Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

2003 • 1,572 citations

Head and Neck Cancer

2001 • 1,258 citations

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

2001 • 1,206 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

The Fanconi anaemia/BRCA pathway

2003 • 819 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Inflammation: Gearing the journey to cancer

2008 • 777 citations

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

2006 • 620 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer.

1999 • 478 citations

TGF-β and cancer

2005 • 463 citations

Profiling early head and neck cancer

2005 • 438 citations

The Fanconi Anemia/BRCA pathway: new faces in the crowd

2005 • 398 citations

KrasG12D and Smad4/Dpc4 Haploinsufficiency Cooperate to Induce Mucinous Cystic Neoplasms and Invasive Adenocarcinoma of the Pancreas

2007 • 366 citations

High Incidence of Head and Neck Squamous Cell Carcinoma in Patients With Fanconi Anemia

2003 • 344 citations

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

2006 • 314 citations

Oncogenes and tumour suppressors take on centrosomes

2007 • 306 citations

Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology

2007 • 287 citations

Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma

2005 • 276 citations

SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

2007 • 271 citations

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice

2000 • 241 citations

Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival

2003 • 227 citations

Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder

2004 • 210 citations

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption ofSmad4 andPten in mice

2006 • 199 citations

Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma

2006 • 197 citations

Overexpression of Transforming Growth Factor β1 in Head and Neck Epithelia Results in Inflammation, Angiogenesis, and Epithelial Hyperproliferation

2004 • 191 citations

Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma

2004 • 180 citations

TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch

2008 • 164 citations

DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.

1996 • 164 citations

Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair

2002 • 130 citations

Clinical significance of MMP‐2 and MMP‐9 in patients with oral cancer

2007 • 125 citations

Activation of Bone Morphogenetic Protein/Smad Signaling in Bronchial Epithelial Cells during Airway Inflammation

2002 • 121 citations

Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin

2005 • 111 citations

Cancer Targets in the Ras Pathway

2005 • 109 citations

Inducible Activation of Oncogenic K- ras Results in Tumor Formation in the Oral Cavity

2004 • 109 citations

Targeted Disruption of Smad4 in Mouse Epidermis Results in Failure of Hair Follicle Cycling and Formation of Skin Tumors

2005 • 107 citations

Squamous cell carcinoma and mammary abscess formation through squamous metaplasia inSmad4/Dpc4conditional knockout mice

2003 • 99 citations

Identification of new minimally lost regions on 18q in head and neck squamous cell carcinoma.

2000 • 97 citations

Microenvironmental Genomic Alterations and Clinicopathological Behavior in Head and Neck Squamous Cell Carcinoma

2007 • 97 citations

Smad4 and transforming growth factor beta1 expression in patients with squamous cell carcinoma of the esophagus.

2002 • 91 citations

A distinct expression of CC chemokines by macrophages in nasopharyngeal carcinoma: Implication for the intense tumor infiltration by T lymphocytes and macrophages

2001 • 82 citations

Smad3 Knockout Mice Exhibit a Resistance to Skin Chemical Carcinogenesis

2004 • 81 citations

Genome‐Wide Profiling of Oral Squamous Cell Carcinoma by Array‐Based Comparative Genomic Hybridization

2006 • 80 citations

Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells

2003 • 79 citations

Disruption of transforming growth factor β-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4

2006 • 71 citations

Decreased Smad4 expression in the transforming growth factor‐β signaling pathway during progression of esophageal squamous cell carcinoma

2002 • 71 citations

Downregulation of Fanconi Anemia Genes in Sporadic Head and Neck Squamous Cell Carcinoma

2007 • 67 citations

TGFβ1/Smad3 counteracts BRCA1-dependent repair of DNA damage

2005 • 63 citations

Mouse models for human head and neck squamous cell carcinomas

2006 • 62 citations

Cancer-Associated Transforming Growth Factor β Type II Receptor Gene Mutant Causes Activation of Bone Morphogenic Protein-Smads and Invasive Phenotype

2008 • 61 citations

Identification of Novel Prognosticators of Outcome in Squamous Cell Carcinoma of the Head and Neck

2004 • 56 citations

Presence of multiple incontiguous deleted regions at the long arm of chromosome 18 in head and neck cancer.

1998 • 55 citations

Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse

2006 • 50 citations

Gene expression of differentiation-specific keratins (4/13 and 1/10) in normal human buccal mucosa.

1998 • 42 citations

Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues

2003 • 41 citations

Genetic abnormalities associated with nodal metastasis in head and neck cancer

2003 • 30 citations

Distinct roles of individual Smads in skin carcinogenesis

2007 • 19 citations