Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

1997 • 1,228 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

1995 • 1,181 citations

Autophosphorylation at Thr ²⁸⁶ of the α Calcium-Calmodulin Kinase II in LTP and Learning

1998 • 1,045 citations

Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles

1999 • 1,024 citations

A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

1996 • 948 citations

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

1994 • 889 citations

Synaptic Activation Causes the mRNA for the IEG Arc to Localize Selectively near Activated Postsynaptic Sites on Dendrites

1998 • 807 citations

Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro

1988 • 800 citations

Somatodendritic expression of an immediate early gene is regulated by synaptic activity.

1995 • 695 citations

The mRNA 5′ cap-binding protein eIF4E and control of cell growth

1998 • 651 citations

Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain

1985 • 625 citations

Postsynaptic protein phosphorylation and LTP

2000 • 559 citations

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.

1986 • 548 citations

Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats

1984 • 508 citations

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

1994 • 501 citations

Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.

1994 • 488 citations

CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses

1998 • 485 citations

Selective Targeting of Newly Synthesized Arc mRNA to Active Synapses Requires NMDA Receptor Activation

2001 • 451 citations

Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation

1988 • 447 citations

NMDA receptor-mediated control of protein synthesis at developing synapses

2000 • 365 citations

Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis

1984 • 346 citations

Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2.

1987 • 339 citations

A Complex Program of Striatal Gene Expression Induced by Dopaminergic Stimulation

1998 • 333 citations

Eukaryotic initiation factor eIF2

1999 • 328 citations

Correlations between immediate early gene induction and the persistence of long-term potentiation

1993 • 297 citations

Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.

1992 • 297 citations

Activity-Dependent β-Adrenergic Modulation of Low Frequency Stimulation Induced LTP in the Hippocampal CA1 Region

1996 • 282 citations

A Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation Requiring cAMP in the Medial Perforant Pathway of Rat Hippocampal Slices

1996 • 279 citations

Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization

1989 • 275 citations

Influence of actinomycin D, a RNA synthesis inhibitor, on long‐term potentiation in rat hippocampal neurons in vivo and in vitro.

1996 • 267 citations

Local protein synthesis and its role in synapse-specific plasticity

2000 • 248 citations

Identification of calmodulin-dependent protein kinase III and its major Mr 100,000 substrate in mammalian tissues.

1985 • 217 citations

Regulation of elongation factor‐2 by multisite phosphorylation

1993 • 181 citations

Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions

2000 • 178 citations

Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence

1998 • 167 citations

Glutamate-dependent phosphorylation of elongation factor-2 and inhibition of protein synthesis in neurons.

1997 • 163 citations

Glutamate-Dependent Phosphorylation of Elongation Factor-2 and Inhibition of Protein Synthesis in Neurons

1997 • 159 citations

Stimulus-induced coordinate changes in mRNA abundance in single postsynaptic hippocampal CA1 neurons

1992 • 159 citations

Pairing the cholinergic agonist carbachol with patterned Schaffer collateral stimulation initiates protein synthesis in hippocampal CA1 pyramidal cell dendrites via a muscarinic, NMDA-dependent mechanism

1993 • 141 citations

Activation of arc, a Putative “Effector” Immediate Early Gene, by Cocaine in Rat Brain

1995 • 131 citations

Changes in protein synthesis accompanying long-term potentiation in the dentate gyrus in vivo

1993 • 115 citations

Adenylyl Cyclase Activation Modulates Activity-Dependent Changes in Synaptic Strength and Ca²⁺/Calmodulin-Dependent Kinase II Autophosphorylation

1999 • 109 citations

Differential expression of immediate early genes after hippocampal long-term potentiation in awake rats

1993 • 97 citations

mRNA Trafficking and Local Protein Synthesis at the Synapse

1999 • 96 citations

Decreased Protein Phosphatase 2A Activity in Hippocampal Long‐Term Potentiation

2000 • 95 citations

Mutation of Tyr307 and Leu309 in the Protein Phosphatase 2A Catalytic Subunit Favors Association with the α4 Subunit Which Promotes Dephosphorylation of Elongation Factor-2

1999 • 88 citations

Selective Alteration of Long-Term Potentiation-Induced Transcriptional Response in Hippocampus of Aged, Memory-Impaired Rats

1997 • 87 citations

A critical level of protein synthesis is required for long‐term potentiation

1987 • 83 citations

Cyclic AMP-dependent protein kinase phosphorylates rabbit reticulocyte elongation factor-2 kinase and induces calcium-independent activity

1993 • 81 citations

Activity of protein phosphatases against initiation factor-2 and elongation factor-2

1990 • 80 citations

Translation initiation factor 4E

1999 • 70 citations

N -methyl- <scp>d</scp> -aspartate receptor activation and visual activity induce elongation factor-2 phosphorylation in amphibian tecta: A role for N -methyl- <scp>d</scp> -aspartate receptors in controlling protein synthesis

1997 • 70 citations

Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity

2001 • 69 citations

Regulation of protein-synthesis elongation-factor-2 kinase by cAMP in adipocytes

1998 • 53 citations

Protein Synthesis Inhibition Blocks the Induction of Mossy Fiber Long-Term PotentiationIn Vivo

2000 • 40 citations

cAMP inhibits translation by inducing Ca²⁺/calmodulin‐independent elongation factor 2 kinase activity in IPC‐81 cells

1999 • 40 citations

Dendrites as compartments for macromolecular synthesis.

1994 • 40 citations

6 Calcium-dependent regulation of protein synthesis

1995 • 39 citations

Autophosphorylation of type II CaM kinase in hippocampal neurons: localization of phospho- and dephosphokinase with complementary phosphorylation site-specific antibodies.

1993 • 37 citations

Regulation of Eukaryotic Initiation Factor 4E Phosphorylation in the Nervous System of Aplysia californica

2000 • 24 citations