Eukaryotic translation initiation factors and regulators

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 • 2,096 citations

Circularization of mRNA by Eukaryotic Translation Initiation Factors

1998 • 940 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP

1997 • 660 citations

A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation

1998 • 560 citations

Recognition of Polyadenylate RNA by the Poly(A)-Binding Protein

1999 • 494 citations

Cap-Dependent Translation Initiation in Eukaryotes Is Regulated by a Molecular Mimic of eIF4G

1999 • 490 citations

Crystal Structure of an Initiation Factor Bound to the 30 S Ribosomal Subunit

2001 • 373 citations

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

1998 • 369 citations

Biophysical Studies of eIF4E Cap-binding Protein: Recognition of mRNA 5′ Cap Structure and Synthetic Fragments of eIF4G and 4E-BP1 Proteins

2002 • 366 citations

Structure of translation factor elF4E bound to m7GDP and interaction with 4E-binding protein

1997 • 365 citations

Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F

1998 • 338 citations

Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation

2001 • 328 citations

Does phosphorylation of the cap‐binding protein eIF4E play a role in translation initiation?

2002 • 296 citations

Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase

2000 • 291 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

The Eukaryotic Polypeptide Chain Releasing Factor (eRF3/GSPT) Carrying the Translation Termination Signal to the 3′-Poly(A) Tail of mRNA

1999 • 252 citations

Phosphorylation of Eukaryotic Initiation Factor 4E Markedly Reduces Its Affinity for Capped mRNA

2002 • 252 citations

X-Ray Structures of the Universal Translation Initiation Factor IF2/eIF5B

2000 • 238 citations

A Novel Role of the Mammalian GSPT/eRF3 Associating with Poly(A)-binding Protein in Cap/Poly(A)-dependent Translation

2002 • 217 citations

A Conserved HEAT Domain within eIF4G Directs Assembly of the Translation Initiation Machinery

2001 • 213 citations

Translational Repression by a Novel Partner of Human Poly(A) Binding Protein, Paip2

2001 • 209 citations

Structure and function of the C-terminal PABC domain of human poly(A)-binding protein

2001 • 199 citations

The mRNA Closed-loop Model: The Function of PABP and PABP-interacting Proteins in mRNA Translation

2001 • 178 citations

Phosphorylation of Eukaryotic Translation Initiation Factor 4E Is Critical for Growth

2002 • 175 citations

The eIF1A Solution Structure Reveals a Large RNA-Binding Surface Important for Scanning Function

2000 • 172 citations

X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix.

1995 • 160 citations

Structure and interactions of the translation initiation factor eIF1

1999 • 159 citations

Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein

2001 • 156 citations

The structure of the translational initiation factor IF1 from E.coli contains an oligomer-binding motif

1997 • 151 citations

Paip1 Interacts with Poly(A) Binding Protein through Two Independent Binding Motifs

2002 • 141 citations

Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo

2003 • 140 citations

Eukaryotic translation initiation: there are (at least) two sides to every story.

2000 • 138 citations

Recognition of eIF4G by Rotavirus NSP3 Reveals a Basis for mRNA Circularization

2002 • 135 citations

Phosphorylation of eIF4E attenuates its interaction with mRNA 5′ cap analogs by electrostatic repulsion: Intein-mediated protein ligation strategy to obtain phosphorylated protein

2003 • 129 citations

Uncoupling of Initiation Factor eIF5B/IF2 GTPase and Translational Activities by Mutations that Lower Ribosome Affinity

2002 • 122 citations

Crystal structures of eukaryotic translation initiation factor 5A fromMethanococcus jannaschiiat 1.8 Å resolution

1998 • 121 citations

Crystal structures of 7-methylguanosine 5′-triphosphate (m7GTP)- and P1-7-methylguanosine-P3-adenosine-5′,5′-triphosphate (m7GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region

2002 • 115 citations

The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors

2002 • 104 citations

X-Ray Crystal Structure and Functional Analysis of Vaccinia Virus K3L Reveals Molecular Determinants for PKR Subversion and Substrate Recognition

2002 • 104 citations

Recognition of the Rotavirus mRNA 3′ Consensus by an Asymmetric NSP3 Homodimer

2002 • 103 citations

Disruption of the Interaction of Mammalian Protein Synthesis Eukaryotic Initiation Factor 4B with the Poly(A)-binding Protein by Caspase- and Viral Protease-mediated Cleavages

2001 • 100 citations

Structure and Function of Bacterial Initiation Factors

2002 • 90 citations

The Cap-binding Protein eIF4E Promotes Folding of a Functional Domain of Yeast Translation Initiation Factor eIF4G1

1999 • 90 citations

Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners

2003 • 87 citations

X-ray structure of the human hyperplastic discs protein: An ortholog of the C-terminal domain of poly(A)-binding protein

2001 • 84 citations

Crystal structures of ribosome anti-association factor IF6.

2000 • 74 citations

Engaging the ribosome: universal IFs of translation

2001 • 73 citations

Solution Structure of the Ribosome-binding Domain ofE. coliTranslation Initiation Factor IF3. Homology with the U1A Protein of the Eukaryotic Spliceosome

1995 • 68 citations

Structure of the fMet-tRNAfMet-binding domain of B.stearothermophilus initiation factor IF2

2000 • 65 citations

Crystal Structure of the N-terminal Segment of Human Eukaryotic Translation Initiation Factor 2α

2002 • 65 citations

Myxoma Virus Immunomodulatory Protein M156R is a Structural Mimic of Eukaryotic Translation Initiation Factor eIF2α

2002 • 50 citations

Translation initiation at non-AUG codons mediated by weakened association of eukaryotic initiation factor (eIF) 2 subunits

2002 • 50 citations

1H and 15N Resonance Assignments and Structure of the N-Terminal Domain of Escherichia coli Initiation Factor 3

1995 • 45 citations

A phylogenetic approach to target selection for structural genomics: solution structure of YciH

1999 • 45 citations

1H and 15N Resonance Assignments and Structure of the N-Terminal Domain of Escherichia coli Initiation Factor 3

1995 • 34 citations

Structure of the β Subunit of Translation Initiation Factor 2 from the Archaeon Methanococcus jannaschii: A Representative of the eIF2β/eIF5 Family of Proteins^,

2002 • 22 citations

Structure and dynamics of translation initiation factor aIF‐1A from the archaeon Methanococcus jannaschii determined by NMR spectroscopy

2001 • 18 citations

Structure and dynamics of translation initiation factor aIF-1A from the archaeon Methanococcus jannaschii determined by NMR spectroscopy

2001 • 14 citations