HGF and c-Met Participate in Paracrine Tumorigenic Pathways in Head and Neck Squamous Cell Cancer

An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

2007 • 714 citations

HGF/SF Is Present in Normal Adult Skeletal Muscle and Is Capable of Activating Satellite Cells

1998 • 674 citations

Functional Expression and Mutations of c-Met and Its Therapeutic Inhibition with SU11274 and Small Interfering RNA in Non–Small Cell Lung Cancer

2005 • 554 citations

Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members

2008 • 518 citations

c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention

2004 • 511 citations

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.

2003 • 491 citations

Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas

2000 • 330 citations

Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer.

1994 • 301 citations

Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma.

2001 • 281 citations

Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer.

1995 • 267 citations

Biology, cytogenetics, and sensitivity to immunological effector cells of new head and neck squamous cell carcinoma lines.

1989 • 254 citations

The Ras/Raf/MAPK Pathway

2006 • 248 citations

Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma.

1996 • 240 citations

Functional Analysis of c-Met/Hepatocyte Growth Factor Pathway in Malignant Pleural Mesothelioma

2006 • 193 citations

Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas

2006 • 189 citations

Molecular markers of head and neck squamous cell carcinoma: Promising signs in need of prospective evaluation

2005 • 172 citations

Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion

2007 • 171 citations

Establishment and characterization of two new squamous cell carcinoma cell lines derived from tumors of the head and neck.

1988 • 156 citations

c-Met Is a Potentially New Therapeutic Target for Treatment of Human Melanoma

2007 • 155 citations

Targeting the c-MET signaling pathway for cancer therapy

2008 • 133 citations

Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma.

2002 • 132 citations

In vitro radiation resistance among cell lines established from patients with squamous cell carcinoma of the head and neck

1991 • 115 citations

Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.

2003 • 113 citations

Targeting Epidermal Growth Factor Receptor and Src Pathways in Head and Neck Cancer

2008 • 93 citations

Aberrant Expression of Cortactin in Head and Neck Squamous Cell Carcinoma Cells Is Associated with Enhanced Cell Proliferation and Resistance to the Epidermal Growth Factor Receptor Inhibitor Gefitinib

2007 • 92 citations

Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation

2001 • 86 citations

Genetic and Expression Profiles of Squamous Cell Carcinoma of the Head and Neck Correlate with Cisplatin Sensitivity and Resistance in Cell Lines and Patients

2004 • 84 citations

Activated c‐Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer

2002 • 83 citations

Role of angiogenic factors: Coexpression of interleukin‐8 and vascular endothelial growth factor in patients with head and neck squamous carcinoma

1999 • 83 citations

Effect of c-Met Expression on Survival in Head and Neck Squamous Cell Carcinoma

2006 • 81 citations

Regulation of HGF and SDF-1 expression by oral fibroblasts – Implications for invasion of oral cancer

2007 • 75 citations

Identification and partial characterization of receptor binding sites for HGF on rat hepatocytes

1990 • 69 citations

Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinoma

2005 • 62 citations

Association of Extracellular Cleavage of E-Cadherin Mediated by MMP-7 with HGF-Induced in vitro Invasion in Human Stomach Cancer Cells

2007 • 60 citations

Overexpression of scatter factor and its receptor (c‐met) in oral squamous cell carcinoma

1998 • 56 citations

HGF and c-MET as potential orchestrators of invasive growth in head and neck squamous cell carcinoma

2007 • 53 citations

Angiogenic heterogeneity in head and neck squamous cell carcinoma: biological and therapeutic implications

2008 • 53 citations

Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma

2008 • 51 citations

Detection ofMET oncogene/hepatocyte growth factor receptor in lymph node metastases from head and neck squamous cell carcinomas

1997 • 48 citations

Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy

2004 • 47 citations

The Ras/Raf/MAPK Pathway

2006 • 46 citations

Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis

2008 • 45 citations

Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion

2007 • 41 citations

Small molecule c‐MET inhibitor PHA665752: Effect on cell growth and motility in papillary thyroid carcinoma

2008 • 34 citations

Serum hepatocyte growth factor as a marker of tumor activity in head and neck squamous cell carcinoma

2007 • 33 citations

A novel activating role of SRC and STAT3 on HGF transcription in human breast cancer cells

2007 • 30 citations

Elevated Hepatocyte Growth Factor Level Correlates With Poor Outcome in Early-Stage and Late-Stage Adenocarcinoma of the Lung

2004 • 17 citations

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