Cholesterol Movement in Niemann-Pick Type C Cells and in Cells Treated with Amphiphiles

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

1997 • 1,440 citations

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1999 • 1,311 citations

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

1997 • 797 citations

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

1999 • 628 citations

Alteration of the Myometrial Plasma Membrane Cholesterol Content with .beta.-Cyclodextrin Modulates the Binding Affinity of the Oxytocin Receptor

1995 • 543 citations

Plasma Membranes Contain Half the Phospholipid and 90% of the Cholesterol and Sphingomyelin in Cultured Human Fibroblasts

1989 • 509 citations

Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Inhibition of Growth of Human Fibroblasts by 7-Ketocholesterol

1974 • 502 citations

Intracellular cholesterol transport

1999 • 416 citations

The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo

1999 • 375 citations

The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one

1989 • 315 citations

The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts.

1989 • 306 citations

Antibiotic Interaction with Model Membranes

1970 • 291 citations

Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts.

1987 • 249 citations

Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol

1999 • 240 citations

Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol.

1988 • 230 citations

Intracellular Cholesterol Transport and Compartmentation

1995 • 226 citations

Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes.

1988 • 203 citations

Group C Niemann‐Pick disease: faulty regulation of low‐density lipoprotein uptake and cholesterol storage in cultured fibroblasts

1987 • 196 citations

A genetic storage disorder in BALB/C mice with a metabolic block in esterification of exogenous cholesterol.

1984 • 188 citations

Disposition of intracellular cholesterol in human fibroblasts.

1991 • 181 citations

Role of Niemann-Pick Type C1 Protein in Intracellular Trafficking of Low Density Lipoprotein-derived Cholesterol

2000 • 179 citations

Localization of Niemann–Pick C1 protein in astrocytes: Implications for neuronal degeneration in Niemann– Pick type C disease

1999 • 179 citations

Niemann-Pick C1 protein: Obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization

1999 • 161 citations

Evidence for a Cholesterol Transport Pathway from Lysosomes to Endoplasmic Reticulum That Is Independent of the Plasma Membrane

1998 • 160 citations

Circulation of Cholesterol between Lysosomes and the Plasma Membrane

1998 • 136 citations

Differential accumulation of cholesterol in Golgi compartments of normal and Niemann-Pick type C fibroblasts incubated with LDL: a cytochemical freeze-fracture study

1993 • 135 citations

Role of Multidrug Resistance P-glycoproteins in Cholesterol Esterification

1997 • 134 citations

Type C Niemann-Pick disease. A parallel loss of regulatory responses in both the uptake and esterification of low density lipoprotein-derived cholesterol in cultured fibroblasts.

1986 • 125 citations

Cholesterol homeostasis. Modulation by amphiphiles.

1994 • 120 citations

Quantitation of the Pool of Cholesterol Associated with Acyl-CoA:Cholesterol Acyltransferase in Human Fibroblasts

1997 • 116 citations

Niemann–Pick disease type C

1998 • 108 citations

Rapid intracellular transport of LDL-derived cholesterol to the plasma membrane in cultured fibroblasts.

1990 • 108 citations

Role of the plasma membrane in cholesterol esterification in rat hepatoma cells

1993 • 102 citations

Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol.

1992 • 97 citations

Progesterone Inhibits Cholesterol Biosynthesis in Cultured Cells

1996 • 94 citations

Isolation and characterization of Chinese hamster ovary cell mutants deficient in acyl-coenzyme A:cholesterol acyltransferase activity.

1988 • 94 citations

Cholesterol accumulation in tissues of the Niemann-Pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ

1999 • 93 citations

The efflux of lysosomal cholesterol from cells.

1990 • 89 citations

Quantification of endocytosis-derived membrane traffic

1985 • 74 citations

The role of intracellular cholesterol transport in cholesterol homeostasis

1996 • 67 citations

The Fate of Cholesterol Exiting Lysosomes

1997 • 61 citations

Zymosterol is located in the plasma membrane of cultured human fibroblasts.

1990 • 45 citations

Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation

1997 • 39 citations

Four cholesterol-sensing proteins

1998 • 38 citations

Type C Niemann-Pick disease: cellular uncoupling of cholesterol homeostasis is linked to the severity of disruption in the intracellular transport of exogenously derived cholesterol

1991 • 37 citations

The NP-C gene: a key to pathways of intracellular cholesterol transport

1994 • 28 citations

Accumulation of cholesterol and GM2 ganglioside in cells cultured in the presence of progesterone: an implication for the basic defect in Niemann-Pick disease type C

1998 • 23 citations

Biological Implications of the Niemann-Pick C Mutation

1997 • 22 citations