Differential Effects of Sphingomyelin Hydrolysis and Cholesterol Transport on Oxysterol-binding Protein Phosphorylation and Golgi Localization

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1983 • 1,639 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

1997 • 1,440 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

Caveolae, DIGs, and the dynamics of sphingolipid—cholesterol microdomains

1997 • 783 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

Plasma Membranes Contain Half the Phospholipid and 90% of the Cholesterol and Sphingomyelin in Cultured Human Fibroblasts

1989 • 509 citations

A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane

1996 • 496 citations

Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation.

1994 • 425 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts

1988 • 323 citations

Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase.

1984 • 312 citations

Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane.

1990 • 304 citations

Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts

1995 • 302 citations

Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding.

1992 • 295 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

Intracellular Cholesterol Transport and Compartmentation

1995 • 226 citations

Sphingolipid metabolites: Members of a new class of lipid second messengers

1995 • 226 citations

Sphingomyelinase Treatment Induces ATP-independent Endocytosis

1998 • 204 citations

Sterol Carrier Protein-2 Is Involved in Cholesterol Transfer from the Endoplasmic Reticulum to the Plasma Membrane in Human Fibroblasts

1995 • 167 citations

Evidence for a Cholesterol Transport Pathway from Lysosomes to Endoplasmic Reticulum That Is Independent of the Plasma Membrane

1998 • 160 citations

Immunocytochemical localization of beta II subspecies of protein kinase C in rat brain.

1989 • 159 citations

cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper

1989 • 154 citations

The Distal Pathway of Lipoprotein-induced Cholesterol Esterification, but Not Sphingomyelinase-induced Cholesterol Esterification, Is Energy-dependent

1996 • 137 citations

Acyl coenzyme A:cholesterol acyl transferase in macrophages utilizes a cellular pool of cholesterol oxidase-accessible cholesterol as substrate.

1988 • 134 citations

Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function.

1995 • 133 citations

Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain

1997 • 118 citations

Rapid intracellular transport of LDL-derived cholesterol to the plasma membrane in cultured fibroblasts.

1990 • 108 citations

Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1

1997 • 106 citations

Protein kinase C mu is located at the Golgi compartment.

1996 • 105 citations

Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase

1994 • 102 citations

Plasma membrane sphingomyelin and the regulation of HMG-CoA reductase activity and cholesterol biosynthesis in cell cultures.

1991 • 92 citations

Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport.

1996 • 84 citations

The Dimeric and Catalytic Subunit Forms of Protein Phosphatase 2A from Rat Brain Are Stimulated by C2-Ceramide

1995 • 81 citations

Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content.

1994 • 71 citations

c-Jun Is a Downstream Target for Ceramide-activated Protein Phosphatase in A431 Cells

1996 • 70 citations

25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.

1995 • 68 citations

Effects of sphingomyelin and phosphatidylcholine degradation on cyclodextrin-mediated cholesterol efflux in cultured fibroblasts

1997 • 67 citations

Rapid turn-over of plasma membrane sphingomyelin and cholesterol in baby hamster kidney cells after exposure to sphingomyelinase

1990 • 63 citations

The Fate of Cholesterol Exiting Lysosomes

1997 • 61 citations

Cholesterol transport from plasma membranes to intracellular membranes is inhibited by 3β-[2-(diethylamino) ethoxy]androst-5-en-17-one

1994 • 50 citations

Reversible effects of sphingomyelin degradation on cholesterol distribution and metabolism in fibroblasts and transformed neuroblastoma cells

1990 • 45 citations

Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells

1995 • 43 citations

Cholesterol and sphingomyelin syntheses are regulated independently in cultured human intestinal cells, CaCo-2: role of membrane cholesterol and sphingomyelin content.

1993 • 38 citations

Effect of positively charged sphingomyelin liposomes on cholesterol metabolism of cells in culture

1983 • 36 citations

Analysis of a Chinese hamster ovary cell mutant with defective mobilization of cholesterol from the plasma membrane to the endoplasmic reticulum

1997 • 31 citations

Inhibition of acyl-CoA: cholesterol acyltransferase in chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide

1995 • 28 citations

Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A

1998 • 24 citations

Effect and Cellular Site of Action of Cysteine Protease Inhibitors on the Cholesterol Esterification Pathway in Macrophages and Chinese Hamster Ovary Cells

1995 • 14 citations