Evidence that fragile X mental retardation protein is a negative regulator of translation

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding

1993 • 721 citations

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

1993 • 632 citations

A point mutation in the FMR-1 gene associated with fragile X mental retardation

1993 • 619 citations

FMRP Associates with Polyribosomes as an mRNP, and the I304N Mutation of Severe Fragile X Syndrome Abolishes This Association

1997 • 509 citations

mRNA Silencing in Erythroid Differentiation: hnRNP K and hnRNP E1 Regulate 15-Lipoxygenase Translation from the 3′ End

1997 • 501 citations

SMN oligomerization defect correlates with spinal muscular atrophy severity

1998 • 493 citations

Essential role for KH domains in RNA binding: Impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome

1994 • 442 citations

Tissue specific expression of FMR–1 provides evidence for a functional role in fragile X syndrome

1993 • 387 citations

The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals

1996 • 383 citations

Understanding the molecular basis of fragile X syndrome

2000 • 357 citations

The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.

1995 • 332 citations

(Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features

2000 • 267 citations

Essential Role for the Tudor Domain of SMN in Spliceosomal U snRNP Assembly: Implications for Spinal Muscular Atrophy

1999 • 250 citations

SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins

1999 • 243 citations

FXR1, an autosomal homolog of the fragile X mental retardation gene.

1995 • 238 citations

The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes

1997 • 235 citations

Purified Recombinant Fmrp Exhibits Selective RNA Binding as an Intrinsic Property of the Fragile X Mental Retardation Protein

1998 • 193 citations

Isolation of an FMRP-Associated Messenger Ribonucleoprotein Particle and Identification of Nucleolin and the Fragile X-Related Proteins as Components of the Complex

1999 • 179 citations

From factors to mechanisms: translation and translational control in eukaryotes

1999 • 150 citations

Alternative splicing in the fragile X gene FMR1

1993 • 135 citations

A nuclear role for the Fragile X mental retardation protein.

1996 • 130 citations

Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains

1999 • 95 citations

Analysis of Domains Affecting Intracellular Localization of the FMRP Protein

1997 • 78 citations

The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins

2000 • 60 citations

Molecular characterization of the protein products of the fragile X syndrome gene and the survival of motor neurons gene.

1996 • 13 citations