Accumulation of somatic hypermutation and antigen‐driven selection in rapidly cycling surface Ig⁺ germinal center (GC) B cells which occupy GC at a high frequency during the primary antihapten response in mice

Sequences of proteins of immunological interest

1984 • 3,427 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice.

1983 • 810 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

How B and T cells talk to each other

1994 • 659 citations

BCL-6 protein is expressed in germinal-center B cells

1995 • 582 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

Germinal centres in T-cell-dependent antibody responses

1992 • 442 citations

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

1995 • 425 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.

1993 • 367 citations

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2

1995 • 358 citations

The Dynamic Nature of the Antibody Repertoire

1988 • 321 citations

Origin of Antibody Variation

1966 • 314 citations

Antigen-driven B cell differentiation in vivo.

1993 • 308 citations

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

1993 • 283 citations

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

1986 • 279 citations

Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

1988 • 275 citations

Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.

1983 • 274 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

1993 • 271 citations

Peanut lectin binding properties of germinal centers of mouse lymphoid tissue

1980 • 259 citations

Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies

1979 • 254 citations

Somatic hypermutation

1995 • 248 citations

A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex.

1995 • 231 citations

Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores.

1990 • 226 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.

1995 • 224 citations

Targeting of non-lg sequences in place of the V segment by somatic hyper mutation

1995 • 223 citations

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.

1990 • 200 citations

The Evolution of B-Cell Clones

1990 • 185 citations

Functional and molecular characterization of single, (4‐hydroxy‐3‐nitrophenyl)acetyl (NP)‐specific, IgG₁⁺ B cells from antibody‐secreting and memory B cell pathways in the C57BL/6 immune response to NP

1992 • 159 citations

Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse

1989 • 157 citations

Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

1985 • 153 citations

CD43 (S7) expression identifies peripheral B cell subsets.

1994 • 145 citations

Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?

1988 • 135 citations

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.

1995 • 134 citations

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes.

1991 • 132 citations

In vivo obtained antigen presented by germinal center B cells to T cells in vitro.

1988 • 122 citations

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell‐dependent antigen

1992 • 119 citations

Allotypic specificities of murine IgD and IgM recognized by monoclonal antibodies.

1984 • 116 citations

T cells within germinal centers are specific for the immunizing antigen.

1993 • 110 citations

Mouse A-myb encodes a trans-activator and is expressed in mitotically active cells of the developing central nervous system, adult testis and B lymphocytes.

1994 • 108 citations

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

1993 • 107 citations

The germinal center reaction

1995 • 94 citations

Development of antibody diversity in single germinal centers: selective expansion of high‐affinity variants

1994 • 85 citations

Expression of Fas in B cells of the mouse germinal center and Fas-dependent killing of activated B cells

1995 • 73 citations

Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes.

1995 • 70 citations

Somatic Mutation of Immunoglobulin V Genes in Vitro

1996 • 64 citations

Soluble antigen can impede affinity maturation and the germinal center reaction but enhance extrafollicular immunoglobulin production.

1995 • 46 citations

Antigenic phenotype and functional characterization of human tonsil B cells

1988 • 34 citations

M17: a novel gene expressed in germinal centers

1994 • 34 citations

A form of immunologic tolerance through impairment of germinal center development.

1994 • 31 citations

Preferential utilization of the immature J_H segment and absence of somatic mutation in the CDR3 junction of the Ig H chain gene in three X-linked severe combined immunodeficiency patients

1994 • 16 citations

Analysis of function of a human antigen-presenting cell by xenogeneic interaction with mouse T cells

1994 • 3 citations