Modular organization of inteins and C‐terminal autocatalytic domains

Basic local alignment search tool

1990 • 87,358 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Fitting a mixture model by expectation maximization to discover motifs in biopolymers.

1994 • 4,818 citations

Sequence Analysis of the Genome of the Unicellular Cyanobacterium Synechocystis sp. Strain PCC6803. II. Sequence Determination of the Entire Genome and Assignment of Potential Protein-coding Regions (Supplement)

1996 • 2,455 citations

Sequence Analysis of the Genome of the Unicellular Cyanobacterium Synechocystis sp. Strain PCC6803. II. Sequence Determination of the Entire Genome and Assignment of Potential Protein-coding Regions

1996 • 2,046 citations

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

1996 • 2,043 citations

The α/β hydrolase fold

1992 • 2,024 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics

1997 • 1,147 citations

A workbench for multiple alignment construction and analysis

1991 • 1,005 citations

[2] Families of serine peptidases

1994 • 621 citations

The world according to bedgebog

1997 • 549 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain

1996 • 529 citations

Molecular structure of a gene, VMA1, encoding the catalytic subunit of H(+)-translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae.

1990 • 474 citations

Split Genes and RNA Splicing

1979 • 467 citations

Homing endonucleases: keeping the house in order

1997 • 466 citations

Protein Family Classification Based on Searching a Database of Blocks

1994 • 372 citations

Automated construction and graphical presentation of protein blocks from unaligned sequences

1995 • 321 citations

The mechanism of protein splicing and its modulation by mutation.

1996 • 278 citations

Homing of a DNA endonuclease gene by meiotic gene conversion in Saccharomyces cerevisiae

1992 • 275 citations

Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins

1997 • 274 citations

Crystal Structure of PI-SceI, a Homing Endonuclease with Protein Splicing Activity

1997 • 254 citations

Mechanisms of Intron Mobility

1995 • 248 citations

Protein Splicing Involving the Saccharomyces cerevisiae VMA Intein

1996 • 245 citations

Searching databases of conserved sequence regions by aligning protein multiple-alignments [published erratum appears in Nucleic Acids Res 1996 Nov 1;24(21):4372]

1996 • 223 citations

Compilation and analysis of intein sequences

1997 • 204 citations

Intervening sequences in an Archaea DNA polymerase gene.

1992 • 188 citations

Conserved sequence features of inteins (protein introns) and their use in identifying new inteins and related proteins

1994 • 163 citations

[Phospholipids of yeasts maintained on a n-alkanes].

1968 • 158 citations

Cutinase, a lipolytic enzyme with a preformed oxyanion hole

1994 • 157 citations

Amino acid sequence motif of group I intron endonucleases is conserved in open reading frames of group II introns

1994 • 146 citations

Genetic definition of a protein-splicing domain: Functional mini-inteins support structure predictions and a model for intein evolution

1997 • 137 citations

The Mycobacterium xenopi GyrA protein splicing element: characterization of a minimal intein

1997 • 134 citations

Protein splicing of the yeast TFP1 intervening protein sequence: a model for self-excision.

1993 • 125 citations

Protein splicing removes intervening sequences in an archaea DNA polymerase

1992 • 125 citations

PRINTS--a database of protein motif fingerprints.

1994 • 124 citations

Prokaryotic introns and inteins: a panoply of form and function

1995 • 113 citations

Protein Splicing of the Saccharomyces cerevisiae VMA Intein without the Endonuclease Motifs

1997 • 112 citations

Self‐splicing group I and group II introns encode homologous (putative) DNA endonucleases of a new family

1994 • 111 citations

Substitutions in Conserved Dodecapeptide Motifs That Uncouple the DNA Binding and DNA Cleavage Activities of PI-SceI Endonuclease

1995 • 107 citations

Evidence of selection for protein introns in the recAs of pathogenic mycobacteria.

1994 • 106 citations

Ribonucleotide reductase in the archaeon Pyrococcus furiosus : A critical enzyme in the evolution of DNA genomes?

1997 • 77 citations

Statistical Modeling, Phylogenetic Analysis and Structure Prediction of a Protein Splicing Domain Common to Inteins and Hedgehog Proteins

1997 • 74 citations

Identification of Three Core Regions Essential for Protein Splicing of the Yeast Vma1 Protozyme

1997 • 71 citations

Mutations at the putative junction sites of the yeast VMA1 protein, the catalytic subunit of the vacuolar membrane H+-ATPase, inhibit its processing by protein splicing

1992 • 69 citations

Homing events in the gyrA gene of some mycobacteria.

1996 • 50 citations

A protein splice-junction motif in hedgehog family proteins

1995 • 46 citations

Post-translational Processing and Renal Expression of Mouse Indian Hedgehog

1997 • 28 citations

Identification and characterization of a cyanobacterial DnaX intein

1997 • 19 citations

Genetic tools in pathogenic nocardioform actinomycetes.

1996 • 3 citations