An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide

1985 • 1,191 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Tumor suppressor genes

1991 • 775 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Frequent mutation of the p53 gene in human esophageal cancer.

1990 • 393 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Frequent Mutations in the p53 Tumor Suppressor Gene in Human Leukemia T-Cell Lines

1990 • 296 citations

A variation in the structure of the protein-coding region of the human p53 gene

1988 • 286 citations

p53 is frequently mutated in Burkitt's lymphoma cell lines.

1991 • 259 citations

Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.

1985 • 227 citations

Neoplastic Transformation of Human Epidermal Keratinocytes by AD12-SV40 and Kirsten Sarcoma Viruses

1985 • 223 citations

Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus that were derived from nasopharyngeal carcinomas.

1989 • 208 citations

Mutations in the p53 gene in primary human breast cancers.

1991 • 165 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

Preserved foods and nasopharyngeal carcinoma: a case-control study in Guangxi, China.

1988 • 157 citations

Salted fish and inhalants as risk factors for nasopharyngeal carcinoma in Malaysian Chinese.

1983 • 151 citations

p53 mutations in ovarian cancer: a late event?

1991 • 151 citations

From gene to carcinogen: a rapidly evolving field in molecular epidemiology.

1991 • 146 citations

Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma

1983 • 117 citations

Establishment and characterization of two epithelial tumor cell lines (hne‐1 and hone‐1) latently infected with epstein‐barr virus and derived from nasopharyngeal carcinomas

1990 • 88 citations

Viral Infections of Humans

1982 • 85 citations

Mutation of the p53 gene in a differentiated human thyroid carcinoma cell line, but not in primary thyroid tumours.

1991 • 80 citations

Detection of loss of heterozygosity in the p53 gene in renal cell carcinoma and bladder cancer using the polymerase chain reaction

1991 • 60 citations

Epstein-Barr Virus Early Antigen Induction in Raji Cells by Chinese Medicinal Herbs

1983 • 46 citations

Isolation and partial characterization of a transformation‐associated sequence from human nasopharyngeal carcinoma

1991 • 20 citations

Protein kinase activities in immune complexes of simian virus 40 large T-antigen and transformation-associated cellular p53 protein.

1984 • 15 citations

DNA sequences in human nasopharyngeal carcinoma cells that specify susceptibility to tumor promoter-induced neoplastic transformation

1987 • 13 citations

A simple method using PCR for direct sequencing of genomic DNA from frozen tumor tissue embedded in optimal cutting temperature compound.

1992 • 10 citations

Protein Kinase Activities in Immune Complexes of Simian Virus 40 Large T-Antigen and Transformation-Associated Cellular p53 Protein

1984 • 9 citations

[Epstein-Barr virus early antigen induction in Raji cells by Chinese medicinal herbs].

1984 • 5 citations