.

1985 • 8 citations

Craniomyeloschisis: A spontaneous mutation of the rat

1977 • 7 citations

The preventive influence of cysteamine on the terategenic action of 5-azacytidine

1978 • 7 citations

Chromosome Translocation (T(2;4)1 Sn)-Induced Neural Tube Defects in the Mouse Embryo

1983 • 6 citations

The induction of congenital abnormalities in mice by means of heterologous anti-mouse placenta serum

1970 • 6 citations

Morphometric analysis of the forebrain anomalies in the delayed Splotch mutant embryo.

1987 • 5 citations

Cytochemical Analysis of Neural Dysraphism in the vl Mutant Mouse

1988 • 5 citations

Induction of neural-tube defects in nonhuman primates.

1985 • 5 citations

Embryotoxic activity of hypoglycin-A in the rat

1968 • 4 citations

Evaluation of twelve chemicals in a preliminary developmental toxicity test

1988 • 4 citations

Somatomedin inhibitors from human serum produce abnormalities in mouse embryos in culture

1988 • 4 citations

THE MODE OF DEVELOPMENT OF AN INHERITED FORM OF ANENCEPHALY IN THE HOUSE MOUSE

1981 • 4 citations

Determination of folates in mouse plasma and embryo during organogenesis

1986 • 4 citations

Cysteine Interference with Chlorambucil-Induced Teratogenesis in the Rat

1972 • 4 citations