Regulatory conversation between antigen presenting cells and regulatory T cells enhance immune suppression

Dendritic cells and the control of immunity

1998 • 14,345 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

2002 • 1,296 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

2006 • 982 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo

2003 • 811 citations

Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization

2000 • 804 citations

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

2007 • 763 citations

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

2005 • 743 citations

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

2005 • 716 citations

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

2006 • 705 citations

Foxp3 in control of the regulatory T cell lineage

2007 • 690 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells

2004 • 629 citations

Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts

2006 • 625 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand

2007 • 614 citations

CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

2000 • 591 citations

Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells

2005 • 578 citations

The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments

2000 • 546 citations

Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes.

1997 • 524 citations

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

2003 • 516 citations

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

1999 • 499 citations

Activated CD4+CD25+ T cells selectively kill B lymphocytes

2006 • 484 citations

Expression of the integrin α_Eβ₇identifies unique subsets of CD25⁺as well as CD25⁻regulatory T cells

2002 • 476 citations

Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells

2004 • 472 citations

Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells

2004 • 459 citations

CD4+ and CD8+ anergic T cells induced by interleukin-10–treated human dendritic cells display antigen-specific suppressor activity

2002 • 455 citations

Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis

2004 • 420 citations

The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli

2000 • 412 citations

Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite

2005 • 406 citations

Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

2003 • 392 citations

Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25− into CD25+ T regulatory cells

2006 • 377 citations

The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance

2005 • 354 citations

Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

2007 • 312 citations

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

2007 • 311 citations

B Cell Regulation of CD4+CD25+ T Regulatory Cells and IL-10 Via B7 is Essential for Recovery From Experimental Autoimmune Encephalomyelitis

2007 • 305 citations

Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

2006 • 302 citations

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses

2004 • 282 citations

The Majority of Human Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells Bear Functional Skin-Homing Receptors

2006 • 278 citations

Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells

2006 • 277 citations

Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells

2005 • 273 citations

Interferon-β enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis

2004 • 269 citations

B7-H1 (Programmed Death-1 Ligand) on Dendritic Cells Is Involved in the Induction and Maintenance of T Cell Anergy

2003 • 263 citations

Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells

2003 • 257 citations

Functional expression of indoleamine 2,3-dioxygenase by murine CD8α+ dendritic cells

2002 • 251 citations

Inhibitory Feedback Loop Between Tolerogenic Dendritic Cells and Regulatory T Cells in Transplant Tolerance

2003 • 245 citations

Emerging Challenges in Regulatory T Cell Function and Biology

2007 • 245 citations

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses

2004 • 241 citations

CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis

2003 • 221 citations

CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25− T cells

2007 • 197 citations

Low-Dose Peptide Tolerance Therapy of Lupus Generates Plasmacytoid Dendritic Cells That Cause Expansion of Autoantigen-Specific Regulatory T Cells and Contraction of Inflammatory Th17 Cells

2007 • 194 citations

Toward the identification of a tolerogenic signature in IDO-competent dendritic cells

2005 • 184 citations

Development of thymic and splenic dendritic cell populations from different hemopoietic precursors

2001 • 180 citations

Kynurenine Pathway Enzymes in Dendritic Cells Initiate Tolerogenesis in the Absence of Functional IDO

2006 • 175 citations

Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse

2007 • 160 citations

Induction of organ‐selective CD4⁺ regulatory T cell homing

2007 • 158 citations

Tolerogenic dendritic cells and regulatory T cells: A two-way relationship

2007 • 155 citations

Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells

2005 • 148 citations

Distinctive role of CCR7 in migration and functional activity of naive‐ and effector/memory‐like Treg subsets

2007 • 147 citations

Human CD4+CD25+ Regulatory T Lymphocytes Inhibit Lipopolysaccharide-Induced Monocyte Survival through a Fas/Fas Ligand-Dependent Mechanism

2006 • 144 citations

CD4+CD25+ T Cells Lyse Antigen-Presenting B Cells by Fas-Fas Ligand Interaction in an Epitope-Specific Manner

2003 • 142 citations

A Crucial Role for Tryptophan Catabolism at the Host/Candida albicansInterface

2005 • 142 citations

CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3+ Regulatory and Th2 Effector Lymphocytes

2006 • 137 citations

Induction of anergic and regulatory T cells by plasmacytoid dendritic cells and other dendritic cell subsets

2002 • 134 citations

Induction of immunosuppressive functions of dendritic cells in vivo by CD4⁺CD25⁺ regulatory T cells: Role of B7‐H3 expression and antigen presentation

2007 • 129 citations

Modulation of Dendritic Cell Function by Naive and Regulatory CD4+ T Cells

2006 • 128 citations

Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue

2007 • 120 citations

Skin‐versus gut‐skewed homing receptor expression and intrinsic CCR4 expression on human peripheral blood CD4⁺CD25⁺ suppressor T cells

2003 • 112 citations

On the Edge of Autoimmunity

2005 • 104 citations

Liver-Derived DEC205+B220+CD19− Dendritic Cells Regulate T Cell Responses

2001 • 95 citations

Cutting Edge: Silencing Suppressor of Cytokine Signaling 3 Expression in Dendritic Cells Turns CD28-Ig from Immune Adjuvant to Suppressant

2005 • 91 citations

Interleukin-10-Treated Dendritic Cells Modulate Immune Responses of Naive and Sensitized T Cells In Vivo

2002 • 89 citations

Induction of tolerogenic DCs: ‘you are what you eat’

2003 • 86 citations

Cutting Edge: Primary B Lymphocytes Preferentially Expand Allogeneic FoxP3+ CD4 T Cells

2007 • 81 citations

CD4+CD25+ Regulatory T Cells Inhibit the Maturation but Not the Initiation of an Autoantibody Response

2005 • 78 citations

DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses

2000 • 65 citations

Monocyte-Derived Human Macrophages Mediate Anergy in Allogeneic T Cells and Induce Regulatory T Cells

2006 • 62 citations

Peripheral Tolerance Via the Anterior Chamber of the Eye: Role of B Cells in MHC Class I and II Antigen Presentation

2006 • 60 citations

CD25+CD4+ Regulatory T Cell Migration Requires L-Selectin Expression: L-Selectin Transcriptional Regulation Balances Constitutive Receptor Turnover

2007 • 56 citations

Alteration of the Migratory Behavior of UV-Induced Regulatory T Cells by Tissue-Specific Dendritic Cells

2007 • 48 citations

CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules

2007 • 43 citations

Soluble mouse B7-H3 down-regulates dendritic cell stimulatory capacity to allogenic T cell proliferation and production of IL-2 and IFN-gamma.

2006 • 25 citations

The Regulation of T Cell Responses by a Subpopulation of CD8+DEC205+ Murine Dendritic Cells

1997 • 11 citations