Tumor-Selective Induction of Apoptosis and the Small-Molecule Immune Response Modifier Imiquimod

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

Textbook of dermatology

1968 • 1,648 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Apoptosis control by death and decoy receptors

1999 • 1,296 citations

Proteases to die for

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Induction of Apoptosis by Cancer Chemotherapy

2000 • 1,239 citations

Dysregulation of Apoptosis in Cancer

1999 • 983 citations

Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

1999 • 829 citations

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

1996 • 756 citations

Squamous cell carcinoma

1996 • 606 citations

Nonmelanoma Cancers of the Skin

1992 • 541 citations

The Bax/Bcl-2 Ratio Determines the Susceptibility of Human Melanoma Cells to CD95/Fas-Mediated Apoptosis

2001 • 517 citations

XERODERMA PIGMENTOSUM: BIOCHEMICAL AND GENETIC CHARACTERISTICS

1975 • 406 citations

Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream

1999 • 375 citations

Incidence of non-melanocytic skin cancer treated in Australia

1988 • 360 citations

Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: Results of a multicenter 6-week dose-response trial

2001 • 351 citations

SKIN CANCER AND IMMUNOSUPPRESSION

1971 • 303 citations

Imiquimod, a Topical Immune Response Modifier, Induces Migration of Langerhans Cells11The authors have declared a conflict of interest.

2000 • 295 citations

Trends in basal cell carcinoma, squamous cell carcinoma, and melanoma of the skin from 1973 through 1987

1990 • 281 citations

Modulation of TH1 and TH2 Cytokine Production with the Immune Response Modifiers, R-848 and Imiquimod

1999 • 259 citations

Cytotoxic drugs and the CD95 pathway

1999 • 212 citations

UV‐B‐type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas

2002 • 195 citations

Death and decoy receptors and p53-mediated apoptosis

2000 • 192 citations

Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine.

1992 • 174 citations

Cytokine induction in mice by the immunomodulator imiquimod

1994 • 173 citations

Cytokine Induction in Hairless Mouse and Rat Skin After Topical Application of the Immune Response Modifiers Imiquimod and S-28463

1998 • 173 citations

Imiquimod, a Topical Immune Response Modifier, in the Treatment of Cutaneous Metastases of Malignant Melanoma

2002 • 157 citations

Cellular Requirements for Cytokine Production in Response to the Immunomodulators Imiquimod and S-27609

1995 • 140 citations

Successful treatment of actinic keratosis with imiquimod cream 5%: a report of six cases

2001 • 138 citations

Stimulation of Interferon and Cytokine Gene Expression by Imiquimod and Stimulation by Sendai Virus Utilize Similar Signal Transduction Pathways

1995 • 137 citations

The Imidazoquinolines, Imiquimod and R-848, Induce Functional, but Not Phenotypic, Maturation of Human Epidermal Langerhans' Cells

2000 • 133 citations

Immunomodulating and antiviral activities of the imidazoquinoline S-28463

1995 • 121 citations

Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual

1996 • 117 citations

Basal cell carcinoma

1996 • 111 citations

Metastatic Basal Cell Carcinoma in Acquired Immunodeficiency Syndrome—Related Complex

1987 • 107 citations

Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs

1994 • 105 citations

Induction of Interferon and Other Cytokines by Imiquimod and Its Hydroxylated Metabolite R-842 in Human Blood Cells In Vitro

1994 • 105 citations

Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2.

2001 • 90 citations

The Complexity of TNF‐Related Apoptosis‐Inducing Ligand

2000 • 81 citations

INDUCTION OF CYTOKINES IN CYNOMOLGUS MONKEYS BY THE IMMUNE RESPONSE MODIFIERS, IMIQUIMOD, S-27609 AND S-28463

1997 • 77 citations

Human sweat gland myoepithelial cells express a unique set of cytokeratins and reveal the potential for alternative epithelial and mesenchymal differentiation states in culture

1999 • 67 citations

Nnmelanotic Skin Cancer and Solar Keratoses

1987 • 62 citations

The effect of intralesional interferon gamma on basal cell carcinomas

1990 • 58 citations

Effect of imiquimod as an adjuvant for immunotherapy of genital HSV in guinea-pigs

1995 • 48 citations

Imiquimod applied topically: A novel immune response modifier.

2001 • 44 citations

Basal-Cell Adhesion Molecule (B-CAM) is Induced in Epithelial Skin Tumors and Inflammatory Epidermis, and is Expressed at Cell–Cell and Cell–Substrate Contact Sites

2000 • 42 citations

Expression of interferon-gamma receptors and interferon-gamma-induced up-regulation of intercellular adhesion molecule-1 in basal cell carcinoma; decreased expression of IFN-γR and shedding of ICAM-1 as a means to escape immune surveillance

1998 • 36 citations

Aminolevulinic acid (Levulan) in photodynamic therapy of actinic keratoses.

2001 • 33 citations

Protracted cutaneous disorders in association with low CD4+ lymphocyte counts

1995 • 22 citations

Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor α and 1α,25-dihydroxyvitamin D 3

2000 • 18 citations

True

1999 • 8 citations