The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gpl85^erbB-2 Determine the Specificity of Signal Transduction

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Murine Sarcoma and Leukemia Viruses: Assay Using Clonal Lines of Contact-Inhibited Mouse Cells

1969 • 821 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1989 • 342 citations

Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.

1977 • 280 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

1985 • 244 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.

1990 • 193 citations

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

1988 • 161 citations

Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.

1989 • 145 citations

EGF Receptor anderbB-2 Tyrosine Kinase Domains Confer Cell Specificity for Mitogenic Signaling

1990 • 142 citations

Oncogenic Activation of p185^neu Stimulates Tyrosine Phosphorylation In Vivo

1988 • 142 citations

Interaction between the epidermal growth factor receptor and phosphoinositide kinases.

1991 • 130 citations

Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies

1985 • 124 citations

Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation.

1990 • 113 citations

Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo.

1988 • 112 citations

Platelet-Derived Growth Factor Induces Rapid and Sustained Tyrosine Phosphorylation of Phospholipase C-γ in Quiescent BALB/c 3T3 Cells

1989 • 60 citations

The erbB-2 Mitogenic Signaling Pathway: Tyrosine Phosphorylation of Phospholipase C-γ and GTPase-Activating Protein Does Not Correlate with erbB-2 Mitogenic Potency

1991 • 21 citations

Different Structural Alterations Upregulate In Vitro Tyrosine Kinase Activity and Transforming Potency of the erbB-2 Gene

1988 • 7 citations