Mechanism of action of aryl hydrocarbon receptor antagonists: Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions

1980 • 827 citations

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

1988 • 455 citations

Identification of two transactlvation domains in the mouse oestrogen receptor

1989 • 303 citations

The Regulation of Cytochrome P-450 Gene Expression

1986 • 283 citations

The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1987 • 251 citations

The Ah locus: Correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA

1982 • 184 citations

Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor.

1991 • 136 citations

Human estrogen receptor forms multiple protein-DNA complexes.

1990 • 126 citations

Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity

1987 • 120 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric

1990 • 115 citations

Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: Structure-activity relationships as Ah receptor agonists and partial antagonists

1990 • 109 citations

The mechanism of action of α-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression

1990 • 86 citations

Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat

1988 • 86 citations

Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5'-ward of the cytochrome P1-450 gene.

1986 • 83 citations

Uterine Estrogen Receptor Interaction with Estrogen-Responsive DNA Sequencesin Vitro: Effects of Ligand Binding on Receptor-DNA Complexes

1990 • 73 citations

Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse hepa 1c1c7 cells

1991 • 73 citations

6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.

1988 • 73 citations

Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.

1989 • 58 citations

6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice

1989 • 57 citations

6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) is an antiestrogen in human and rodent cancer cell lines: Evidence for the role of the Ah receptor

1992 • 55 citations

Genetic and molecular analysis of the Ah receptor and of Cyp1a1 gene expression

1991 • 53 citations

Dioxin-Inducible Enhancer Region Upstream from the Mouse P₁450 Gene and Interaction with a Heterologous SV40 Promoter

1986 • 53 citations

Polychlorinated dibenzofurans as 2,3,7,8-tcdd antagonists: In vitro inhibition of monooxygenase enzyme induction

1986 • 50 citations

ISI Atlas of Science: Pharmacology

1989 • 48 citations

The binding of transformed aromatic hydrocarbon (Ah) receptor to its DNA recognition site is not affected by metal depletion

1990 • 42 citations

Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: Mechanistic studies using radiolabeled congeners

1989 • 30 citations

1-amino-3,7,8-trichlorodibenzo-P-dioxin: A specific antagonist for TCDD-induced myelotoxicity

1986 • 30 citations

Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: Mechanistic studies

1990 • 25 citations

Regulation of Cytochrome P₁-450 Gene Expression in Mouse Hepatoma Cells by 2,3,7,8-Tetrachloflodibenzo-p-Dioxin

1989 • 10 citations