Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.

1990 • 763 citations

Cancer vaccines: between the idea and the reality

2003 • 616 citations

Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential

2002 • 374 citations

Tumor-Selective Induction of Apoptosis and the Small-Molecule Immune Response Modifier Imiquimod

2003 • 258 citations

Immunomodulatory and pharmacologic properties of imiquimod

2000 • 246 citations

Calculation of lytic units for the expression of cell-mediated cytotoxicity

1992 • 224 citations

Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice.

1996 • 207 citations

Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory.

1995 • 180 citations

Electroporated DNA Vaccine Clears Away Multifocal Mammary Carcinomas in Her-2/neuTransgenic Mice

2004 • 154 citations

Cancer immunotherapy: breaking the barriers to harvest the crop

2004 • 137 citations

Immune modulation and apoptosis induction: Two sides of the antitumoral activity of imiquimod

2004 • 110 citations

DNA vaccines encoding full-length or truncated Neu induce protective immunity against Neu-expressing mammary tumors.

1998 • 107 citations

Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery

2004 • 106 citations

LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice.

2003 • 89 citations

p185neu protein is required for tumor and anchorage-independent growth, not for cell proliferation of transgenic mammary carcinoma

2000 • 84 citations

HER-2/neu Oncogenic Protein: Issues in Vaccine Development

1998 • 80 citations

Cutting Edge: IL-10-Producing CD4+ T Cells Mediate Tumor Rejection

2002 • 80 citations

DNA vaccination against neu reduces breast cancer incidence and metastasis in mice

2001 • 70 citations

DNA vaccination with full-length or truncated Neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice

2000 • 70 citations

Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination

2001 • 67 citations

Cancer immunoprevention: tracking down persistent tumor antigens

2003 • 67 citations

Optimization of cytotoxic assay by target cell retention of the fluorescent dye carboxyfluorescein diacetate (CFDA) and comparison with conventional 51CR release assay

1992 • 61 citations

Vaccination against the HER-2/neu oncogenic protein.

2002 • 57 citations

Enhanced efficacy of DNA vaccination against Her‐2/neu tumor antigen by genetic adjuvants

2004 • 53 citations

Low effectiveness of DNA vaccination against HER-2/neu in ageing

2003 • 46 citations

Inhibition of mammary carcinogenesis by systemic interleukin 12 or p185neu DNA vaccination in Her-2/neu transgenic BALB/c mice.

2001 • 41 citations

Immunoprevention and immunotherapy of cancer in ageing

2004 • 40 citations

Imiquimod, a Toll-like receptor-7 agonist, induces perforin in cytotoxic T lymphocytes in vitro

2004 • 39 citations

Soluble Cytokines Can Act as Effective Adjuvants in Plasmid DNA Vaccines Targeting Self Tumor Antigens

2003 • 25 citations

Specific and nonspecific immunity in the prevention of spontaneous tumours

1999 • 21 citations