Imiquimod, a Toll-like receptor-7 agonist, induces perforin in cytotoxic T lymphocytes in vitro

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

2002 • 1,214 citations

Pattern Recognition Receptors

2002 • 1,139 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Self-administered Topical 5% Imiquimod Cream for External Anogenital Warts

1998 • 558 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod

2002 • 378 citations

Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential

2002 • 374 citations

Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: Results of a multicenter 6-week dose-response trial

2001 • 351 citations

Pathogenesis of atopic dermatitis

1999 • 297 citations

Modulation of TH1 and TH2 Cytokine Production with the Immune Response Modifiers, R-848 and Imiquimod

1999 • 259 citations

Immunomodulatory and pharmacologic properties of imiquimod

2000 • 246 citations

Self‐administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum

2000 • 238 citations

A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection

1999 • 227 citations

T-cell release of granulysin contributes to host defense in leprosy

2001 • 173 citations

Imiquimod, a Topical Immune Response Modifier, in the Treatment of Cutaneous Metastases of Malignant Melanoma

2002 • 157 citations

Perforin and Granzymes: Crucial Effector Molecules in Cytolytic T Lymphocyte and Natural Killer Cell-Mediated Cytotoxicity

1995 • 153 citations

Topical imiquimod treatment of a cutaneous melanomametastasis

2000 • 147 citations

Stimulation of Interferon and Cytokine Gene Expression by Imiquimod and Stimulation by Sendai Virus Utilize Similar Signal Transduction Pathways

1995 • 137 citations

Enhancement of the innate and cellular immune response in patients with genital warts treated with topical imiquimod cream 5%

1999 • 123 citations

A Role for NF-κB Activation in Perforin Expression of NK Cells Upon IL-2 Receptor Signaling

2002 • 98 citations

Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense.

1997 • 95 citations

The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-γ–producing cells

2003 • 88 citations

Safety and efficacy of imiquimod 5% cream in the treatment of penile genital warts in uncircumcised men when applied three times weekly or once per day

2001 • 81 citations

Role of a STAT Binding Site in the Regulation of the Human Perforin Promoter

1999 • 76 citations

Fas-Independent Cytotoxicity Mediated by Human CD4+ CTL Directed Against Herpes Simplex Virus-Infected Cells

1999 • 71 citations

Topical imiquimod to treat intraepidermal carcinoma.

2001 • 50 citations

Imiquimod: a potential role in dermatology?

2002 • 46 citations

New patient-applied therapy for anogenital warts is rated favourably by patients

2001 • 38 citations

Flow cytometric detection of perforin in normal human lymphocyte subpopulations defined by expression of activation/differentiation antigens

1998 • 28 citations

Perforin hyperreleasability and depletion in cytotoxic T cells from patients with exacerbated atopic dermatitis and asymptomatic rhinoconjunctivitis allergica

2001 • 26 citations

Perforin Granule Release from Cytotoxic Lymphocytes ex vivo Is Inhibited by Ciclosporin but Not by Methotrexate

2001 • 9 citations

Routine flow cytometric immuno‐staining of T‐cell perforin is preserved using diethylene glycol for erythrocyte‐lysis but lost by the use of ammonium chloride

2003 • 9 citations

Ausgedehnte aktinische Keratosen Vergleich einer topischen photodynamischen Therapie mit 5-Aminol�vulins�ure und topischer 5%iger Imiquimod-Creme

2001 • 8 citations

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