The assembly and secretion of apolipoprotein B-containing lipoproteins

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

1998 • 1,075 citations

Coat Proteins and Vesicle Budding

1996 • 955 citations

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

1992 • 741 citations

Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

1992 • 736 citations

COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes

1998 • 624 citations

Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B.

1991 • 421 citations

Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice

1999 • 415 citations

ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase

1998 • 388 citations

Subcellular localization of B apoprotein of plasma lipoproteins in rat liver.

1976 • 359 citations

Molecules in the ARF Orbit

1998 • 346 citations

Identification of a Form of Acyl-CoA:Cholesterol Acyltransferase Specific to Liver and Intestine in Nonhuman Primates

1998 • 298 citations

The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70

1997 • 285 citations

COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast

1995 • 278 citations

The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas

1992 • 230 citations

Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells.

1994 • 218 citations

ADP-ribosylation factor is required for vesicular trafficking between the endoplasmic reticulum and the cis-Golgi compartment.

1992 • 213 citations

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

1999 • 188 citations

Ubiquitin-Proteasome Pathway Mediates Intracellular Degradation of Apolipoprotein B

1996 • 187 citations

Studies on the assembly of apo B-100-containing lipoproteins in HepG2 cells.

1988 • 186 citations

The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins 1 1Edited by A. R. Fersht

1999 • 177 citations

The assembly and secretion of ApoB 100-containing lipoproteins in Hep G2 cells. ApoB 100 is cotranslationally integrated into lipoproteins.

1992 • 170 citations

Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.

1991 • 169 citations

Inhibition of the Microsomal Triglyceride Transfer Protein Blocks the First Step of Apolipoprotein B Lipoprotein Assembly but Not the Addition of Bulk Core Lipids in the Second Step

1996 • 164 citations

Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain

1996 • 158 citations

Regulated Co-translational Ubiquitination of Apolipoprotein B100

1998 • 154 citations

Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency

1998 • 146 citations

Co-translational Degradation of Apolipoprotein B100 by the Proteasome Is Prevented by Microsomal Triglyceride Transfer Protein

1997 • 142 citations

Origin of triacylglycerol moiety of plasma very low density lipoproteins in the rat: structural studies

1995 • 140 citations

The Microsomal Triglyceride Transfer Protein Catalyzes the Post-translational Assembly of Apolipoprotein B-100 Very Low Density Lipoprotein in McA-RH7777 Cells

1998 • 129 citations

Lipoprotein assembly. Apolipoprotein B size determines lipoprotein core circumference.

1992 • 128 citations

Overt and latent activities of diacylglycerol acytransferase in rat liver microsomes: possible roles in very-low-density lipoprotein triacylglycerol secretion

1997 • 124 citations

Multiple Molecular Chaperones Interact with Apolipoprotein B during Its Maturation

1998 • 98 citations

Proteasome-mediated Degradation of Apolipoprotein B Targets Both Nascent Peptides Cotranslationally Before Translocation and Full-length Apolipoprotein B After Translocation into the Endoplasmic Reticulum

1998 • 97 citations

A Common Binding Site on the Microsomal Triglyceride Transfer Protein for Apolipoprotein B and Protein Disulfide Isomerase

1999 • 95 citations

Amino Acids 430–570 in Apolipoprotein B Are Critical for Its Binding to Microsomal Triglyceride Transfer Protein

1998 • 94 citations

Calnexin and Other Factors That Alter Translocation Affect the Rapid Binding of Ubiquitin to ApoB in the Sec61 Complex

1998 • 94 citations

Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly

1997 • 91 citations

A Two-site Model for ApoB Degradation in HepG2 Cells

1997 • 89 citations

Proteolysis-coupled secretion of the N terminus of apolipoprotein B. Characterization of a transient, translocation arrested intermediate.

1994 • 88 citations

Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured rat hepatocytes

1998 • 87 citations

Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.

1993 • 86 citations

Reversible dissociation of coatomer: Functional characterization of a β/δ-coat protein subcomplex

1998 • 78 citations

Brefeldin A Reversibly Inhibits the Assembly of ApoB Containing Lipoproteins in McA-RH7777 Cells

1995 • 72 citations

Apoprotein B100, an Inefficiently Translocated Secretory Protein, Is Bound to the Cytosolic Chaperone, Heat Shock Protein 70

1995 • 71 citations

Origin of hepatic very-low-density lipoprotein triacylglycerol: the contribution of cellular phospholipid

1996 • 67 citations

Quality Control by Proteases in the Endoplasmic Reticulum

1998 • 59 citations

Identification of Cysteine Pairs within the Amino-terminal 5% of Apolipoprotein B Essential for Hepatic Lipoprotein Assembly and Secretion

1997 • 40 citations

Intracellular Assembly and Degradation of Apolipoprotein B-100-containing Lipoproteins in Digitonin-permeabilized HEP G2 Cells

1997 • 37 citations

Identification of Domains in Apolipoprotein B100 That Confer a High Requirement for the Microsomal Triglyceride Transfer Protein

1999 • 35 citations

Translocation-arrested Apolipoprotein B Evades Proteasome Degradation via a Sterol-sensitive Block in Ubiquitin Conjugation

1999 • 31 citations

Chinese Hamster Ovary Cells Require the Coexpression of Microsomal Triglyceride Transfer Protein and Cholesterol 7α-Hydroxylase for the Assembly and Secretion of Apolipoprotein B-containing Lipoproteins

1999 • 25 citations