Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Determination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation

1991 • 1,123 citations

PROMOTIF—A program to identify and analyze structural motifs in proteins

1996 • 1,046 citations

Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure.

1990 • 1,013 citations

A workbench for multiple alignment construction and analysis

1991 • 1,005 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Crystal Structure of the Lactose Operon Repressor and Its Complexes with DNA and Inducer

1996 • 781 citations

3D domain swapping: A mechanism for oligomer assembly

1995 • 749 citations

[27] Local alignment statistics

1996 • 729 citations

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

1995 • 609 citations

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

1995 • 557 citations

The world according to bedgebog

1997 • 549 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain

1996 • 529 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Induction of midbrain dopaminergic neurons by Sonic hedgehog

1995 • 481 citations

Crystal Structure of LacI Member, PurR, Bound to DNA: Minor Groove Binding by α Helices

1994 • 369 citations

Protein splicing elements: inteins and exteins — a definition of terms and recommended nomenclature

1994 • 348 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog

1995 • 309 citations

The mechanism of protein splicing and its modulation by mutation.

1996 • 278 citations

Crystal Structure of PI-SceI, a Homing Endonuclease with Protein Splicing Activity

1997 • 254 citations

Structural classification of proteins: new superfamilies

1996 • 240 citations

Compilation and analysis of intein sequences

1997 • 204 citations

Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis

1995 • 200 citations

Activation of Glycosylasparaginase

1996 • 180 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

The crystal structure of α-bungarotoxin at 2.5 Å resolution: relation to solution structure and binding to acetylcholine receptor

1986 • 166 citations

Conserved sequence features of inteins (protein introns) and their use in identifying new inteins and related proteins

1994 • 163 citations

Modular organization of inteins and C‐terminal autocatalytic domains

1998 • 149 citations

Swaposins: circular permutations within genes encoding saposin homologues

1995 • 121 citations

[31] Treatment of multiwavelength anomalous diffraction data as a special case of multiple isomorphous replacement

1997 • 102 citations

Crystallization of a fragment of human fibronectin: Introduction of methionine by site‐directed mutagenesis to allow phasing via selenomethionine

1994 • 90 citations

CardiotoxinV4II fromNaja mossambica mossambica

1990 • 79 citations

Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila

1995 • 76 citations

Statistical Modeling, Phylogenetic Analysis and Structure Prediction of a Protein Splicing Domain Common to Inteins and Hedgehog Proteins

1997 • 74 citations

Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage

1995 • 64 citations

Recombinant circle PCR and recombination PCR for site-specific mutagenesis without PCR product purification.

1992 • 60 citations

A protein splice-junction motif in hedgehog family proteins

1995 • 46 citations

Crystallization of nerve growth factor from mouse submaxillary glands.

1975 • 42 citations

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