Immunoprevention and immunotherapy of cancer in ageing

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

Phylogenetic Perspectives in Innate Immunity

1999 • 2,478 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

2002 • 1,343 citations

The Aging Immune System: Primer and Prospectus

1996 • 1,166 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.

1990 • 763 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands

1994 • 685 citations

Prospective Randomized Trial of High-Dose Interleukin-2 Alone or in Conjunction With Lymphokine-Activated Killer Cells for the Treatment of Patients With Advanced Cancer

1993 • 639 citations

Cancer vaccines: between the idea and the reality

2003 • 616 citations

Effectiveness of Pneumococcal Polysaccharide Vaccine in Older Adults

2003 • 612 citations

Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging

2002 • 609 citations

Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines.

1995 • 542 citations

Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

2000 • 515 citations

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer.

1994 • 467 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians [see comments]

1993 • 443 citations

Generation of T-Cell Immunity to the HER-2/neu Protein After Active Immunization With HER-2/neu Peptide–Based Vaccines

2002 • 426 citations

Altered cytokine production in the elderly

1998 • 379 citations

Thymic involution with ageing: obsolescence or good housekeeping?

1996 • 351 citations

High-titer HER-2/neu protein-specific antibody can be detected in patients with early-stage breast cancer.

1997 • 347 citations

Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back.

1997 • 342 citations

The Cellular and Subcellular Bases of Immunosenescence

1989 • 326 citations

Impairment of proteasome structure and function in aging

2002 • 295 citations

NK phenotypic markers and IL2 response in NK cells from elderly people

1999 • 275 citations

The Decline in B Lymphopoiesis in Aged Mice Reflects Loss of Very Early B-Lineage Precursors

2003 • 250 citations

Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?

1994 • 245 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.

2002 • 214 citations

Effect of age on hematopoiesis in man

1984 • 192 citations

Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene.

1992 • 185 citations

Discussion

1997 • 175 citations

Antitumor Efficacy of Adenocarcinoma Cells Engineered to Produce Interleukin 12 (IL-12) or Other Cytokines Compared With Exogenous IL-12

1997 • 174 citations

Quantitative intracellular cytokine measurement: age-related changes in proinflammatory cytokine production

1998 • 174 citations

Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep

1995 • 170 citations

Impact of aging on innate immunity

1998 • 163 citations

Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells

2000 • 163 citations

Immunosenescence

1997 • 156 citations

Aging and Cancer: Issues of Basic and Clinical Science

1997 • 149 citations

IFN-γ–dependent transcription of MHC class II IA is impaired in macrophages from aged mice

2001 • 148 citations

Polymorphonuclear Functions and Aging in Humans*

1981 • 143 citations

Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70.

1979 • 139 citations

Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals

1996 • 137 citations

Phenotypic and functional characteristics of circulating monocytes of elderly persons☆

1999 • 137 citations

Altered Angiogenesis Underlying Age-Dependent Changes in Tumor Growth

1994 • 136 citations

Altered T cell signalling in ageing

2001 • 133 citations

Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial

1999 • 131 citations

Hematopoietic Progenitors and Aging: Alterations in Granulocytic Precursors and Responsiveness to Recombinant Human G-CSF, GM-CSF, and IL-3

1993 • 129 citations

Phagocytosis and development: back to the future

1999 • 125 citations

Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas

2003 • 123 citations

Defective generation but normal maintenance of memory T cells in old mice

2002 • 122 citations

Natural killer cells in healthy aging

1999 • 116 citations

Activation of C-C beta-chemokines in human peripheral blood gammadelta T cells by isopentenyl pyrophosphate and regulation by cytokines.

2000 • 115 citations

Immunogenicity of combined hepatitis A and B vaccine in elderly persons

2003 • 114 citations

Non-specific immunity in aging: Deficiency of monocyte and polymorphonuclear cell-mediated functions

1984 • 105 citations

Host Defenses in the Aged: Evaluation of Components of the Inflammatory and Immune Responses

1978 • 103 citations

Decreased natural killer cell activity is associated with atherosclerosis in elderly humans

2001 • 102 citations

Antitumoral properties of aged human monocytes.

1995 • 100 citations

Age-dependent alterations of Fc gamma receptor-mediated effector functions of human polymorphonuclear leucocytes.

1985 • 99 citations

Neutrophil Function in Healthy Elderly Subjects

1990 • 99 citations

Mucin 1-specific immunotherapy in a mouse model of spontaneous breast cancer.

2003 • 90 citations

Numerical and functional alterations of circulating gammadelta T lymphocytes in aged people and centenarians.

2002 • 89 citations

Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents

1997 • 88 citations

Activation of C-C β-chemokines in human peripheral blood γδ T cells by isopentenyl pyrophosphate and regulation by cytokines

2000 • 88 citations

Numerical and functional alterations of circulating γδ T lymphocytes in aged people and centenarians

2002 • 85 citations

Plasticity of neuroendocrine-thymus interactions during aging

1997 • 84 citations

Immunoproteasomes and immunosenescence

2003 • 84 citations

Effect of zinc or zinc plus arginine supplementation on antibody titre and lymphocyte subsets after influenza vaccination in elderly subjects: a randomized controlled trial

1998 • 81 citations

Influenza and aging: Age-related changes and the effects of thymosin on the antibody response to influenza vaccine

1984 • 81 citations

Cytokine production by stimulated mononuclear cells did not change with aging in apparently healthy, well-nourished women

2001 • 79 citations

Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1β converting enzyme cDNA

1999 • 76 citations

Senescence and cytokines modulate the NK cell expression

1997 • 75 citations

Interleukin-2 production and activity in aged humans

1985 • 73 citations

Molecular and cellular basis of immunosenescence

1998 • 72 citations

DNA vaccination with full-length or truncated Neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice

2000 • 70 citations

The role of calcium in the age-related decline of neutrophil function

1988 • 69 citations

Different IL-8 production by T and NK lymphocytes in elderly subjects

2001 • 69 citations

Cancer immunoprevention: tracking down persistent tumor antigens

2003 • 67 citations

Effect of Host Age on Tumor-Associated Angiogenesis in Mice

1990 • 66 citations

Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice

2000 • 66 citations

Vaccination with Allogeneic Dendritic Cells Fused to Carcinoma Cells Induces Antitumor Immunity in MUC1 Transgenic Mice

2001 • 65 citations

Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age

2002 • 64 citations

Age-related differences in granulocyte Chemotaxis and degranulation

1986 • 60 citations

Gamma/delta T lymphocytes are affected in the elderly

2002 • 60 citations

The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis

1984 • 58 citations

Vaccination against the HER-2/neu oncogenic protein.

2002 • 57 citations

Clonal expansions of Vδ1⁺ and Vδ2⁺ cells increase with age and limit the repertoire of human γδ T cells

1994 • 55 citations

Innate T-cell immunity to nonpeptidic antigens

1998 • 54 citations

Reduced Number and Impaired Function of Circulating γδ T Cells in Patients with Cutaneous Primary Melanoma

2003 • 52 citations

Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples

1996 • 51 citations

Age-related decrease in frequencies of B-cell precursors and specific helper T cells involved in the IgG anti-tetanus toxoid antibody production in humans

1982 • 50 citations

Effect of aging on the tumoricidal functions of murine peritoneal macrophages.

1996 • 50 citations

Recovery of spleen cell natural killer activity by thyroid hormone treatment in old mice.

1991 • 49 citations

Decreases in macrophage mediated antitumor activity with aging

1995 • 48 citations

Low effectiveness of DNA vaccination against HER-2/neu in ageing

2003 • 46 citations

The Importance of Immunesenescence in the Incidence and Malignant Properties of Cancer in Hosts of Advanced Age

1989 • 45 citations

Interleukin-2-induced activation of natural killer activity in spleen cells from old and young mice.

1984 • 44 citations

Clinical studies of vaccines targeting breast cancer.

2003 • 44 citations

Interleukin-12 release by mitogen-stimulated mononuclear cells in the elderly

1998 • 44 citations

B Cells of Aged Mice Show Decreased Expansion in Response to Antigen, But Are Normal in Effector Function

2001 • 41 citations

Regulation of cytokine production in aging: use of recombinant cytokines to upregulate mitogen-stimulated spleen cells

1997 • 41 citations

Enhancement by interferon of natural cytotoxic activities of lymphocytes from human cord blood and peripheral blood of aged persons

1979 • 40 citations

Adjuvant effect of low-dose interleukin-2 on antibody response to influenza virus vaccination in healthy elderly subjects

1994 • 39 citations

T Cell Subset Patterns That Predict Resistance to Spontaneous Lymphoma, Mammary Adenocarcinoma, and Fibrosarcoma in Mice

2002 • 38 citations

Increased production of TGF-beta and Il-6 by aged spleen cells

1993 • 35 citations

Decline in natural killer cell-mediated immunosurveillance in aging mice — a consequence of reduced cell production and tumor binding capacity

1994 • 35 citations

Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas

2003 • 26 citations

Clearance of foreign red cells from the blood of aging mice

1973 • 25 citations

Immunological studies in human ageing. I. In vitro functions of T cells and polymorphs.

1981 • 23 citations

Phenotypic expression of natural killer cell associated membrane antigens and cytolytic function of peripheral blood cells from different aged humans.

1986 • 23 citations

Age-dependent macrophage functions in New Zealand Black mice

1979 • 22 citations

Intravenous interleukin-2 in patients over 65 with metastatic renal carcinoma

1992 • 21 citations

Long-term melatonin supplementation does not recover the impairment of natural killer cell activity and lymphocyte proliferation in aging mice

1997 • 21 citations

Selection of metastatic tumour phenotypes by host immune systems

1999 • 19 citations

Lymphokine-activated killer cells and aging in mice: Significance for defining the precursor cell

1987 • 18 citations

Improvement of natural killer cell activity by in vitro active lipids (AL 721) administration in old mice

1990 • 17 citations

Lymphokine-activated killer (LAK) cells: I. Age-dependent decline of LAK cell-mediated cytotoxicity

1987 • 16 citations

Evaluation of lymphokine-activated killer cell development in young and old healthy humans.

1995 • 15 citations

Role of Pituitary-Thyroid Axis on Basal and Lymphokine-Induced NK Cell Activity in Aging

1990 • 15 citations

Lymphokine-activated killer cells derived from murine bone marrow: Age-associated difference in precursor cell populations demonstrated by response to interferon

1988 • 14 citations

GENERATION OF HUMAN LYMPHOKINE-ACTIVATED KILLER CELLS FOLLOWING AN IL-2 PULSE IN ELDERLY CANCER PATIENTS

1998 • 13 citations

Effects of age on neutrophil function and its relevance to bacterial infections in the elderly.

1997 • 12 citations

Effectiveness of Immunotherapy in Aged Leukemic Mice

1995 • 12 citations

Effect of IL-2 in vitro on CTL generation in spleen cells of young and old mice: Asialo GM1+ cells are required for the apparent restoration of the CTL response

1989 • 12 citations

Induction of natural killer cell activity and perforin and granzyme B gene expression following continuous culture of short pulse with interleukin-12 in young and old mice.

2000 • 11 citations

Down-regulation of LAK cell-mediated cytotoxicity: cancer and ageing

1990 • 8 citations

Plasticity of neuroendocrine-immune interactions during aging.

1991 • 7 citations

Reversibility of age associated NK defect by endocrinological and/or nutritional intervention.

1991 • 6 citations

Plasticity of Neuroendocrine-Immune Interactions During Aging

1994 • 4 citations

MHC-Unrestricted Cytotoxicity in Ageing

2004 • 2 citations