Novel submicroscopic extrachromosomal elements containing amplified genes in human cells

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

Solenoidal model for superstructure in chromatin.

1976 • 1,223 citations

Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field

1986 • 920 citations

Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis

1984 • 887 citations

An electrophoretic karyotype for yeast.

1985 • 787 citations

GENE AMPLIFICATION

1984 • 580 citations

Antigenic variation in trypanosoma brucei analyzed by electrophoretic separation of chromosome-sized DNA molecules

1984 • 368 citations

Size variation in chromosomes from independent cultured isolates of Plasmodium falciparum

1985 • 201 citations

Stable Amplified DNA in Drug-Resistant Leishmania Exists as Extrachromosomal Circles

1986 • 124 citations

Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line

1985 • 91 citations

Multiple forms of human dihydrofolate reductase messenger RNA

1982 • 84 citations

Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines.

1982 • 43 citations

Human dihydrofolate reductase gene is located in chromosome 5 and is unlinked to the related pseudogenes.

1984 • 38 citations