Brain-derived Neurotrophic Factor Enhances Neuronal Translation by Activating Multiple Initiation Processes

Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval

2000 • 2,546 citations

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 • 2,096 citations

Neurotrophins and Neuronal Plasticity

1995 • 1,937 citations

Physiology of the Neurotrophins

1996 • 1,908 citations

Protein synthesis and memory: A review.

1984 • 1,450 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Translational control of gene expression

2001 • 1,192 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

1996 • 948 citations

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

1999 • 928 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression

2000 • 922 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Toward a molecular definition of long-term memory storage

1996 • 685 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E

1999 • 635 citations

Postsynaptic protein phosphorylation and LTP

2000 • 559 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis

1999 • 510 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro

1999 • 325 citations

Molecular mechanisms for the control of translation by insulin

1997 • 257 citations

Local protein synthesis and its role in synapse-specific plasticity

2000 • 248 citations

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

1996 • 238 citations

Synaptic plasticity in cortical systems

1999 • 235 citations

Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis

1998 • 230 citations

Signal Transduction Pathways That Regulate Eukaryotic Protein Synthesis

1999 • 199 citations

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

1997 • 199 citations

Regulation of translation initiation factors by signal transduction

1998 • 195 citations

In Situ Hybridization of trkB and trkC Receptor mRNA in Rat Forebrain and Association with High‐affinity Binding of [¹²⁵I]BDNF, [¹²⁵I]NT‐4/5 and [¹²⁵I]NT‐3

1994 • 190 citations

Interaction of RAFT1 with Gephyrin Required for Rapamycin-Sensitive Signaling

1999 • 186 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures.

1991 • 182 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures

1991 • 164 citations

Brain‐Derived Neurotrophic Factor Increases the Stimulation‐Evoked Release of Glutamate and the Levels of Exocytosis‐Associated Proteins in Cultured Cortical Neurons from Embryonic Rats

1997 • 146 citations

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

1994 • 138 citations

Capture of a protein synthesis-dependent component of long-term depression

2000 • 127 citations

6 Regulation of Ribosomal Recruitment in Eukaryotes

2000 • 117 citations

Differences in survival‐promoting effects and intracellular signaling properties of BDNF and IGF‐1 in cultured cerebral cortical neurons

2001 • 109 citations

Requirement for Akt (Protein Kinase B) in Insulin-induced Activation of Glycogen Synthase and Phosphorylation of 4E-BP1 (PHAS-1)

1999 • 102 citations

T-cell Activation Leads to Rapid Stimulation of Translation Initiation Factor eIF2B and Inactivation of Glycogen Synthase Kinase-3

1996 • 95 citations

Brain-derived Neurotrophic Factor Induces Rapid and Transient Release of Glutamate through the Non-exocytotic Pathway from Cortical Neurons

1998 • 88 citations

Insulin‐stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway

1996 • 76 citations

Two Different Signal Transduction Pathways Are Implicated in the Regulation of Initiation Factor 2B Activity in Insulin-like Growth Factor-1-stimulated Neuronal Cells

2000 • 70 citations

Insulin and IGF‐I Receptor Signaling in Cultured Neurons^a

1993 • 55 citations

Epidermal Growth Factor Prevents Oxygen‐triggered Apoptosis and Induces Sustained Signalling in Cultured Rat Cerebral Cortical Neurons

1995 • 52 citations

Characterization of the Phosphoproteins and Protein Kinase Activity in mTOR Immunoprecipitates

1998 • 28 citations

Roles of neurotrophins on synaptic development and functions in the central nervous system.

1998 • 25 citations

Neurotrophic Factors in Brain Synaptic Plasticity

1997 • 19 citations

Purification and Characterization of Guanine Nucleotide‐Exchange Factor, eIF‐2B, and p37 Calmodulin‐Binding Protein from Calf Brain

1995 • 19 citations