A bacterial invasin induces macrophage apoptosis by binding directly to ICE.

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Shigella flexneri induces apoptosis in infected macrophages

1992 • 1,130 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Involvement of a plasmid in the invasive ability of Shigella flexneri

1982 • 733 citations

Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells

1993 • 722 citations

EPITHELIAL CELL PENETRATION AS AN ESSENTIAL STEP IN THE PATHOGENESIS OF BACILLARY DYSENTERY

1964 • 628 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

1988 • 377 citations

The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD.

1994 • 362 citations

IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.

1992 • 316 citations

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

1995 • 313 citations

Cloning of plasmid DNA sequences involved in invasion of HeLa cells by Shigella flexneri

1985 • 306 citations

Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri

1994 • 298 citations

Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis.

1994 • 289 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells

1995 • 279 citations

The nuclear tyrosine kinase c-abl negatively regulates cell growth

1994 • 277 citations

Role of M cells in initial antigen uptake and in ulcer formation in the rabbit intestinal loop model of shigellosis

1989 • 272 citations

IpaB mediates macrophage apoptosis induced by Shigella flexneri

1994 • 228 citations

Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

1994 • 209 citations

Virulence-associated genetic regions comprising 31 kilobases of the 230-kilobase plasmid in Shigella flexneri 2a

1988 • 195 citations

YopB and YopD constitute a novel class of Yersinia Yop proteins

1993 • 179 citations

The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy.

1995 • 158 citations

Role of interleukin-1 in the pathogenesis of experimental shigellosis.

1995 • 136 citations

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

1992 • 136 citations

Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.

1995 • 133 citations

Morphology of Rectal Mucosa of Patients with Shigellosis

1991 • 129 citations

Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells

1995 • 120 citations

Plasmid-mediated early killing of eucaryotic cells by Shigella flexneri as studied by infection of J774 macrophages

1987 • 104 citations

Rectal Histology in Acute Bacillary Dysentery

1986 • 93 citations

Direct evidence for an intracellular role for tumor necrosis factor-alpha 1. Microinjection of tumor necrosis factor kills target cells.

1990 • 71 citations

Characterization of B-cell epitopes on IpaB, an invasion-associated antigen of Shigella flexneri: identification of an immunodominant domain recognized during natural infection

1993 • 64 citations

Direct evidence for an intracellular role for IFN-gamma. Microinjection of human IFN-gamma induces Ia expression on murine macrophages.

1990 • 48 citations