The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion.

1988 • 321 citations

Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.

1977 • 280 citations

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

1989 • 262 citations

Autocrine interaction between TGF alpha and the EGF-receptor: quantitative requirements for induction of the malignant phenotype.

1989 • 246 citations

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

1988 • 227 citations

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.

1988 • 226 citations

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

1988 • 226 citations

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.

1988 • 215 citations

Epidermal growth factor and its receptor

1987 • 197 citations

A v-erbB-related protooncogene, c-erb-B-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

1985 • 195 citations

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

1988 • 186 citations

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

1987 • 186 citations

Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.

1988 • 144 citations

Oncogenic Activation of p185^neu Stimulates Tyrosine Phosphorylation In Vivo

1988 • 142 citations

Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies

1985 • 124 citations

Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor.

1988 • 123 citations

Oncogenes and growth factors.

1988 • 117 citations

Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene.

1989 • 114 citations

Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis.

1988 • 103 citations

Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity.

1987 • 97 citations

SV40 T antigen induction and transformation in human fibroblast cell strains

1968 • 88 citations

Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions.

1988 • 81 citations

Phosphorylation process induced by epidermal growth factor alters the oncogenic and cellular neu (NGL) gene products.

1988 • 76 citations

Oncogenes and Growth Control

1986 • 71 citations

Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation.

1989 • 54 citations

Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors.

1989 • 53 citations

Role of Tyrosine Kinase and Membrane-Spanning Domains in Signal Transduction by the Platelet-Derived Growth Factor Receptor

1988 • 36 citations

The fms gene and the CSF-1 receptor.

1986 • 18 citations

A Mutant Epidermal Growth Factor Receptor with Defective Protein Tyrosine Kinase Is Unable To Stimulate Proto-Oncogene Expression and DNA Synthesis

1987 • 17 citations

Functional Heterogeneity of Proto-Oncogene Tyrosine Kinases: the C Terminus of the Human Epidermal Growth Factor Receptor Facilitates Cell Proliferation

1989 • 15 citations

The erbB gene and the EGF receptor.

1986 • 15 citations