Enhanced efficacy of DNA vaccination against Her‐2/neu tumor antigen by genetic adjuvants

Untangling the ErbB signalling network

2001 • 6,623 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

DNA Vaccines: Immunology, Application, and Optimization

2000 • 1,212 citations

Eta-1 (Osteopontin): An Early Component of Type-1 (Cell-Mediated) Immunity

2000 • 1,104 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

DNA VACCINES

1997 • 977 citations

THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

1999 • 712 citations

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer.

1994 • 467 citations

The intriguing role of polymorphonuclear neutrophils in antitumor reactions

2001 • 411 citations

In vivo generation of human dendritic cell subsets by Flt3 ligand

2000 • 397 citations

DNA Vaccination Against Rat Her-2/Neu p185 More Effectively Inhibits Carcinogenesis Than Transplantable Carcinomas in Transgenic BALB/c Mice

2000 • 354 citations

Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy

2000 • 349 citations

c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

1991 • 335 citations

Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.

1981 • 317 citations

Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo.

1991 • 315 citations

Flt3 ligand induces tumor regression and antitumor immune responses in vivo

1997 • 315 citations

Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines.

1997 • 307 citations

Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens.

1997 • 278 citations

Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways

2002 • 272 citations

IL-23 and IL-12 Have Overlapping, but Distinct, Effects on Murine Dendritic Cells

2002 • 240 citations

IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production

2001 • 237 citations

HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice.

2000 • 219 citations

Serological analysis of human tumor antigens: molecular definition and implications

1997 • 216 citations

Genetic adjuvants for DNA vaccines

2001 • 182 citations

Combination therapy with trastuzumab (Herceptin) and cisplatin for chemoresistant metastatic breast cancer: evidence for receptor-enhanced chemosensitivity.

1999 • 182 citations

Potent CD4+ T Cell Responses Elicited by a Bicistronic HIV-1 DNA Vaccine Expressing gp120 and GM-CSF

2002 • 163 citations

Peptides derived from a wild-type murine proto-oncogene c-erbB-2/HER2/neu can induce CTL and tumor suppression in syngeneic hosts.

1997 • 157 citations

The Timing of GM-CSF Expression Plasmid Administration Influences the Th1/Th2 Response Induced by an HIV-1-Specific DNA Vaccine

2000 • 140 citations

An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4.

1994 • 130 citations

Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas

2003 • 123 citations

Purification of a factor which provides a costimulatory signal for gamma interferon production

1993 • 118 citations

Plasmid Vaccine Expressing Granulocyte-Macrophage Colony-Stimulating Factor Attracts Infiltrates Including Immature Dendritic Cells into Injected Muscles

2000 • 110 citations

Protection against mammary tumor growth by vaccination with full-length, modified humanErbB-2 DNA

1999 • 110 citations

DNA vaccines encoding full-length or truncated Neu induce protective immunity against Neu-expressing mammary tumors.

1998 • 107 citations

Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations augmented with cytokine-expressing plasmids.

1997 • 103 citations

Cytokine Molecular Adjuvants Modulate Immune Responses Induced by DNA Vaccine Constructs for HIV-1 and SIV

1999 • 99 citations

Preclinical studies with Fc(gamma)R bispecific antibodies and granulocyte colony-stimulating factor-primed neutrophils as effector cells against HER-2/neu overexpressing breast cancer.

1997 • 97 citations

Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance.

1990 • 91 citations

Optimal Induction of Hepatitis C Virus Envelope-Specific Immunity by Bicistronic Plasmid DNA Inoculation with the Granulocyte-Macrophage Colony-Stimulating Factor Gene

1998 • 82 citations

Cutting Edge: CD8+ Effector T Cells Reject Tumors by Direct Antigen Recognition but Indirect Action on Host Cells

2003 • 78 citations

Complementary Antitumor Immunity Induced by Plasmid DNA Encoding Secreted and Cytoplasmic Human ErbB-2

2001 • 76 citations

Murine Flt3 Ligand Expands Distinct Dendritic Cells with Both Tolerogenic and Immunogenic Properties

2003 • 68 citations

Immunogene Therapy of Tumors with Vaccine Based on Xenogeneic Epidermal Growth Factor Receptor

2003 • 67 citations

Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination

2001 • 67 citations

Co-expression of granulocyte-macrophage colony-stimulating factor with antigen enhances humoral and tumor immunity after DNA vaccination

2002 • 64 citations

Induction of Antigen-Specific Tumor Immunity by Genetic and Cellular Vaccines against MAGE: Enhanced Tumor Protection by Coexpression of Granulocyte-Macrophage Colony-Stimulating Factor and B7-1

1996 • 64 citations

DNA-Encoded Fetal Liver Tyrosine Kinase 3 Ligand and Granulocyte Macrophage-Colony-Stimulating Factor Increase Dendritic Cell Recruitment to the Inoculation Site and Enhance Antigen-Specific CD4+ T Cell Responses Induced by DNA Vaccination of Outbred Animals

2002 • 61 citations

Improved Expression of Vascular Endothelial Growth Factor by Naked DNA in Mouse Skeletal Muscles: Implication for Gene Therapy of Ischemic Diseases

2000 • 52 citations

In vivo properties of three human HER2/neu-expressing murine cell lines in immunocompetent mice.

1999 • 49 citations

COSTIMULATION BLOCKADE PROMOTES THE APOPTOTIC DEATH OF GRAFT-INFILTRATING T CELLS AND PROLONGS SURVIVAL OF HEPATIC ALLOGRAFTS FROM FLT3L-TREATED DONORS1

2001 • 42 citations

Identification of a Domain Containing B-Cell Epitopes in Hepatitis C Virus E2 Glycoprotein by Using Mouse Monoclonal Antibodies

1999 • 29 citations

Trafficking of APC from liver allografts of Flt3L-treated donors: augmentation of potent allostimulatory cells in recipient lymphoid tissue is associated with a switch from tolerance to rejection

1999 • 25 citations

A Family of Compact Plasmid Vectors for DNA Immunization in Humans

2000 • 25 citations

Both the epitope specificity and isotype are important in the antitumor effect of monoclonal antibodies against Her‐2/neu antigen

2002 • 22 citations

Comparative analysis of effects of cytokine gene adjuvants on DNA vaccination against Mycobacterium tuberculosis heat shock protein 65

2003 • 22 citations

Comparison of the antitumor efficacies of Her-2/neu DNA vaccines inducing contrasting IgG immunity but comparable CTL activity in mice

2003 • 14 citations