Immune modulation and apoptosis induction: Two sides of the antitumoral activity of imiquimod

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Proteases to die for

1998 • 1,241 citations

Induction of Apoptosis by Cancer Chemotherapy

2000 • 1,239 citations

Guidelines for the management of basal cell carcinoma

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Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

1999 • 829 citations

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

1996 • 756 citations

The Bax/Bcl-2 Ratio Determines the Susceptibility of Human Melanoma Cells to CD95/Fas-Mediated Apoptosis

2001 • 517 citations

XERODERMA PIGMENTOSUM: BIOCHEMICAL AND GENETIC CHARACTERISTICS

1975 • 406 citations

Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod

2002 • 378 citations

Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream

1999 • 375 citations

Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: Results of a multicenter 6-week dose-response trial

2001 • 351 citations

Guidelines for the management of basal cell carcinoma

1999 • 343 citations

SKIN CANCER AND IMMUNOSUPPRESSION

1971 • 303 citations

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

1997 • 302 citations

Imiquimod, a Topical Immune Response Modifier, Induces Migration of Langerhans Cells11The authors have declared a conflict of interest.

2000 • 295 citations

Cell surface Death Receptor signaling in normal and cancer cells

2003 • 286 citations

Modulation of TH1 and TH2 Cytokine Production with the Immune Response Modifiers, R-848 and Imiquimod

1999 • 259 citations

Tumor-Selective Induction of Apoptosis and the Small-Molecule Immune Response Modifier Imiquimod

2003 • 258 citations

TRAIL-induced signalling and apoptosis

2003 • 235 citations

Death receptors and melanoma resistance to apoptosis

2003 • 210 citations

Intralesional interferon therapy for basal cell carcinoma

1990 • 202 citations

UV‐B‐type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas

2002 • 195 citations

Death and decoy receptors and p53-mediated apoptosis

2000 • 192 citations

Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine.

1992 • 174 citations

Cytokine induction in mice by the immunomodulator imiquimod

1994 • 173 citations

Cytokine Induction in Hairless Mouse and Rat Skin After Topical Application of the Immune Response Modifiers Imiquimod and S-28463

1998 • 173 citations

Basal Cell Nevus Syndrome

1964 • 172 citations

Imiquimod, a Topical Immune Response Modifier, in the Treatment of Cutaneous Metastases of Malignant Melanoma

2002 • 157 citations

Topical imiquimod treatment of a cutaneous melanomametastasis

2000 • 147 citations

Cellular Requirements for Cytokine Production in Response to the Immunomodulators Imiquimod and S-27609

1995 • 140 citations

Successful treatment of actinic keratosis with imiquimod cream 5%: a report of six cases

2001 • 138 citations

Stimulation of Interferon and Cytokine Gene Expression by Imiquimod and Stimulation by Sendai Virus Utilize Similar Signal Transduction Pathways

1995 • 137 citations

The Imidazoquinolines, Imiquimod and R-848, Induce Functional, but Not Phenotypic, Maturation of Human Epidermal Langerhans' Cells

2000 • 133 citations

Death Receptor-Independent Apoptosis in Malignant Melanoma Induced by the Small-Molecule Immune Response Modifier Imiquimod

2004 • 127 citations

Immunomodulating and antiviral activities of the imidazoquinoline S-28463

1995 • 121 citations

Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual

1996 • 117 citations

The Use of Imiquimod 5% Cream for the Treatment of Superficial Basal Cell Carcinomas in a Basal Cell Nevus Syndrome Patient

2000 • 111 citations

Topically Applied Imiquimod Inhibits Vascular Tumor Growth In Vivo

2003 • 111 citations

Metastatic Basal Cell Carcinoma in Acquired Immunodeficiency Syndrome—Related Complex

1987 • 107 citations

Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs

1994 • 105 citations

Induction of Interferon and Other Cytokines by Imiquimod and Its Hydroxylated Metabolite R-842 in Human Blood Cells In Vitro

1994 • 105 citations

Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer

2003 • 104 citations

Application of a Topical Immune Response Modifier, Resiquimod Gel, to Modify the Recurrence Rate of Recurrent Genital Herpes: A Pilot Study

2001 • 99 citations

Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2.

2001 • 90 citations

The Complexity of TNF‐Related Apoptosis‐Inducing Ligand

2000 • 81 citations

Daily or Weekly Therapy with Resiquimod (R‐848) Reduces Genital Recurrences in Herpes Simplex Virus–Infected Guinea Pigs during and after Treatment

2001 • 79 citations

INDUCTION OF CYTOKINES IN CYNOMOLGUS MONKEYS BY THE IMMUNE RESPONSE MODIFIERS, IMIQUIMOD, S-27609 AND S-28463

1997 • 77 citations

The effect of intralesional interferon gamma on basal cell carcinomas

1990 • 58 citations

Basal cell carcinoma - new aspects of diagnosis and treatment

2000 • 57 citations

Effect of imiquimod as an adjuvant for immunotherapy of genital HSV in guinea-pigs

1995 • 48 citations

Imiquimod applied topically: A novel immune response modifier.

2001 • 44 citations

Evaluation of Superficial Basal Cell Carcinomas After Treatment With Imiquimod 5% Cream or Vehicle for Apoptosis and Lymphocyte Phenotyping

2003 • 43 citations

Expression of interferon-gamma receptors and interferon-gamma-induced up-regulation of intercellular adhesion molecule-1 in basal cell carcinoma; decreased expression of IFN-γR and shedding of ICAM-1 as a means to escape immune surveillance

1998 • 36 citations

Protracted cutaneous disorders in association with low CD4+ lymphocyte counts

1995 • 22 citations

Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor α and 1α,25-dihydroxyvitamin D 3

2000 • 18 citations

Multiple basal cell carcinomas associated with hairy cell leukaemia

1999 • 13 citations

Advances in the treatment of basal cell carcinoma: the promise of pharmacologic therapy.

2000 • 6 citations