Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck

2006 • 4,800 citations

Cancer Statistics, 2003

2003 • 3,302 citations

EGFR and cancer prognosis

2001 • 2,068 citations

Head and Neck Cancer

2001 • 1,258 citations

Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.

2002 • 1,173 citations

Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival

1998 • 1,083 citations

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

1994 • 932 citations

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1992 • 853 citations

Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.

1993 • 837 citations

Multicenter Phase II Study of Erlotinib, an Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck

2003 • 803 citations

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

2000 • 667 citations

Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme.

2003 • 647 citations

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

1995 • 633 citations

Phase II Trial of ZD1839 in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

2003 • 616 citations

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

1990 • 593 citations

The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling

1997 • 591 citations

A constitutively active epidermal growth factor receptor cooperates with disruption of G₁ cell-cycle arrest pathways to induce glioma-like lesions in mice

1998 • 560 citations

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.

1995 • 465 citations

Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors.

1983 • 456 citations

Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor

1990 • 415 citations

A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis.

1996 • 407 citations

Epidermal Growth Factor Receptor–Targeted Immunoliposomes Significantly Enhance the Efficacy of Multiple Anticancer Drugs In vivo

2005 • 370 citations

Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-X _L and caspase-3-like proteases

1998 • 348 citations

EGF mutant receptor vIII as a molecular target in cancer therapy.

2001 • 330 citations

Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII.

1997 • 327 citations

Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor

1998 • 304 citations

Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells

2004 • 290 citations

Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.

1995 • 278 citations

Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.

2002 • 275 citations

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors

2006 • 252 citations

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.

1993 • 246 citations

Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck

2005 • 236 citations

Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs

2003 • 234 citations

Expression of Activated Epidermal Growth Factor Receptors, Ras-Guanosine Triphosphate, and Mitogen-activated Protein Kinase in Human Glioblastoma Multiforme Specimens

1999 • 230 citations

Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors.

2003 • 228 citations

Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.

2001 • 204 citations

Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.

2001 • 171 citations

Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation

2003 • 169 citations

Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).

2002 • 168 citations

Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin

2004 • 167 citations

Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma

2005 • 156 citations

Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells

2002 • 149 citations

Cisplatinum and Bleomycin for advanced or recurrent squamous cell carcinoma of the head and neck: a randomised factorial phase III controlled trial

1985 • 143 citations

Epidermal growth factor receptor and response of head-and-neck carcinoma to therapy

2004 • 131 citations

Expression of constitutively activated EGFRvlll in non‐small cell lung cancer

2003 • 129 citations

Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis

2002 • 123 citations

Retinoic acid normalizes the increased gene transcription rate of TGF–α and EGFR in head and neck cancer cell lines

1996 • 120 citations

Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells

2004 • 114 citations

Expression of Oncogenic Epidermal Growth Factor Receptor Family Kinases Induces Paclitaxel Resistance and Alters β-Tubulin Isotype Expression

2000 • 112 citations

Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas

2005 • 101 citations

EGFR-mediated cell cycle regulation.

2002 • 97 citations

Targeting Epidermal Growth Factor Receptor in Head and Neck Cancer

2022 • 94 citations

Distribution of epidermal growth factor receptor gene amplification in brain tumours and correlation to prognosis

1995 • 77 citations

Mutation of p53 in head and neck squamous cell carcinoma correlates with Bcl‐2 expression and increased susceptibility to cisplatin‐induced apoptosis

2004 • 47 citations

Intragenic mutation analysis of the human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes.

1999 • 46 citations

Cetuximab in recurrent/metastatic (R&M) squamous cell carcinoma of the head and neck (SCCHN) refractory to first-line platinum-based therapies

2005 • 26 citations

Expression of a truncated epidermal growth factor receptor in oral squamous cell carcinomas

2000 • 12 citations