Apoptosis as a proinflammatory event: What can we learn from bacteria-induced cell death?

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Shigella flexneri induces apoptosis in infected macrophages

1992 • 1,130 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

1992 • 818 citations

Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells

1993 • 722 citations

A bacterial invasin induces macrophage apoptosis by binding directly to ICE.

1996 • 405 citations

Salmonella spp. are cytotoxic for cultured macrophages

1996 • 379 citations

New Concepts in the Immunopathogenesis of HIV Infection

1995 • 323 citations

IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.

1992 • 316 citations

Shigella flexneri enters human colonic Caco-2 epithelial cells through the basolateral pole

1992 • 315 citations

Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis.

1994 • 289 citations

Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells

1995 • 279 citations

Role of M cells in initial antigen uptake and in ulcer formation in the rabbit intestinal loop model of shigellosis

1989 • 272 citations

Apoptosis and Its Role in Human Disease

1994 • 232 citations

IpaB mediates macrophage apoptosis induced by Shigella flexneri

1994 • 228 citations

Listeria monocytogenes induces apoptosis of infected hepatocytes.

1996 • 213 citations

Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation

1995 • 210 citations

Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

1994 • 209 citations

Role of Interleukin‐l in Infectious Diseases

1992 • 178 citations

In vivo apoptosis in Shigella flexneri infections

1996 • 173 citations

OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis

1991 • 172 citations

Bacterial entry into epithelial cells: the paradigm of Shigella

1996 • 159 citations

DNA Fragmentation and Cytolysis in U937 Cells Treated with Diphtheria Toxin or Other Inhibitors of Protein Synthesis

1993 • 150 citations

Apoptosis induced by bacterial pathogens

1994 • 141 citations

Macrophage subpopulations in lamina propria of normal and inflamed colon and terminal ileum.

1989 • 140 citations

Role of interleukin-1 in the pathogenesis of experimental shigellosis.

1995 • 136 citations

ICE/CED-3 proteasesin apoptosis

1996 • 128 citations

Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells

1995 • 120 citations

In situ characterization of inflammatory responses in the rectal mucosae of patients with shigellosis

1997 • 102 citations

Strategies for development of potential candidate Shigella vaccines

1993 • 53 citations

In vivo induction of apoptosis in immature thymocytes by staphylococcal enterotoxin B.

1992 • 48 citations

The localization of macrophage subsets and dendritic cells in the gastrointestinal tract of the mouse with special reference to the presence of high endothelial venules

1990 • 37 citations

Models to study enteropathogenic bacteria: lessons learned from Shigella

1995 • 9 citations