Soluble Cytokines Can Act as Effective Adjuvants in Plasmid DNA Vaccines Targeting Self Tumor Antigens

DNA Vaccines: Immunology, Application, and Optimization

2000 • 1,212 citations

DNA VACCINES

1997 • 977 citations

Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses.

1994 • 550 citations

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.

1996 • 524 citations

Gene vaccination with naked plasmid DNA: mechanism of CTL priming.

1996 • 494 citations

Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

1995 • 486 citations

Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients

2001 • 436 citations

Direct Gene Transfer into Skeletal MuscleIn Vivo: Factors Affecting Efficiency of Transfer and Stability of Expression

1993 • 380 citations

In vivo engineering of a cellular immune response by co-administration of IL-12 expression vector with a DNA immunogen

1997 • 347 citations

Immunoselection in vivo: Independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma

1997 • 311 citations

Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines

1996 • 308 citations

In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen.

1997 • 286 citations

The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites.

1997 • 257 citations

Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines

1996 • 256 citations

DNA vaccination: antigen presentation and the induction of immunity

2000 • 255 citations

Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2

1997 • 237 citations

Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunity.

2002 • 233 citations

Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes

1997 • 226 citations

Immunization with a peptide epitope (p369-377) from HER-2/neu leads to peptide-specific cytotoxic T lymphocytes that fail to recognize HER-2/neu+ tumors.

1998 • 220 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

In Vivo Priming by DNA Injection Occurs Predominantly by Antigen Transfer

1999 • 180 citations

DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost

1996 • 161 citations

Adjuvant Effect of IL-12: Conversion of Peptide Antigen Administration from Tolerizing to Immunizing for CD8+ T Cells In Vivo

1999 • 138 citations

Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.

1997 • 132 citations

Cutting Edge: Differentiation of Antitumor CTL In Vivo Requires Host Expression of Stat1

1999 • 103 citations

T Helper Differentiation Proceeds Through Stat1-Dependent, Stat4-Dependent and Stat4-Independent Phases

1999 • 81 citations

Feline Leukemia Virus DNA Vaccine Efficacy Is Enhanced by Coadministration with Interleukin-12 (IL-12) and IL-18 Expression Vectors

2001 • 68 citations

Human HER‐2/neu protein immunization circumvents tolerance to rat neu: a vaccine strategy for ‘self’ tumour antigens

1998 • 55 citations

The immune system as anti-tumor sentinel: molecular requirements for an anti-tumor immune response.

1999 • 50 citations

Macrophage Colony-Stimulating Factor Can Modulate Immune Responses and Attract Dendritic Cells in Vivo

2000 • 46 citations

Induction of long-lasting cytokine effect by injection of IL-12 encoding plasmid DNA

2000 • 30 citations

Cell-Mediated DNA Transport Between Distant Inflammatory Sites Following Intradermal DNA Immunization in the Presence of Adjuvant

2000 • 28 citations

Antigen loss variants of a murine renal cell carcinoma: Implications for tumor vaccination

1998 • 18 citations

Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production

2000 • 18 citations

The next wave of recombinant and synthetic anticancer vaccines

1995 • 16 citations

Antigen-specific recall urticaria to a peptide-based vaccine☆☆☆★★★

1999 • 16 citations

Molecular Mechanisms Involved in the Migration of Epidermal Dendritic Cells in the Skin

1999 • 9 citations