Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases.

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

1993 • 374 citations

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

1996 • 372 citations

ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases

1999 • 365 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.

1988 • 338 citations

Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements

1995 • 300 citations

Cell-free activation of a DNA-binding protein by epidermal growth factor

1993 • 263 citations

Platelet-Derived Growth Factor Induces Phosphorylation of Multiple JAK Family Kinases and STAT Proteins

1996 • 247 citations

A JAK1/JAK2 Chimera Can Sustain Alpha and Gamma Interferon Responses

1997 • 216 citations

In vitro activation of Stat3 by epidermal growth factor receptor kinase

1996 • 195 citations

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

1996 • 188 citations

Receptor tyrosine kinases and their targets

1994 • 177 citations

B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase.

1990 • 169 citations

Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor

1995 • 157 citations

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

1996 • 123 citations

Stat5 is a physiological substrate of the insulin receptor

1997 • 122 citations

The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cδ

1997 • 112 citations

Abrogation of Interleukin-3 Dependence of Myeloid Cells by the v-src Oncogene Requires SH2 and SH3 Domains Which Specify Activation of STATs

1997 • 108 citations

Constitutive Activation of JAK1 in Src-transformed Cells

1997 • 88 citations

Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF β-receptor juxtamembrane and kinase insert domains

1998 • 85 citations

cDNA Cloning and Expression of a Human Platelet-Derived Growth Factor (PDGF) Receptor Specific for B-Chain-Containing PDGF Molecules

1988 • 76 citations

Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts

1996 • 75 citations

Formation of STAT5-containing DNA Binding Complexes in Response to Colony-stimulating Factor-1 and Platelet-derived Growth Factor

1996 • 69 citations

STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation

1999 • 64 citations

Distinct Mechanisms of Activation of Stat1 and Stat3 by Platelet-Derived Growth Factor Receptor in a Cell-Free System

1999 • 63 citations

Association and direct activation of signal transducer and activator of transcription1alpha by platelet-derived growth factor receptor.

1998 • 56 citations

The Effect of Platelet‐Derived Growth Factor and Adipogenic Hormones on the Expression of CCAAT/Enhancer‐Binding Proteins in 3T3‐L1 Cells in Serum‐Free Conditions

1997 • 16 citations