Interplay between the tumor suppressor p53 and TGFβ signaling shapes embryonic body axes inXenopus

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Surfing the p53 network

2000 • 6,487 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Normal Table of Xenopus Laevis (Daudin)

1958 • 4,561 citations

Controlling TGF-beta signaling.

2000 • 1,806 citations

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

2000 • 1,658 citations

Controlling TGF-β signaling

2000 • 1,522 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

The p53 pathway

1999 • 1,322 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

1991 • 799 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

Morphogen gradient interpretation

2001 • 738 citations

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

2000 • 650 citations

Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

2000 • 643 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

A subset of p53-deficient embryos exhibit exencephaly

1995 • 577 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

2004 • 514 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

1995 • 510 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1998 • 472 citations

High-frequency developmental abnormalities in p53-deficient mice

1995 • 464 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP‐2 and BMP‐4

1995 • 344 citations

Directed evolution of green fluorescent protein by a new versatile PCR strategy for site-directed and semi-random mutagenesis

2000 • 341 citations

Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos

1989 • 316 citations

Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4

1997 • 311 citations

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif

2000 • 277 citations

Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos

1989 • 264 citations

PTGF-β , a type β transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway

2000 • 244 citations

Nodal Signaling in Early Vertebrate Embryos

2001 • 243 citations

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

1999 • 241 citations

Alternatively Spliced Variant of Smad2 Lacking Exon 3

1999 • 235 citations

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.

1995 • 225 citations

Analyses of p53 Target Genes in the Human Genome by Bioinformatic and Microarray Approaches

2001 • 166 citations

Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53

2000 • 162 citations

Bimodal and graded expression of theXenopushomeobox geneXhox3during embryonic development

1989 • 161 citations

BMP-4-responsive regulation of dorsal–ventral patterning by the homeobox protein Mix.1

1996 • 152 citations

An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.

1992 • 143 citations

Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.

1996 • 123 citations

Analysis of competence and of Brachyury autoinduction by use of hormoneinducible Xbra

1997 • 121 citations

FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo

1999 • 118 citations

The Role of FAST-1 and Smads in Transcriptional Regulation by Activin during Early Xenopus Embryogenesis

1999 • 111 citations

P53 activity is essential for normal development in Xenopus

1997 • 108 citations

Regulation of Epidermal Induction by BMP2 and BMP7 Signaling

1997 • 106 citations

Tumour suppressors: A developing role for p53?

1997 • 104 citations

Wild-type human p53 activates the human epidermal growth factor receptor promoter.

1994 • 97 citations

pXeX, a vector for efficient expression of cloned sequences in Xenopus embryos

1994 • 95 citations

TGF-β signalling pathways in early Xenopus development

2001 • 86 citations

DNA Sequences Mediating the Transcriptional Response of theMix.2Homeobox Gene to Mesoderm Induction

1996 • 79 citations

FGF-mediated mesoderm induction involves the Src-family kinase Laloo

1998 • 75 citations

Early Posterior/Ventral Fate Specification in the Vertebrate Embryo

2001 • 70 citations

Overexpression of wild-type p53 interferes with normal development in Xenopus laevis embryos.

1994 • 53 citations

Xenopus Embryonic E2F Is Required for the Formation of Ventral and Posterior Cell Fates during Early Embryogenesis

2000 • 52 citations

Stabilization and Expression of High Levels of p53 during Early Development in Xenopus laevis

1993 • 40 citations

Expression of the Xhox3 Homeobox Protein in Xenopus Embryos: Blocking Its Early Function Suggests the Requirement of Xhox3 for Normal Posterior Development

1991 • 35 citations

Xenopus p63 expression in early ectoderm and neurectoderm

2001 • 34 citations

Structure and Function of a Sea Urchin Orthodenticle-Related Gene (HpOtx)

1998 • 26 citations

Activation of the p21CIP1/WAF1 promoter by bone morphogenetic protein-2 in mouse B lineage cells

2001 • 25 citations