The development of a FACS‐based strategy for the isolation of Shigella flexneri mutants that are deficient in intercellular spread

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Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

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Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells

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The Tripartite Type III Secreton of Shigella flexneri Inserts Ipab and Ipac into Host Membranes

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Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulation

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A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a

1986 • 312 citations

Cloning of plasmid DNA sequences involved in invasion of HeLa cells by Shigella flexneri

1985 • 306 citations

Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocytelike cell line Caco-2

1990 • 301 citations

Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri

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Plaque formation by virulent Shigella flexneri

1985 • 253 citations

IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells

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virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence

1989 • 240 citations

Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin

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Virulence-associated genetic regions comprising 31 kilobases of the 230-kilobase plasmid in Shigella flexneri 2a

1988 • 195 citations

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread

1992 • 178 citations

Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cells.

1995 • 174 citations

Contact of Shigella with host cells triggers release of Ipa invasins and is an essential function of invasiveness.

1995 • 168 citations

Role of the rfe gene in the biosynthesis of the Escherichia coli O7-specific lipopolysaccharide and other O-specific polysaccharides containing N-acetylglucosamine

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Cadherin expression is required for the spread of Shigella flexneri between epithelial cells

1994 • 164 citations

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1996 • 159 citations

Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane

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Effect of mutations in Shigella flexneri chromosomal and plasmid‐encoded lipopolysaccharide genes on invasion and serum resistance

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Exerimental acute colitis in the Rhesus monkey following peroral infection with Shigella flexneri. An electron microscope study.

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OmpC is involved in invasion of epithelial cells by Shigella flexneri

1993 • 124 citations

The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneri

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Expression of four virulence antigens of Shigella flexneri is positively regulated at the transcriptional level by the 30 kilo Dalton virF protein

1988 • 118 citations

Regulation of O‐antigen chain length is required for Shigella flexneri virulence

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Intercellular spread of Shigella flexneri through a monolayer mediated by membranous protrusions and associated with reorganization of the cytoskeletal protein vinculin

1991 • 110 citations

Induction of type III secretion in Shigella flexneri is associated with differential control of transcription of genes encoding secreted proteins

1998 • 108 citations

Mini-Tn10 transposon derivatives for insertion mutagenesis and gene delivery into the chromosome of Gram-negative bacteria

1995 • 105 citations

Unipolar reorganization of F-actin layer at bacterial division and bundling of actin filaments by plastin correlate with movement of Shigella flexneri within HeLa cells

1992 • 100 citations

Identification and characterization of a chromosomal virulence gene, vacJ, required for intercellular spreading of Shigella flexneri

1994 • 97 citations

Development and characterization of a monoclonal antibody specific for Listeria monocytogenes and Listeria innocua

1991 • 89 citations

Identification and characterization of virK, a virulence‐associated large plasmid gene essential for intercellular spreading of Shigella flexneri

1992 • 83 citations

Identification of a novel virulence gene, virA, on the large plasmid of Shigella, involved in invasion and intercellular spreading

1995 • 83 citations

Virulence‐associated chromosomal loci of Shigella flexneri identified by random Tn5 insertion mutagenesis

1991 • 79 citations

Role of the rfe gene in the synthesis of the O8 antigen in Escherichia coli K-12

1994 • 75 citations

Stress fiber-based movement of Shigella flexneri within cells

1991 • 68 citations

HeLa cell invasiveness and O antigen of Shigella flexneri as separate and prerequisite attributes of virulence to evoke keratoconjunctivitis in guinea pigs

1983 • 68 citations

Characterization of B-cell epitopes on IpaB, an invasion-associated antigen of Shigella flexneri: identification of an immunodominant domain recognized during natural infection

1993 • 64 citations

Movement along actin filaments of the perijunctional area and de novo polymerization of cellular actin are required for Shigella flexneri colonization of epithelial Caco-2 cell monolayers

1992 • 64 citations

Nucleotide sequence of the rhamnose biosynthetic operon of Shigella flexneri 2a and role of lipopolysaccharide in virulence

1994 • 63 citations

Type III machines of Gram-negative pathogens: injecting virulence factors into host cells and more

1999 • 60 citations

Identification and characterization of B-cell epitopes of IpaC, an invasion-associated protein of Shigella flexneri

1992 • 53 citations

Cloning of regions required for contact hemolysis and entry into LLC-MK2 cells from Shigella sonnei form I plasmid: virF is a positive regulator gene for these phenotypes

1989 • 51 citations