Matrix remodeling in the ovary: regulation and functional role of the plasminogen activator and matrix metalloproteinase systems

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Physiology of Reproduction

1988 • 7,765 citations

Cutaneous Wound Healing

1999 • 5,878 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

1999 • 1,280 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Physiology of Reproduction

2000 • 1,184 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Activation mechanisms of matrix metalloproteinases.

1997 • 1,134 citations

Proteolytic remodeling of extracellular matrix

1995 • 1,086 citations

Structure of a serpin–protease complex shows inhibition by deformation

2000 • 1,054 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

Hormonal Regulation of the Differentiation of Cultured Ovarian Granulosa Cells*

1984 • 1,015 citations

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

1997 • 844 citations

Maturation of ovarian follicles: actions and interactions of pituitary and ovarian hormones on follicular cell differentiation.

1980 • 837 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

2000 • 792 citations

Leptin accelerates the onset of puberty in normal female mice.

1997 • 768 citations

Ovarian Follicle Atresia: A Hormonally Controlled Apoptotic Process*

1994 • 728 citations

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

The Matrix Metalloproteinases and Their Inhibitors

1992 • 604 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Matrix metal loproteinases and the development of cancer

1996 • 569 citations

Impaired wound healing in mice with a disrupted plasminogen gene

1996 • 568 citations

Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases

2000 • 527 citations

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.

1996 • 496 citations

Ovarian plasminogen activator: Relationship to ovulation and hormonal regulation

1975 • 440 citations

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

1995 • 440 citations

Plasmin and Matrix Metalloproteinases in Vascular Remodeling

2001 • 436 citations

The Plasminogen (Fibrinolytic) System

1999 • 424 citations

Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages.

1984 • 418 citations

Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in Mice

1995 • 390 citations

α1-Antitrypsin and the serpins: variation and countervariation

1985 • 384 citations

TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

2000 • 383 citations

Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice

1997 • 352 citations

Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

1993 • 344 citations

Transcriptional Control of Matrix Metalloproteinases and the Tissue Inhibitors of Matrix Metalloproteinases

1997 • 332 citations

The Vertebrate ovary

1978 • 307 citations

Invasion of the trophoblasts

1992 • 305 citations

ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function

2000 • 305 citations

In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

1998 • 290 citations

Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos.

1989 • 287 citations

Follicular development and its control

1993 • 258 citations

Angiogenesis in reproductive tissues

1986 • 258 citations

Follicular plasminogen and plasminogen activator and the effect of plasmin on ovarian follicle wall

1975 • 248 citations

Matrix metalloproteinases

1997 • 247 citations

Matrix metalloproteinases

1997 • 231 citations

Cyclic Changes in the Matrix Metalloproteinase System in the Ovary and Uterus1

2001 • 209 citations

Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution

2001 • 199 citations

Ovarian Follicular Development: From Physiology to Molecular Biology

1987 • 198 citations

Follicular Plasminogen Activator: Involvement in Ovulation*

1985 • 191 citations

CULTURED GRANULOSA CELLS PRODUCE TWO PLASMINOGEN ACTIVATORS AND AN ANT IACTIVATOR, EACH REGULATED DIFFERENTLY BY GONADOTROPINS.

1985 • 181 citations

Development and Disease in Proteinase-Deficient Mice

1998 • 177 citations

The Biochemistry of Cancer Dissemination

1997 • 170 citations

Substrate specificities and activation mechanisms of matrix metalloproteinases

1991 • 164 citations

Ovarian Expression of a Disintegrin and Metalloproteinase with Thrombospondin Motifs During Ovulation in the Gonadotropin-Primed Immature Rat1

2000 • 138 citations

Preovulatory Changes in Ovarian Expression of Collagenases and Tissue Metalloproteinase Inhibitor Messenger Ribonucleic Acid: Role of Eicosanoids*

1991 • 135 citations

Suppression of Ovulation Rate by Antibodies to Tissue-Type Plasminogen Activator and α₂-Antiplasmin*

1989 • 131 citations

Regulation and Localization of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in the Mouse Ovary during Gonadotropin-Induced Ovulation1

1999 • 128 citations

Ovulation as a Tissue Remodelling Process

1995 • 122 citations

Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host.

1996 • 121 citations

Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators.

1995 • 116 citations

The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival

1999 • 116 citations

Plasminogen activator in the rat ovary. Production and gonadotropin regulation of the enzyme in granulosa and thecal cells.

1985 • 104 citations

An Analysis of Follicle Development and Ovum Maturation

1986 • 103 citations

Tissue‐specific and time‐coordinated hormone regulation of plasminogen‐activator‐inhibitor type I and tissue‐type plasminogen activator in the rat ovary during gonadotropin‐induced ovulation

1991 • 92 citations

Temporal expression of tissue inhibitors of metalloproteinases in mouse reproductive tissues during gestation

1993 • 89 citations

Structure-function relationships in serpins: current concepts and controversies.

1998 • 86 citations

Coordinate induction and activation of metalloproteinase and ascorbate depletion in structural luteolysis.

1993 • 84 citations

Differential distribution of gelatinases and tissue inhibitor of metalloproteinase-1 in the rat ovary

1998 • 83 citations

A suggestion as to the process of ovulation and ovarian cyst formation

1916 • 82 citations

Enzyme-induced rupture of rabbit Graafian follicle

1965 • 81 citations

Gelatinase and Proteoglycanase Activity during the Periovulatory Period in the Rat1

1992 • 77 citations

Mouse ovarian granulosa cells produce urokinase-type plasminogen activator, whereas the corresponding rat cells produce tissue-type plasminogen activator.

1987 • 76 citations

Assessment of the Role of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) during the Periovulatory Period in Female Mice Lacking a Functional TIMP-1 Gene1

1997 • 75 citations

The Extraction of a Tissue Collagenase Associated with Ovulation in the Rat1

1985 • 74 citations

Ovulation and the mechanism of follicle rupture

1974 • 71 citations

The structure of a serpin–protease complex revealed by intramolecular distance measurements using donor–donor energy migration and mapping of interaction sites

2000 • 70 citations

Transient and cell‐specific expression of tissue‐type plasminogen activator and plasminogen‐activator‐inhibitor type 1 results in controlled and directed proteolysis during gonadotropin‐induced ovulation

1993 • 69 citations

Coordinated and Cell-Specific Regulation of Membrane Type Matrix Metalloproteinase 1 (MT1-MMP) and Its Substrate Matrix Metalloproteinase 2 (MMP-2) by Physiological Signals during Follicular Development and Ovulation

1998 • 69 citations

Distinct Expression of Gelatinase A [Matrix Metalloproteinase (MMP)-2], Collagenase-3 (MMP-13), Membrane Type MMP 1 (MMP-14), and Tissue Inhibitor of MMPs Type 1 Mediated by Physiological Signals During Formation and Regression of the Rat Corpus Luteum1

1999 • 69 citations

Luteal Regression in the Normally Cycling Rat: Apoptosis, Monocyte Chemoattractant Protein-1, and Inflammatory Cell Involvement1

1999 • 67 citations

The urokinase receptor: Structure, regulation and inhibitor-mediated internalization

1994 • 66 citations

Intrafollicular Distribution of Plasminogen Activators and Their Hormonal Regulationin Vitro*

1986 • 65 citations

Ovulation in Plasminogen-Deficient Mice¹

1999 • 63 citations

Temporal and Spatial Expression of Tissue Inhibitors of Metalloproteinases during the Natural Ovulatory Cycle of the Mouse1

1996 • 60 citations

Expression and Activity of Ovarian Tissue Inhibitors of Metalloproteinases during Pseudopregnancy in the Rat1

1995 • 58 citations

Serpins: Mobile conformations in a family of proteinase inhibitors

1992 • 57 citations

Coordinated and cell-specific induction of both physiological plasminogen activators creates functionally redundant mechanisms for plasmin formation during ovulation.

1996 • 53 citations

Localization of Preovulatory Expression of Plasminogen Activator Inhibitor Type-1 and Tissue Inhibitor of Metalloproteinase Type-1 mRNAs in the Rat Ovary1

1992 • 49 citations

Collagenase, Gelatinase, and Proteoglycanase Messenger Ribonucleic Acid Expression and Activity during Luteal Development, Maintenance, and Regression in the Pseudopregnant Rat Ovary1

1996 • 49 citations

Hormonal regulation of the fibrinolytic components in the ovary

1993 • 47 citations

Collagenase and Gelatinase Messenger Ribonucleic Acid Expression and Activity During Follicular Development in the Rat Ovary1

1999 • 46 citations

Cellular mechanisms of luteolysis

1994 • 44 citations

The effects of proteolytic enzymes on in vitro ovulation in the rabbit

1987 • 37 citations

Coordinated expression of tissue-type plasminogen activator and plasminogen activator inhibitor type 1 during corpus luteum formation and luteolysis in the adult pseudopregnant rat.

1996 • 35 citations

In vivo measurement of rat ovarian collagenolytic activities.

1993 • 33 citations

Coordinate induction and activation of metalloproteinase and ascorbate depletion in structural luteolysis

1993 • 32 citations

Serpins: mobile conformations in a family of proteinase inhibitors

1992 • 32 citations

Luteal blood flow and plasma steroids in rats with corpora lutea of different ages

1981 • 26 citations

Coordinated and Cell-Specific Regulation of Membrane Type Matrix Metalloproteinase 1 (MT1-MMP) and Its Substrate Matrix Metalloproteinase 2 (MMP-2) by Physiological Signals during Follicular Development and Ovulation

1998 • 21 citations

Regulation and Localization of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in the Mouse Ovary during Gonadotropin-Induced Ovulation

1999 • 21 citations

Distinct Expression of Gelatinase A [Matrix Metalloproteinase (MMP)-2], Collagenase-3 (MMP-13), Membrane Type MMP 1 (MMP-14), and Tissue Inhibitor of MMPs Type 1 Mediated by Physiological Signals During Formation and Regression of the Rat Corpus Luteum

1999 • 18 citations

Coordinated and cell-specific induction of both physiological plasminogen activators creates functionally redundant mechanisms for plasmin formation during ovulation

1996 • 17 citations

Ovulation in Plasminogen-Deficient Mice

1999 • 17 citations

Hormonal regulation of tissue inhibitors of metalloproteinases during follicular development in the rat ovary

1996 • 15 citations

Proteinase — Protein inhibitor interactions

1994 • 15 citations

Stromelysin-3 Is Induced in Mouse Ovarian Follicles Undergoing Hormonally Controlled Apoptosis, but This Metalloproteinase Is Not Required for Follicular Atresia1

2001 • 15 citations

In vivo measurement of rat ovarian collagenolytic activities

1993 • 8 citations

Coordinated expression of tissue-type plasminogen activator and plasminogen activator inhibitor type 1 during corpus luteum formation and luteolysis in the adult pseudopregnant rat

1996 • 8 citations