The molecular biology of head and neck cancer

The Hallmarks of Cancer

2000 • 27,569 citations

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

1999 • 8,737 citations

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer

2003 • 6,072 citations

Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer

2010 • 5,874 citations

Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck

2006 • 4,800 citations

Papillomaviruses and cancer: from basic studies to clinical application

2002 • 3,873 citations

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

Patterns of Cancer Incidence, Mortality, and Prevalence Across Five Continents: Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World

2006 • 3,314 citations

ERBB receptors and cancer: the complexity of targeted inhibitors

2005 • 3,200 citations

Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers

2000 • 3,004 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer

2007 • 2,615 citations

Role of angiogenesis in tumor growth and metastasis

2002 • 2,412 citations

Role of angiogenesis in tumor growth and metastasis

2002 • 2,310 citations

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

2009 • 2,296 citations

Integrating cell-signalling pathways with NF-κB and IKK function

2006 • 2,260 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Genomic instability — an evolving hallmark of cancer

2010 • 2,081 citations

Tumor Angiogenesis

2008 • 1,854 citations

Incidence Trends for Human Papillomavirus–Related and –Unrelated Oral Squamous Cell Carcinomas in the United States

2008 • 1,522 citations

Genetic progression model for head and neck cancer: implications for field cancerization.

1996 • 1,340 citations

Dissecting the metastatic cascade

2004 • 1,268 citations

Human Papillomavirus and Oral Cancer: The International Agency for Research on Cancer Multicenter Study

2003 • 1,212 citations

A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications.

2003 • 1,174 citations

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

2004 • 1,057 citations

Nuclear localization of EGF receptor and its potential new role as a transcription factor

2001 • 1,049 citations

TGFβ signalling: a complex web in cancer progression

2010 • 1,049 citations

Human Keratinocytes That Express hTERT and Also Bypass a p16^INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

2000 • 1,003 citations

Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management

2008 • 860 citations

Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.

1993 • 837 citations

Molecular Assessment of Histopathological Staging in Squamous-Cell Carcinoma of the Head and Neck

1995 • 759 citations

TP53Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck

2007 • 732 citations

A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen

2007 • 726 citations

Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta‐analysis

2007 • 724 citations

Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral‐induced carcinoma?

2009 • 705 citations

Frequent clones of p53-mutated keratinocytes in normal human skin

1996 • 678 citations

Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression

2004 • 659 citations

Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older

2008 • 641 citations

Natural history of potentially malignant oral lesions and conditions: an overview of the literature

2007 • 611 citations

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails.

1992 • 609 citations

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.

1996 • 587 citations

Human papillomavirus (HPV) in head and neck cancer

2005 • 560 citations

Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment

1996 • 521 citations

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

2005 • 520 citations

An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas

2005 • 512 citations

Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting

2006 • 481 citations

AIS is an oncogene amplified in squamous cell carcinoma

2000 • 465 citations

Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.

2000 • 420 citations

p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

2006 • 418 citations

Genetic Patterns in Head and Neck Cancers That Contain or Lack Transcriptionally Active Human Papillomavirus

2004 • 406 citations

Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control

2002 • 392 citations

Epidermal Growth Factor Receptor Copy Number Alterations Correlate With Poor Clinical Outcome in Patients With Head and Neck Squamous Cancer

2007 • 391 citations

Low-Level Expression of MicroRNAs let-7d and miR-205 Are Prognostic Markers of Head and Neck Squamous Cell Carcinoma

2009 • 360 citations

Marked differences in survival rate between smokers and nonsmokers with HPV 16‐associated tonsillar carcinomas

2008 • 348 citations

High Incidence of Head and Neck Squamous Cell Carcinoma in Patients With Fanconi Anemia

2003 • 344 citations

Second primary tumors and field cancerization in oral and oropharyngeal cancer: Molecular techniques provide new insights and definitions

2002 • 338 citations

A Two-Stage, p16^INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

2002 • 334 citations

Over‐expression of the EGF receptor is a hallmark of squamous cell carcinomas

1986 • 330 citations

Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.

1992 • 322 citations

Intensity-Modulated Radiotherapy Reduces Radiation-Induced Morbidity and Improves Health-Related Quality of Life: Results of a Nonrandomized Prospective Study Using a Standardized Follow-Up Program

2008 • 310 citations

Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas

2001 • 309 citations

Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications.

2001 • 309 citations

Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma

2006 • 304 citations

Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients

2006 • 304 citations

Frequent p53 mutations in head and neck cancer.

1992 • 287 citations

The clinical relevance of human papillomavirus testing: relationship between analytical and clinical sensitivity

2003 • 280 citations

Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma

2005 • 276 citations

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

2009 • 276 citations

Clinical implications and utility of field cancerization

2007 • 272 citations

MicroRNA Expression Ratio Is Predictive of Head and Neck Squamous Cell Carcinoma

2009 • 267 citations

Genomic organization, chromosomal localization, and independent expression of human cyclin D genes

1992 • 264 citations

The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma

2009 • 258 citations

Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma

2009 • 255 citations

Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus

2005 • 252 citations

Prognostic Significance of Vascular Endothelial Growth Factor Immunohistochemical Expression in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis

2005 • 249 citations

Induction Chemotherapy and Cetuximab for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Results From a Phase II Prospective Trial

2009 • 244 citations

FHIT gene alterations in head and neck squamous cell carcinomas.

1996 • 243 citations

Gene Expression Profiles Identify Epithelial-to-Mesenchymal Transition and Activation of Nuclear Factor-κB Signaling as Characteristics of a High-risk Head and Neck Squamous Cell Carcinoma

2006 • 240 citations

Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck

2005 • 236 citations

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells

1999 • 234 citations

Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma

2009 • 226 citations

Inverse Relationship between Human Papillomavirus-16 Infection and Disruptivep53Gene Mutations in Squamous Cell Carcinoma of the Head and Neck

2008 • 225 citations

HGF and c-Met Participate in Paracrine Tumorigenic Pathways in Head and Neck Squamous Cell Cancer

2009 • 224 citations

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

2009 • 209 citations

Gene amplification and overexpression of EGF receptor in squamous cell carcinomas of the head and neck

1989 • 204 citations

Matrix metalloproteases in head and neck cancer

2006 • 197 citations

PIK3CA Mutations in Head and Neck Squamous Cell Carcinoma

2006 • 191 citations

Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

1996 • 188 citations

CSMD1 Is a Novel Multiple Domain Complement-Regulatory Protein Highly Expressed in the Central Nervous System and Epithelial Tissues

2006 • 187 citations

Prevalence and expression of human papillomavirus in tonsillar carcinomas, indicating a possible viral etiology

1992 • 186 citations

A case-control study confirms that microsatellite assay can identify patients at risk of developing oral squamous cell carcinoma within a field of cancerization.

2000 • 176 citations

Interventions for treating oral leukoplakia

2006 • 173 citations

Salivary analysis of oral cancer biomarkers

2009 • 172 citations

Genetically Altered Fields as Origin of Locally Recurrent Head and Neck Cancer

2004 • 169 citations

Pitfalls and procedures in the histopathological diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of the role of pathology in prognosis

2008 • 167 citations

Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.

1998 • 164 citations

Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging

2009 • 163 citations

Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma

2009 • 158 citations

Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma

2005 • 156 citations

Mutated p53 as a molecular marker for the diagnosis of head and neck cancer

2002 • 156 citations

Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma

2002 • 154 citations

Is the p53 inactivation frequency in squamous cell carcinomas of the head and neck underestimated? Analysis of p53 exons 2-11 and human papillomavirus 16/18 E6 transcripts in 123 unselected tumor specimens.

2003 • 149 citations

PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma

2006 • 140 citations

Showering c-MET-dependent cancers with drugs

2008 • 132 citations

Phosphoproteomics strategies for the functional analysis of signal transduction

2006 • 130 citations

Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA.

1998 • 129 citations

Long‐Term Quality of Life After Total Laryngectomy and Postoperative Radiotherapy Versus Concurrent Chemoradiotherapy for Laryngeal Preservation

2008 • 129 citations

Differential expression and activation of NF‐κB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection

2006 • 128 citations

Comparative molecular and histological grading of epithelial dysplasia of the oral cavity and the oropharynx

2003 • 124 citations

Proteomic analysis reveals successive aberrations in protein expression from healthy mucosa to invasive head and neck cancer

2006 • 121 citations

Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas

2008 • 120 citations

Refining the diagnosis of oropharyngeal squamous cell carcinoma using human papillomavirus testing

2010 • 118 citations

Prognostic Significance of Epidermal Growth Factor Receptor Phosphorylation and Mutation in Head and Neck Squamous Cell Carcinoma

2009 • 118 citations

DNA ploidy analysis by image cytometry helps to identify oral epithelial dysplasias with a high risk of malignant progression

2008 • 118 citations

A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains.

2001 • 118 citations

Multicentric origin of intraoral carcinoma.

1946 • 107 citations

Squamous Cell Carcinoma Related Oncogene/DCUN1D1 Is Highly Conserved and Activated by Amplification in Squamous Cell Carcinomas

2006 • 98 citations

Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways

2010 • 95 citations

Patterns of chromosomal alterations in metastasizing and nonmetastasizing primary head and neck carcinomas.

1997 • 95 citations

Genome-Wide Analyses on Loss of Heterozygosity in Head and Neck Squamous Cell Carcinomas

2003 • 94 citations

Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma

2002 • 89 citations

Genetic Instability in Epithelial Tissues at Risk for Cancer

2001 • 89 citations

Utilization of Free Tissue Transfer in Head and Neck Surgery

2007 • 89 citations

Transcript Map of the 8p23 Putative Tumor Suppressor Region

2001 • 86 citations

Molecular techniques and genetic alterations in head and neck cancer

2008 • 85 citations

Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck

1997 • 85 citations

Amplicon Mapping and Expression Profiling Identify the Fas-Associated Death Domain Gene as a New Driver in the 11q13.3 Amplicon in Laryngeal/Pharyngeal Cancer

2007 • 84 citations

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

2001 • 81 citations

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

2001 • 76 citations

Disruption of transforming growth factor β-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4

2006 • 71 citations

Differential Proteomics Identifies Protein Biomarkers That Predict Local Relapse of Head and Neck Squamous Cell Carcinomas

2009 • 70 citations

Genetic Polymorphisms and Head and Neck Cancer Outcomes: A Review

2008 • 68 citations

Deleted in Colorectal Cancer Is a Putative Conditional Tumor-Suppressor Gene Inactivated by Promoter Hypermethylation in Head and Neck Squamous Cell Carcinoma

2006 • 67 citations

Modern Criteria to Establish Human Cancer Etiology

2004 • 66 citations

Evaluation of cornulin, keratin 4, keratin 13 expression and grade of dysplasia for predicting malignant progression of oral leukoplakia

2009 • 62 citations

Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis.

2009 • 60 citations

Loss of heterozygosity at 9p and p53 immunopositivity in surgical margins predict local relapse in head and neck squamous cell carcinoma

2010 • 58 citations

Chromosome 8 Allelic Loss and the Outcome of Patients With Squamous Cell Carcinoma of the Supraglottic Larynx

1996 • 55 citations

Creating oral squamous cancer cells: A cellular model of oral–esophageal carcinogenesis

2005 • 52 citations

A noninvasive genetic screening test to detect oral preneoplastic lesions

2005 • 51 citations

New chromosomal regions with high-level amplifications in squamous cell carcinomas of the larynx and pharynx, identified by comparative genomic hybridization

2001 • 50 citations

Prognostic Significance of Vascular Endothelial Growth Factor in Squamous Cell Carcinomas of the Tonsil in Relation to Human Papillomavirus Status and Epidermal Growth Factor Receptor

2009 • 49 citations

Cytogenetic abnormalities in 106 oral squamous cell carcinomas

2005 • 47 citations

MYC Amplification in Squamous Cell Carcinomas of the Head and Neck

1996 • 46 citations

Multistep laryngeal carcinogenesis helps our understanding of the field cancerisation phenomenon: a review

2004 • 44 citations

Screening for Oral Precancer with Noninvasive Genetic Cytology

2009 • 42 citations

Localization of a putative tumor suppressor gene in the sub-telomeric region of chromosome 8p

1999 • 41 citations

The Mode of Origin of Tumors. Solitary Localized Squamous Cell Growths of the Skin

1944 • 38 citations

Unraveling the Chromosomal Aberrations of Head and Neck Squamous Cell Carcinoma: A Review

2005 • 38 citations

Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma

2010 • 38 citations

Attenuated Transforming Growth Factor β Signaling Promotes Nuclear Factor-κB Activation in Head and Neck Cancer

2009 • 35 citations

Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31

2003 • 34 citations

Attenuated type II TGF‐β receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination

2004 • 29 citations

Chromosomal aberrations in squamous cell carcinomas of the upper aerodigestive tract: biologic insights and clinical opportunities

2005 • 26 citations

Chemoprevention of squamous cell carcinoma of the head and neck

2007 • 26 citations