Regulation of the Oncogenic Activity of BCR-ABL by a Tightly Bound Substrate Protein RIN1

Protein modules and signalling networks

1995 • 2,447 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

1994 • 454 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.

1987 • 380 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

1997 • 350 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

Src family protein tyrosine kinases and cellular signal transduction pathways

1995 • 298 citations

The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

1996 • 293 citations

Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia.

1994 • 293 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene.

1995 • 268 citations

Control of hemopoiesis by a bone marrow stromal cell clone: lipopolysaccharide- and interleukin-1-inducible production of colony- stimulating factors

1987 • 263 citations

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1995 • 261 citations

Proline-rich sequences that bind to Src homology 3 domains with individual specificities.

1995 • 257 citations

Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.

1994 • 256 citations

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1996 • 235 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

1996 • 196 citations

Differential Complementation of Bcr-Abl Point Mutants with c-Myc

1994 • 194 citations

SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl

1994 • 189 citations

The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.

1989 • 180 citations

Receptor tyrosine kinases and their targets

1994 • 177 citations

Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling

1991 • 175 citations

A Human Protein Selected for Interference with Ras Function Interacts Directly with Ras and Competes with Raf1

1995 • 170 citations

Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.

1994 • 161 citations

Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice.

1993 • 158 citations

the Viral and Cellular Forms of the Abelson (Dbl) Oncogene

1988 • 157 citations

Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells

1993 • 150 citations

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.

1991 • 149 citations

Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells.

1989 • 145 citations

Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway.

1994 • 136 citations

Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells

1993 • 127 citations

Cellular interactions of CRKL, and SH2-SH3 adaptor protein.

1994 • 116 citations

SH1 Domain Autophosphorylation of P210 BCR/ABL Is Required for Transformation but Not Growth Factor Independence

1993 • 116 citations

Grap Is a Novel SH3-SH2-SH3 Adaptor Protein That Couples Tyrosine Kinases to the Ras Pathway

1996 • 114 citations

Protein binding and signaling properties of RIN1 suggest a unique effector function

1997 • 114 citations

Rescue of defective mitogenic signaling by D-type cyclins.

1995 • 111 citations

Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene.

1991 • 89 citations

Abl tyrosine protein kinase

1995 • 81 citations

Signaling by ABL oncogenes through cyclin D1.

1995 • 78 citations

SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.

1993 • 77 citations

A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia.

1990 • 52 citations

v-abl causes hematopoietic disease distinct from that caused by bcr-abl.

1991 • 46 citations

Structural characterization of the BCR gene product.

1989 • 33 citations